scholarly journals PLASMA PROTEIN METABOLISM—ELECTROPHORETIC STUDIES

1945 ◽  
Vol 82 (6) ◽  
pp. 411-430 ◽  
Author(s):  
L. J. Zeldis ◽  
E. L. Alling ◽  
A. B. McCoord ◽  
J. P. Kulka
Keyword(s):  
Human Plasma ◽  
Protein Metabolism ◽  
Gamma Globulin ◽  
Plasma Lipids ◽  
Plasma Lipid ◽  
Elevated Plasma ◽  
Lipid Levels ◽  
Electrophoretic Patterns ◽  
Dog Plasma ◽  
Beta Globulin

Electrophoretic patterns of human and dog plasma are markedly altered by the extraction of a large part of the plasma lipids. Total electrophoretic areas, relative areas of individual electrophoretic components, and electrophoretic albumin: globulin ratios undergo change. For human plasma, such extractions confirm previous observations that a particularly rich lipid content characterizes beta globulin. Abnormally large beta peaks regularly occur in the presence of elevated plasma lipids. Marked increases in gamma globulin, however, are also found to be due in large part to elevated plasma lipid levels in certain abnormal human plasmas. The greatest relative amount of lipid in dog plasma, in contrast to human plasma, is associated not with the beta globulin, but with components usually designated as alpha globulins. Not only the areas, but the configuration and the number of alpha globulin peaks in dog plasma are altered by the extraction of plasma lipids. The results demonstrate that increased alpha globulin areas which occur in the plasma of hypoproteinemic dogs are due in large part to elevated plasma lipid levels.

Abstract P555: Plasma Lipids And The Risk For Stroke In The Reasons For Geographic And Racial Differences In Stroke Study (regards).

Circulation ◽  
2020 ◽  
Vol 141 (Suppl_1) ◽  
Author(s):  
Neil Zakai ◽  
Jessica Minnier ◽  
Monika M Safford ◽  
Lisandro Colantonio ◽  
Marguerite M Irvin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Racial Differences ◽  
Stroke Risk ◽  
Plasma Lipids ◽  
Cox Regression ◽  
Strong Association ◽  
Plasma Lipid ◽  
Lipid Levels ◽  
Cvd Risk ◽  
Stroke Incidence

Introduction: Whether plasma lipid levels are associated with stroke risk remains controversial, with even less data for American blacks versus whites. Hypothesis: We hypothesized that abnormal lipid levels are not associated with stroke incidence in either blacks or whites. Methods: The REasons for Geographic And Racial Differences in Stroke (REGARDS) study recruited 30,283 black and white individuals aged 45+ from the contiguous U.S. between 2003 to 2007, participants with a history of stroke at baseline were excluded. Participants were followed until 2018 for stroke events following the WHO definition and confirmed by review of medical records. The association of lipid measures with stroke were assessed using Cox regression models adjusted for traditional CVD risk factors and an age-x-race interaction term. Results: With 27,714 participants (mean age 64.85± 9.43, 59.5% white and 55.4% female), over a median of 11 years of follow up, 1,415 stroke events occurred, of which 599 among blacks. After adjusting for traditional stroke risk factors, there were modest associations between higher total cholesterol and higher LDL, but not higher triglycerides, with stroke risk. There was no evidence of a race interaction. Overall, HDL levels were not associated with stroke risk. However, when stratified by race, whites had a reduced risk of stroke with higher HDL-C, whereas no association was seen among blacks (p-interaction 0.09). Conclusion: In REGARDs, there was a modest association of cholesterol measures with stroke risk. The association for HDL with stroke may be influenced by race, with a less strong association among blacks than among whites.

The in Vitro Anticoagulant Activity of Human Plasma Lipids

1965 ◽  
Vol 13 (02) ◽  
pp. 531-542
Author(s):  
J Cohen ◽  
C. F Reed ◽  
S. B Troup
Keyword(s):  
Human Plasma ◽  
Inhibitory Activity ◽  
Plasma Lipids ◽  
Present Report ◽  
Anticoagulant Activity ◽  
Lipid Fraction ◽  
Plasma Lipid ◽  
Lipid Mixture ◽  
Platelet Poor Plasma

SummaryThe present report describes the in vitro inhibition of prothrombin consumption by lipid extracted from normal human platelet-poor plasma. Pro-coagulant lipids and the test plasma lipids were dissolved in the same solvent and evaporated to dryness. The dried lipid mixture was emulsified in platelet-poor plasma, and the plasma clotted by recalcification. Inhibition of prothrombin consumption by plasma lipid was observed when the ratio of plasma lipid to procoagulant lipid equaled or exceeded 5:1. The inhibitory effect of plasma lipid on prothrombin consumption was not observed when procoagulant activity was provided by intact platelets or platelet granules.Human plasma lipids have been fractionated on silicic acid columns to permit identification of the plasma lipid component responsible for the inhibition of prothrombin consumption. The inhibitory activity is present in a lipid fraction which is 95% lecithin. Other plasma lipid components exhibit little or no inhibitory activity.

