scholarly journals Risk Factors for Acquisition of Clostridium difficile–Associated Diarrhea among Outpatients at a Cancer Hospital

2005 ◽  
Vol 26 (8) ◽  
pp. 680-684 ◽  
Author(s):  
Tara N. Palmore ◽  
SeJean Sohn ◽  
Sharp F. Malak ◽  
Janet Eagan ◽  
Kent A Sepkowitz
Keyword(s):  
Risk Factors ◽  
Clostridium Difficile ◽  
Case Control Study ◽  
Tertiary Care ◽  
Antibiotic Use ◽  
Generation Cephalosporin ◽  
Case Control ◽  
Cancer Center ◽  
Care Hospital ◽  
Control Study

AbstractBackground:Clostridium difficile-associated diarrhea (CDAD) is an important infection in hospital settings. Its impact on outpatient care has not been well defined.Objective:To examine risk factors of ambulatory cancer patients with CDAD.Design:Case-control study.Setting:Memorial Sloan-Kettering Cancer Center, a tertiary-care hospital.Methods:Cases of CDAD among oncology outpatients from January 1999 through December 2000 were identified via positive C. difficile toxin assay results on stool specimens sent from clinics or the emergency department. A 1:3 matched case-control study examined exposures associated with CDAD.Results:Forty-eight episodes of CDAD were identified in cancer outpatients. The mean age was 51 years; 44% were female. Forty-one (85%) had received antibiotics within 60 days of diagnosis, completing courses a median of 16.5 days prior to diagnosis. Case-patients received longer courses of first-generation cephalosporins (4.8 vs 3.2 days; P = .03) and fluoroquinolones (23.6 vs 8 days; P < .01) than did control-patients. Those receiving clindamycin were 3.9-fold more likely to develop CDAD (P < .01). For each additional day of clindamycin or third-generation cephalosporin exposure, patients were 1.29- and 1.26-fold more likely to develop CDAD (P < .01 and .04, respectively). The 38 CDAD patients hospitalized during the risk period (79.2%) spent more time as inpatients than did control-patients (19.3 vs 9.7 days; P <. 001).Conclusions:Antibiotic use, especially with cephalosporins and clindamycin, and prolonged hospitalization contributed to the development of CDAD. Outpatient CDAD appears to be most strongly related to inpatient exposures; reasons for the delayed development of symptoms are unknown.

Risk Factors forClostridium difficileInfection in a Hepatology Ward

2007 ◽  
Vol 28 (2) ◽  
pp. 202-204 ◽  
Author(s):  
Dominique Vanjak ◽  
Guillaume Girault ◽  
Catherine Branger ◽  
Pierre Rufat ◽  
Dominique-Charles Valla ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Clostridium Difficile ◽  
Autoimmune Hepatitis ◽  
Attack Rate ◽  
Case Control Study ◽  
Antibiotic Use ◽  
Case Control ◽  
Strain Typing ◽  
Control Study

During 2001,Clostridium difficileinfection was observed in 23 patients hospitalized in a hepatology ward (attack rate, 0.9%). Since strain typing ruled out a clonal dissemination, we performed a case-control study. In addition to antibiotic use as a risk factor, theC. difficileinfection rate was higher among patients with autoimmune hepatitis (P< .01).

scholarly journals Risk factors associated with carcinoma breast: a case control study

2017 ◽  
Vol 4 (9) ◽  
pp. 3136 ◽  
Author(s):  
Palachandra A. ◽  
Ishwaraprasad G. D. ◽  
Sreelatha C. Y. ◽  
Sumana M.
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Case Control Study ◽  
Tertiary Care ◽  
Reproductive Factors ◽  
Developed Countries ◽  
Case Control ◽  
Age At Menarche ◽  
Care Hospital ◽  
Control Study

Background: The burden of breast cancer is increasing in both developed and developing countries; the peak occurrence of breast cancer in developed countries is above the age of 50 whereas in India it is above the age of 40. Reproductive factors contribute most to the development of breast cancer. Nulliparity, more age at first live birth and no breastfeeding are major reproductive risk factors for breast cancer in the developed countries. The role of reproductive factors in the development of breast cancer in Indian population is different as compared with that seen in the western population. Objective of this study was to find out some of the various risk factors of breast cancer among patients attending the tertiary care hospital in Hassan.Methods: The case control study was conducted at surgery wards of Sri Chamarajendra district hospital which is a teaching hospital. The calculated number of cases was 110, including 110 controls total 220 individuals were included in the study. A case was defined as any female patient histopathologically confirmed to have breast cancer.Results: The maximum cases (38%) were between 51 to 60 years of age group. Age at menarche, age at first child birth, age at marriage and age at menopause reported significant risk for breast cancer.Conclusions: Information, education and communication activities regarding these risk factors, early signs and symptoms of breast carcinoma, and breast self‑examination should be imparted to the women to create awareness about this fatal disease.

scholarly journals A case control study on behavioural risk factors of anaemia among pregnant women delivered at a tertiary care hospital in Haryana

2021 ◽  
Vol 10 (8) ◽  
pp. 3062
Author(s):  
Sunny Ohlan ◽  
S. K. Jha ◽  
Parul Singhal
Keyword(s):  
Risk Factors ◽  
Pregnant Women ◽  
Case Control Study ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Case Control ◽  
Behavioral Risk Factors ◽  
Behavioral Risk ◽  
Care Hospital ◽  
Control Study

Background: Anaemia in pregnancy (AIP) is one of the most common preventable causes of maternal morbidity and poor prenatal outcome. World Health Organization (WHO) has accepted up to 11 gm/dl as the normal hemoglobin (Hb) level in pregnancy. In Haryana state, the prevalence of anaemia among pregnant women is 50.2% in urban areas and 58.1% in rural areas. Pregnant women are predominantly susceptible to nutritional deficiencies because of the increased metabolic demands imposed by pregnancy and its related factors. The aim and objective of the study was to determine the behavioural factors associated with anaemia among pregnant women delivering at a tertiary care hospital in Haryana.Methods: This hospital-based case control study was carried out in BPS Government Medical College for Women, Khanpur Kalan, Sonipat (Haryana). Study was conducted for one year. One hundred sixty-eight pregnant women were enrolled for study. Inclusion criteria for cases and controls was age of 18 years and above and residents of Sonepat district. Analysis was performed by using R statistical software.Results: The majority 57 (67.9%) of cases and 49 (58.3%) of controls were in age group of 18-24 years. Among different behavioral risk factors studied, not using bed nets, not wearing shoes consistently, eating pica and no use of the other drugs during pregnancy were significantly associated with anemia during pregnancy. However, on Multivariable Logistic regression analysis, the major behavioral risk factors for anemia were not using bed net during pregnancy (AOR: 1.83, 95% CI: 0.68-5.01), and not wearing shoes consistently during pregnancy (AOR: 2.77, 95% CI: 0.83-10.01). The odds of getting anaemia in pregnant mothers who reported pica during their pregnancy was AOR = 2.85 (CI: 0.90 – 10.01) than odds of mothers who did not report pica during their pregnancy.Conclusions: Consistent use of bed net, wearing shoes and not consuming pica prevent anaemia during pregnancy. 

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