scholarly journals Immunophenotypic Markers and Antiretroviral Therapy (IMART): T Cell Activation and Maturation Help Predict Treatment Response

2004 ◽  
Vol 189 (10) ◽  
pp. 1811-1820 ◽  
Author(s):  
Donna Mildvan ◽  
Ronald J. Bosch ◽  
Ryung S. Kim ◽  
John Spritzler ◽  
David W. Haas ◽  
...  
Keyword(s):  
T Cell ◽  
Antiretroviral Therapy ◽  
Treatment Response ◽  
T Cell Activation ◽  
Cell Activation ◽  
Predict Treatment Response

scholarly journals Maintenance of Viral Suppression in Human Immunodeficiency Virus Controllers Despite Waning T-Cell Responses During Antiretroviral Therapy

2020 ◽  
Vol 222 (11) ◽  
pp. 1837-1842 ◽  
Author(s):  
Nikolaus Jilg ◽  
Pilar Garcia-Broncano ◽  
Michael Peluso ◽  
Florencia P Segal ◽  
Ronald J Bosch ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cell ◽  
Antiretroviral Therapy ◽  
T Cell Activation ◽  
Cell Activation ◽  
T Cell Responses ◽  
Cell Responses ◽  
Immunodeficiency Virus ◽  
Undetectable Viremia ◽  
Hiv Controllers

Abstract AIDS Clinical Trials Group study A5308 found reduced T-cell activation and exhaustion in human immunodeficiency virus (HIV) controllers start antiretroviral therapy (ART). We further assessed HIV-specific T-cell responses and post-ART viral loads. Before ART, the 31% of participants with persistently undetectable viremia had more robust HIV-specific T-cell responses. During ART, significant decreases were observed in a broad range of T-cell responses. Eight controllers in A5308 and the Study of the Consequences of the Protease Inhibitor Era (SCOPE) cohort showed no viremia above the level of quantification in the first 12 weeks after ART discontinuation. ART significantly reduced HIV-specific T-cell responses in HIV controllers but did not adversely affect controller status after ART discontinuation.

scholarly journals Changes in Inflammation but Not in T-Cell Activation Precede Non-AIDS-Defining Events in a Case-Control Study of Patients on Long-term Antiretroviral Therapy

2017 ◽  
Vol 218 (2) ◽  
pp. 239-248 ◽  
Author(s):  
Konstantia Angelidou ◽  
Peter W Hunt ◽  
Alan L Landay ◽  
Cara C Wilson ◽  
Benigno Rodriguez ◽  
...  
Keyword(s):  
T Cell ◽  
Antiretroviral Therapy ◽  
T Cell Activation ◽  
Cell Activation ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

Low CD4+ T-cell counts in HIV patients receiving effective antiretroviral therapy are associated with CD4+ T-cell activation and senescence but not with lower effector memory T-cell function

2006 ◽  
Vol 120 (2) ◽  
pp. 163-170 ◽  
Author(s):  
Sonia Fernandez ◽  
Patricia Price ◽  
Elizabeth J. McKinnon ◽  
Richard C. Nolan ◽  
Martyn A. French
Keyword(s):  
T Cell ◽  
Antiretroviral Therapy ◽  
T Cell Activation ◽  
Cell Activation ◽  
Cell Function ◽  
Cd4 T Cell ◽  
Effector Memory ◽  
Hiv Patients ◽  
Memory T Cell ◽  
Cell Counts

scholarly journals Factors Associated With CD8+ T-Cell Activation in HIV-1–Infected Patients on Long-term Antiretroviral Therapy

2014 ◽  
Vol 67 (2) ◽  
pp. 153-160 ◽  
Author(s):  
Lu Zheng ◽  
Babafemi Taiwo ◽  
Rajesh T. Gandhi ◽  
Peter W. Hunt ◽  
Ann C. Collier ◽  
...  
Keyword(s):  
T Cell ◽  
Antiretroviral Therapy ◽  
T Cell Activation ◽  
Cell Activation ◽  
Cd8 T Cell ◽  
Factors Associated ◽  
Hiv 1

scholarly journals The impact of age on the prognostic capacity of CD8+ T-cell activation during suppressive antiretroviral therapy