scholarly journals Integrative genomic analysis identified common regulatory networks underlying the correlation between coronary artery disease and plasma lipid levels

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Liuying Chen ◽  
Yinghao Yao ◽  
Chaolun Jin ◽  
Shen Wu ◽  
Qiang Liu ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Regulatory Networks ◽  
Molecular Mechanisms ◽  
Plasma Lipids ◽  
Lipid Level ◽  
Plasma Lipid ◽  
Lipid Levels ◽  
Regulatory Relationship ◽  
Artery Disease

Abstract Background Coronary artery disease (CAD) and plasma lipid levels are highly correlated, indicating the presence of common pathways between them. Nevertheless, the molecular pathways underlying the pathogenic comorbidities for both traits remain poorly studied. We sought to identify common pathways and key driver genes by performing a comprehensive integrative analysis based on multi-omic datasets. Methods By performing a pathway-based analysis of GWAS summary data, we identified that lipoprotein metabolism process-related pathways were significantly associated with CAD risk. Based on LD score regression analysis of CAD-related SNPs, significant heritability enrichments were observed in the cardiovascular and digestive system, as well as in liver and gastrointestinal tissues, which are the main regulators for lipid level. Results We found there existed significant genetic correlation between CAD and other lipid metabolism related traits (the smallest P value < 1 × 10− 16). A total of 13 genes (e.g., LPA, APOC1, APOE and SLC22A3) was found to be overlapped between CAD and plasma lipid levels. By using the data-driven approach that integrated transcriptome information, we discovered co-expression modules associated prominently with both CAD and plasma lipids. With the detailed topology information on gene-gene regulatory relationship, we illustrated that the identified hub genes played important roles in the pathogenesis of CAD and plasma lipid turbulence. Conclusion Together, we identified the shared molecular mechanisms underlying the correlation between CAD and plasma lipid levels.

scholarly journals Macrophages are associated with lipid-rich carotid artery plaques, echolucency on B-mode imaging, and elevated plasma lipid levels

2002 ◽  
Vol 35 (1) ◽  
pp. 137-145 ◽  
Author(s):  
Marie-Louise M. Grønholdt ◽  
Børge G. Nordestgaard ◽  
Jacob Bentzon ◽  
Britt M. Wiebe ◽  
Ji Zhou ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Plasma Lipid ◽  
Elevated Plasma ◽  
Lipid Levels

scholarly journals Macrophages are associated with lipid-rich carotid artery plaques, echolucency on B-mode imaging, and elevated plasma lipid levels*1

2002 ◽  
Vol 35 (1) ◽  
pp. 137-145 ◽  
Author(s):  
M GRONHOLDT ◽  
B NORDESTGAARD ◽  
J BENTZON ◽  
B WIEBE ◽  
J ZHOU ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Plasma Lipid ◽  
Elevated Plasma ◽  
Lipid Levels

scholarly journals PLASMA PROTEIN METABOLISM—ELECTROPHORETIC STUDIES

1945 ◽  
Vol 81 (5) ◽  
pp. 515-537 ◽  
Author(s):  
L. J. Zeldis ◽  
E. L. Alling
Keyword(s):  
Plasma Protein ◽  
Plasma Proteins ◽  
Blood Stream ◽  
Human Albumin ◽  
Electrophoretic Patterns ◽  
Dog Plasma ◽  
Beta Globulin ◽  
Veronal Buffer ◽  
Protein Components ◽  
High Beta

Electrophoretic patterns of normal dog plasma in veronal buffer at pH 8.5 are shown to be essentially similar to patterns of human plasma. Dog albumin has a higher mobility than human albumin and in a mixture of dog and human plasmas migrates as a partially separated peak. Normal dog plasma frequently shows four alpha globulin peaks. Rates of restoration of plasma protein components in dogs subjected to acute plasmapheresis have been studied by electrophoresis. During the first 24 hours following such acute depletion, appreciable quantities of all electrophoretic components of the plasma proteins enter the circulating blood stream even when food is not given and has not been given for 12 hours before plasmapheresis. In such fasting periods albumin and total globulin appear in approximately the proportions present in normal plasma. Alpha and beta globulins continue relatively elevated during subsequent days in which caloric and protein intakes are adequate for weight and nitrogen gains. Initial albumin levels, however, are regained more slowly than those of total globulin. The relative proportions of the electrophoretic components of plasma proteins may be disturbed from normal following a single acute depletion for as long as 2 to 3 weeks after the total protein level has returned to normal. Abnormally high beta globulin and fibrinogen, but a low albumin, were found in a dog with an acute and chronic cholangitis and hepatitis. Similar elevation of gamma globulin was noted in a dog in which a hemolytic reaction occurred.

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