Factors Influencing Time to Sputum Conversion Among Patients with Smear‐Positive Pulmonary Tuberculosis

Background. Sputum smear-positive pulmonary tuberculosis patients expel infectious viable bacilli for a period following the commencement of treatment. Objective. To determine the time to sputum smear conversion and study the factors influencing it. Design. A prospective study was undertaken at our hospital in Rabat over a six-month period on a cohort of 119 sputum smear positive patients. Patients were followed up fortnightly. At each followup, specimens were collected and processed for microscopy using standard protocol. Results. 96.6% of our patients completed the study (4 deaths). Sputum conversion rate was 42% after two weeks, 73% after one month, and 95% after two months. Univariate and stepwise regression analysis showed that patients who had high smear grading, miliary, and bilateral radiologic lesions were more likely to undergo delayed sputum conversion (P<0.05). Other factors were thought to influence sputum conversion but were not statistically proven in our study. Conclusion. Since viable bacilli continue to be expelled for up to two months, infection control measures should be maintained for such a time. Patients with high smear grading, miliary, and bilateral radiologic lesions need to be monitored more closely.

Download Full-text

Factors Influencing Time to Sputum Conversion Among Patients with Smear‐Positive Pulmonary Tuberculosis

Clinical Infectious Diseases ◽

10.1086/517133 ◽

1998 ◽

Vol 26 (3) ◽

pp. 775-776 ◽

Cited By ~ 5

Author(s):

Edward E. Telzak ◽

Barkat A. Fazal ◽

Glenn S. Turett ◽

Jessica E. Justman ◽

Steve Blum

Keyword(s):

Pulmonary Tuberculosis ◽

Factors Influencing ◽

Smear Positive Pulmonary Tuberculosis ◽

Sputum Conversion

Download Full-text

Factors Influencing Time to Sputum Conversion Among Patients with Smear‐Positive Pulmonary Tuberculosis

Clinical Infectious Diseases ◽

10.1086/517134 ◽

1998 ◽

Vol 26 (3) ◽

pp. 776-776

Author(s):

Michael D. Iseman

Keyword(s):

Pulmonary Tuberculosis ◽

Factors Influencing ◽

Smear Positive Pulmonary Tuberculosis ◽

Sputum Conversion

Download Full-text

COMPARISON THE DURATION OF SPUTUM CONVERSION IN NEW CASE SMEAR POSITIVE PULMONARY TUBERCULOSIS PATIENTS WITH AND WITHOUT DIABETES MELLITUS

Mandala Of Health ◽

10.20884/1.mandala.2017.8.1.347 ◽

2017 ◽

Vol 8 (1) ◽

pp. 585

Author(s):

Radita Ikapratiwi ◽

Indah Rahmawati ◽

Joko Mulyanto

Keyword(s):

Diabetes Mellitus ◽

Relative Risk ◽

Pulmonary Tuberculosis ◽

Total Sample ◽

Sputum Smear ◽

Fisher Exact Test ◽

Exact Test ◽

Pulmonary Tb ◽

Smear Positive Pulmonary Tuberculosis ◽

Sputum Conversion

Tuberculosis (TB) is considered as the leading killer among infectious diseases because of bacteria resulted in a high number ofmorbidity and mortality world wide. One risk factor for tuberculosisis diabetes mellitus (DM). The prevalence of TB and DM jump together globally, especially in developing countries, including Indonesia. Early and accurate diagnosis of TB cases in the enforcement is sputum smear examination. Monitoring of TB seen through sputum conversion. The purpose of this studyis to determine the duration of sputum conversion difference new case smear positive pulmonary TB patients with and without DM in hospital Prof. Dr.Margono Soekarjo (RSMS) Purwokerto. Thestudy design is observational analytic with cohort retrospective study. Sample of this study was patients who checked their health in Lung Clinis of RSMS Purwokerto obtained total sample of 44 people, consisting of 22 patients clinically diagnosed new cases smear-positive pulmonary TB with DM and 22 patients without DM in 2009 until 2012.Results of this study were analyzed using Fisher Exact Test. pvalues obtainedof 0.000 (p <0.05) (95% CI = 0,288-0,718) with relative risk 0,455. The conclusion is there were significant differences in sputum conversion time between the group of patients suffering from pulmonary uberculosis with and without DM. The conversion of sputum in patients with pulmonary tuberculosis who suffered DM is longer than patients without DM. Relative risk value which is equal to 0.455 which means that patients with DM have pulmonary tuberculosis risk by 0.455 times more likely to experience delays in sputum conversion than TB patients without DM

Download Full-text

Abstract #244 A Comparative Study of Sputum Conversion Rate Among Diabetic and Non-Diabetic Patients with Newly Diagnosed Sputum Smear Positive Pulmonary Tuberculosis

Endocrine Practice ◽

10.1016/s1530-891x(20)46588-7 ◽

2019 ◽

Vol 25 ◽

pp. 90

Author(s):

L. Sreenivasamurthy ◽

Sindu Nagaraj

Keyword(s):

Pulmonary Tuberculosis ◽

Comparative Study ◽

Conversion Rate ◽

Sputum Smear ◽

Diabetic Patients ◽

Newly Diagnosed ◽

Smear Positive Pulmonary Tuberculosis ◽

Sputum Conversion

Download Full-text

Socio-clinico-radiological profile of smear-positive pulmonary tuberculosis patients in association with sputum conversion and baseline hsCRP levels

Tropical Doctor ◽

10.1177/00494755211042127 ◽

2021 ◽

pp. 004947552110421

Author(s):

S Krishna Singha ◽

Bineeta Kashyap ◽

Rajnish Avasthi ◽

Puneeta Hyanki ◽

NP Singh ◽

...

Keyword(s):

Pulmonary Tuberculosis ◽

Inflammatory Marker ◽

High Sensitivity ◽

C Reactive Protein ◽

Baseline Serum ◽

Tuberculosis Patients ◽

Protein Levels ◽

Reactive Protein ◽

Smear Positive Pulmonary Tuberculosis ◽

Sputum Conversion

Our was an observational follow-up study where the aim was to assess the baseline high-sensitivity C-reactive protein levels in 50 smear-positive pulmonary tuberculosis patients in association with socio-clinico-radiological profile and microbiological conversion. Smear and culture conversion of sputum samples at the end of intensive phase of anti-tubercular treatment were recorded. Baseline serum high-sensitivity C-reactive protein estimation was done by ELISA. Mean high-sensitivity C-reactive protein levels at baseline, smear/culture converted and delayed converters were 68.1 ± 22.2 mg/l, 66.7 ± 22.0 mg/l and 91.6 ± 6.7 mg/l, respectively; high-sensitivity C-reactive protein levels were significantly higher in delayed converters as compared to sputum converters. Significantly higher baseline high-sensitivity C-reactive protein levels were seen in patients with bilateral chest X-ray lesions, cavitations, evening rise of temperature, haemoptysis and dyspnoea as compared to those without these features. high-sensitivity C-reactive protein, being a non-specific inflammatory marker could be an adjunct tool for TB prognosis.

Download Full-text