scholarly journals BARTONELLA BODIES IN THE BLOOD OF A NON-SPLENECTOMIZED DOG

1935 ◽  
Vol 62 (3) ◽  
pp. 353-258 ◽  
Author(s):  
James B. McNaught ◽  
Francis M. Woods ◽  
Virgil Scott
Keyword(s):  
Intravenous Injection ◽  
Plasma Protein ◽  
Whole Blood ◽  
Protein Level ◽  
Plasma Proteins ◽  
Basal Diet ◽  
Blood Stream ◽  
Inhibitory Effect ◽  
The Many ◽  
Plasma Protein Level

A non-splenectomized dog, on a vitamin-adequate basal diet, in the course of a plasmapheresis experiment, developed an uncontrollable anemia associated with the presence of bodies in or on the erythrocytes, indistinguishable from the descriptions of Bartonella canis. The normal plasma protein level of 7.3 per cent was reduced to 4.1 per cent by diet and the removal of 5354 ml. of whole blood in 33 bleedings. The Bartonella infection was transferred to a splenectomized dog by an intravenous injection of whole blood. Each animal was apparently sterilized by one injection of neoarsphenamine equivalent to 15 mg. per kilo weight. It is possible that the spleen liberates some substance into the blood stream which has an inhibitory effect upon a latent Bartonella infection and that this protective substance was diminished by the many bleedings associated with the lowering of plasma proteins in the non-splenectomized dog and was lacking in the inoculated splenectomized dog.

scholarly journals CASEIN DIGESTS PARENTERALLY UTILIZED TO FORM BLOOD PLASMA PROTEIN

1941 ◽  
Vol 73 (6) ◽  
pp. 727-743 ◽  
Author(s):  
S. C. Madden ◽  
L. J. Zeldis ◽  
A. D. Hengerer ◽  
L. L. Miller ◽  
A. P. Rowe ◽  
...  
Keyword(s):  
Blood Plasma ◽  
Plasma Protein ◽  
Plasma Proteins ◽  
Protein Production ◽  
Basal Diet ◽  
Clinically Normal ◽  
Blood Plasma Proteins ◽  
Resistance To Infection ◽  
Protein Output ◽  
Uniform Plasma

When blood plasma proteins are depleted by bleeding with return of the washed red cells (plasmapheresis) it is possible to bring dogs to a steady state of hypoproteinemia and a uniform plasma protein production on a basal diet limited in protein. Such dogs are clinically normal but have a lowered resistance to infection and certain intoxications. Casein digests given by vein or subcutaneously to such plasma depleted dogs are effective in promoting abundant new plasma protein production. Casein digest L by vein is equivalent to whole liver of like protein equivalence by mouth. The ratio of new plasma protein production to protein intake is 20 to 25 per cent in both instances. Casein digest L by vein gives the same response in plasma protein output as the same digest by mouth. Protein digest X by vein requires addition of tryptophane and cysteine to be effective in plasma protein production. The added cysteine sulfur is more than 95 per cent retained by the dog. The speed of digest injection has no effect on its utilization, within the range tested. Casein digest L given by vein to non-depleted dogs is less well utilized than in dogs depleted of plasma protein.

scholarly journals BLOOD PLASMA PROTEIN REGENERATION CONTROLLED BY DIET

1935 ◽  
Vol 61 (2) ◽  
pp. 261-282 ◽  
Author(s):  
W. T. Pommerenke ◽  
H. B. Slavin ◽  
D. H. Kariher ◽  
G. H. Whipple
Keyword(s):  
Blood Plasma ◽  
Plasma Protein ◽  
Plasma Proteins ◽  
Protein Production ◽  
Protein A ◽  
Basal Diet ◽  
Food Protein ◽  
Potency Ratio ◽  
Health And Disease ◽  
Clinical Conditions

When blood plasma proteins are depleted by bleeding, with return of washed red cells (plasmapheresis) it is possible to bring the dog to a steady state of low plasma protein and uniform plasma protein production on a basal diet. Such dogs are excellent test subjects by which the potency of various diet factors for plasma protein regeneration can be measured. To regenerate plasma proteins in any significant amount the depleted dog requires food protein. Some proteins are very potent for new plasma protein production and others are utilized poorly. Beef serum is very potent and its proteins (2.6 gm.) will produce 1 gm. of new plasma protein in the depleted dog—a potency ratio of 2.6. Kidney protein stands at the bottom of our list and the dog needs 21 gm. of kidney protein to regenerate 1 gm. of plasma protein—a potency ratio of 21.0. Some grain proteins approximate the potency of beef serum and may show potency ratios of 2.7 to 4.6. Some of these grain proteins appear to favor the production of globulin more than albumin in the plasma. Skeletal muscle, gizzard (smooth muscle), lactalbumin and egg white fall into a favorable group with a potency ratio of 5.3 to 6.0. Whole liver, liver fractions, casein, and beef heart are a little less potent and present potency ratios of 6.5 to 8.0. Many of these food substances favor the production of albumin more than globulin. Pancreas and salmon muscle show less favorable potency ratios of 19.0 and 15.0 respectively. Fasting periods indicate that these depleted dogs can produce little if any new plasma protein. Iron feeding in some unexplained manner will influence body metabolism so that an excess of plasma protein will be produced. These observations have a bearing on clinical conditions associated with hypoproteinemia and give suggestions for diet aid or control in some of these abnormal states. The make-up of the diet is obviously of great interest and it is possible that protein combinations may be more potent than a single protein or that food potency ratios may differ in health and disease.