AIDS ◽  
2013 ◽  
Vol 27 (13) ◽  
pp. 2101-2110 ◽  
Author(s):  
Judith J. Lok ◽  
Peter W. Hunt ◽  
Ann C. Collier ◽  
Constance A. Benson ◽  
Mallory D. Witt ◽  
...  
Keyword(s):  
T Cell ◽  
Antiretroviral Therapy ◽  
T Cell Activation ◽  
Cell Activation ◽  
Cd8 T Cell ◽  
The Impact

CD8 T-Cell Activation Is Associated With Lipodystrophy and Visceral Fat Accumulation in Antiretroviral Therapy–Treated Virologically Suppressed HIV-Infected Patients

2013 ◽  
Vol 64 (4) ◽  
pp. 360-366 ◽  
Author(s):  
Giovanni Guaraldi ◽  
Kety Luzi ◽  
Giusi Maria Bellistrì ◽  
Stefano Zona ◽  
Ana Rita Domingues da Silva ◽  
...  
Keyword(s):  
T Cell ◽  
Antiretroviral Therapy ◽  
T Cell Activation ◽  
Visceral Fat ◽  
Cell Activation ◽  
Cd8 T Cell ◽  
Fat Accumulation ◽  
Visceral Fat Accumulation

scholarly journals Residual T cell activation and skewed CD8+ T cell memory differentiation despite antiretroviral therapy-induced HIV suppression

2018 ◽  
Vol 195 ◽  
pp. 127-138 ◽  
Author(s):  
Ramla F. Tanko ◽  
Andreia P. Soares ◽  
Lindi Masson ◽  
Nigel J. Garrett ◽  
Natasha Samsunder ◽  
...  
Keyword(s):  
T Cell ◽  
Antiretroviral Therapy ◽  
T Cell Activation ◽  
Cell Activation ◽  
Cd8 T Cell ◽  
T Cell Memory ◽  
Cell Memory ◽  
Memory Differentiation ◽  
Cd8 T Cell Memory

scholarly journals Antiretroviral Therapy Initiated During Acute HIV Infection Fails to Prevent Persistent T-Cell Activation

2013 ◽  
Vol 62 (5) ◽  
pp. 505-508 ◽  
Author(s):  
Michael J. Vinikoor ◽  
Anna Cope ◽  
Cynthia L. Gay ◽  
Guido Ferrari ◽  
Kara S. McGee ◽  
...  
Keyword(s):  
T Cell ◽  
Antiretroviral Therapy ◽  
Hiv Infection ◽  
T Cell Activation ◽  
Cell Activation ◽  
Acute Hiv Infection ◽  
Acute Hiv

scholarly journals Down‐Regulation of Interleukin‐7 Receptor (CD127) in HIV Infection Is Associated with T Cell Activation and Is a Main Factor Influencing Restoration of CD4+Cells after Antiretroviral Therapy

2008 ◽  
Vol 198 (10) ◽  
pp. 1466-1473 ◽  
Author(s):  
José M. Benito ◽  
Mariola López ◽  
Sara Lozano ◽  
Juan González‐Lahoz ◽  
Vincent Soriano
Keyword(s):  
T Cell ◽  
Antiretroviral Therapy ◽  
Hiv Infection ◽  
T Cell Activation ◽  
Cell Activation ◽  
Cd4 Cells ◽  
Down Regulation ◽  
Interleukin 7 ◽  
Main Factor

Early antiretroviral therapy with raltegravir generates sustained reductions in HIV reservoirs but not lower T-cell activation levels

AIDS ◽  
2015 ◽  
Vol 29 (8) ◽  
pp. 911-919 ◽  
Author(s):  
William J. Hey-Cunningham ◽  
John M. Murray ◽  
Ven Natarajan ◽  
Janaki Amin ◽  
Cecilia L. Moore ◽  
...  
Keyword(s):  
T Cell ◽  
Antiretroviral Therapy ◽  
T Cell Activation ◽  
Cell Activation ◽  
Hiv Reservoirs
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