scholarly journals Failure of Plasma Protein Level to Indicate Developing Fatty Liver in Chickens

1968 ◽  
Vol 47 (4) ◽  
pp. 1098-1100 ◽  
Author(s):  
M.J. Duke ◽  
R.K. Ringer ◽  
J.H. Wolford
Keyword(s):  
Fatty Liver ◽  
Plasma Protein ◽  
Protein Level ◽  
Plasma Protein Level

scholarly journals PLASMA PROTEIN METABOLISM—NORMAL AND ASSOCIATED WITH SHOCK

1944 ◽  
Vol 80 (6) ◽  
pp. 455-475 ◽  
Author(s):  
R. M. Fink ◽  
T. Enns ◽  
C. P. Kimball ◽  
H. E. Silberstein ◽  
W. F. Bale ◽  
...  
Keyword(s):  
Plasma Protein ◽  
Protein Metabolism ◽  
Plasma Proteins ◽  
Blood Stream ◽  
Dilution Curve ◽  
Body Protein ◽  
Protein Mass ◽  
Rapid Exchange ◽  
Isotope Concentration ◽  
Heavy Nitrogen

Labeled plasma proteins are produced by administering to dogs the amino acid lysine synthesized with heavy nitrogen. Such labeled proteins are apparently indistinguishable biologically from proteins of normal isotope concentration. Labeled plasma proteins, as plasma, injected into normal dogs pass out of the blood stream at an initially rapid but constantly decreasing non-logarithmic rate. This outflow is balanced by a simultaneous inflow of plasma proteins from the tissues. Fifty per cent of the labeled protein is out of the blood stream in about 24 hours; 75 per cent in about 6 days. Shock due to trauma of intestine or leg shows a dilution curve of labeled plasma protein not unlike that of the normal dog. If anything, dilution appears a little less rapid in shock. Since the usual shrinkage of plasma volume and plasma protein mass is present in these shocked dogs, these data are compatible with a decreased inflow of protein into the plasma during shock. Methods are described which are suitable for the use of heavy nitrogen incorporated in the epsilon group of lysine and its subsequent analysis in body fluids. These data may indicate that the plasma proteins are normally in constant and rapid exchange with a mobile pool of body protein.

Total plasma protein level as an indicator of condition in wild American kestrels (Falco sparverius)

1997 ◽  
Vol 75 (5) ◽  
pp. 680-686 ◽  
Author(s):  
Russell D. Dawson ◽  
Gary R. Bortolotti
Keyword(s):  
Plasma Protein ◽  
Protein Level ◽  
Egg Laying ◽  
Falco Sparverius ◽  
Total Plasma ◽  
Protein Levels ◽  
American Kestrels ◽  
Total Plasma Protein ◽  
In The Wild ◽  
Plasma Protein Level

Total plasma protein levels were determined for 292 female and 228 male American kestrels (Falco sparverius) in the wild. Plasma protein levels were significantly higher in females than in males, and higher during prelaying than during incubation. For both sexes, plasma protein levels did not vary significantly with the number of days before or after egg laying on which the sample was taken, time of sampling, prey abundance, age, molt, or infection by the blood parasite Haemoproteus sp. Protein levels in females increased with date of sampling and body condition during prelaying, while the same pattern was seen in males during incubation. With the exception of those of prelaying females, plasma protein levels increased with ambient temperature. The results of this study suggest that at least some of the variation observed in total protein levels is attributable to physical condition. However, further investigation is required before the reliability of using total plasma protein level as a tool to assess the health and condition of kestrels is known.

OBSERVATIONS ON PLASMA-PROTEINS AND IT'S RELATIONSHIP WITH THE BODY WEIGHT AT PMCH, PATNA

2021 ◽  
pp. 26-28
Author(s):  
Nutan Kumari ◽  
Vibha Rani ◽  
[Prof.] Rajiva Kumar Singh ◽  
Debarshi Jana
Keyword(s):  
Body Weight ◽  
Plasma Protein ◽  
Healthy Subjects ◽  
Plasma Proteins ◽  
The Body ◽  
The Other ◽  
Reference Level ◽  
Study Group ◽  
Medical College ◽  
Plasma Protein Level

Background : The human body is composed of ve substances namely water, protein, fat, carbohydrate and minerals. All these substances are very closely interrelated, each acting with the other. Among these water acts as a bridge. The subjects included were medical students, staff of Methods : Patna Medical College, Patna, Bihar, businessman, serviceman and housewives. Results : The present study has been made on plasma protein in 54 normal healthy subjects of both sexes, 27 subjects of vegetarian group and 27 subjects of non-vegetarian group. In the whole study group the level of mean plasma protein ranged from 5.8 g/dL – 8.4 g/dL with a mean of 6.96 g/dL. (S.D. - 0.50, S.E. - 0.06). The plasma protein level Conclusion : in the study group is almost identical with the standard reference level.

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