scholarly journals Clinical Utility of Infection Control Documentation of Prior Methicillin-Resistant Staphylococcus aureus Colonization or Infection for Optimization of Empirical Antibiotic Therapy

2008 ◽  
Vol 29 (10) ◽  
pp. 972-974 ◽  
Author(s):  
Marin L. Schweizer ◽  
Jon P. Furuno ◽  
Anthony D. Harris ◽  
Jessina C. McGregor ◽  
Kerri A. Thom ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Infection Control ◽  
Antibiotic Therapy ◽  
Odds Ratio ◽  
Clinical Utility ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Empirical Therapy ◽  
Empirical Antibiotic Therapy ◽  
Methicillin Resistant ◽  
Mrsa Colonization

This 5-year study of 25,378 hospitalizations measured the utility of infection control documentation of prior methicillin-resistant Staphylococcus aureus (MRSA) colonization or infection for the optimization of empirical antibiotic therapy. Documented prior MRSA colonization or infection was predictive of subsequent MRSA infections (odds ratio, 4.05). Physicians appear to use this documentation when prescribing empirical therapy for suspected bacteremia.

Residential Proximity to Large Numbers of Swine in Feeding Operations Is Associated with Increased Risk of Methicillin-Resistant Staphylococcus aureus Colonization at Time of Hospital Admission in Rural Iowa Veterans

2014 ◽  
Vol 35 (2) ◽  
pp. 190-192 ◽  
Author(s):  
Margaret Carrel ◽  
Marin L. Schweizer ◽  
Mary Vaughan Sarrazin ◽  
Tara C. Smith ◽  
Eli N. Perencevich
Keyword(s):  
Staphylococcus Aureus ◽  
Relative Risk ◽  
Confidence Interval ◽  
Odds Ratio ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Methicillin Resistant ◽  
Residential Proximity ◽  
Large Numbers ◽  
Increased Risk ◽  
Mrsa Colonization

Among 1,036 patients, residential proximity within 1 mile of large swine facilities was associated with nearly double the risk of methicillin-resistant Staphylococcus aureus (MRSA) colonization at admission (relative risk, 1.8786 [95% confidence interval, 1.0928-3.2289]; P = .0239) and, after controlling for multiple admissions and age, was associated with 1.2nearly triple the odds of MRSA colonization (odds ratio, 2.76 [95% confidence interval, 1.2728-5.9875]; P = .0101).

scholarly journals Association between Methicillin-Resistant Staphylococcus aureus Colonization and Infection May Not Differ by Age Group

2013 ◽  
Vol 34 (1) ◽  
pp. 93-95 ◽  
Author(s):  
Adebola O. Ajao ◽  
Anthony D. Harris ◽  
J. Kristie Johnson ◽  
Mary-Claire Roghmann ◽  
Eli N. Perencevich ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Confidence Interval ◽  
Odds Ratio ◽  
Adjusted Odds Ratio ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Age Group ◽  
Subsequent Infection ◽  
Methicillin Resistant ◽  
Mrsa Colonization

We assessed whether age modified the association between methicillin-resistant Staphylococcus aureus (MRSA) anterior nares colonization and subsequent infection. Among 7,405 patients (9,511 admissions), MRSA colonization was significantly associated with infection (adjusted odds ratio, 13.7 [95% confidence interval, 7.325.7]) but did not differ significantly by age group.

scholarly journals Prevalence of Methicillin Resistant Staphylococcus Aureus In Khwaja Yunus Ali Medical College Hospital

KYAMC Journal ◽  
2017 ◽  
Vol 7 (1) ◽  
pp. 673-677
Author(s):  
Abdullah Akhtar Ahmed ◽  
Shakhaowat Hossain ◽  
Babul Aktar ◽  
Nusrat Akhtar Juyee ◽  
SM Ali Hasan
Keyword(s):  
Staphylococcus Aureus ◽  
Tract Infection ◽  
Respiratory Tract ◽  
Infection Control ◽  
Respiratory Tract Infection ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Throat Swab ◽  
College Hospital ◽  
Methicillin Resistant ◽  
Medical College

Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of healthcare-associated infections. To combat the challenge of life threatening MRSA remains a primary focus of most hospital infection control programs6. This study is undertaken in Khwaja Yunus Ali Medical College Hospital to identify the MRSA for determination of its prevalence and is considered a component of an infection control program in many countries5.Methods: Three hundred seventy hospitalized patients of surgery and medicine departments were studied during 2015. Clinical information of the patients and their pus, wound swab, sputum, throat swab and CSF were cultured.Results: Out of 370 patients, pus and wound swab of 217 (59%) had wound infection, sputum and throat swab of 141 had respiratory tract infection (38%) and CSF of 12 (3.2%) had meningitis were aseptically collected and cultured. Staphylococcus aureus were isolated in 51% cases and out of them MRSA was identified in 72 (73%) cases. MRSA isolated in 50% cases of meningitis, 49% cases of respiratory tract infection and 29% cases of wound infection.Conclusion: Methicillin-resistant Staphylococcus aureus appeared as a common cause of major illness and death and impose serious economic costs on patients and hospitals of our area like other developing countries. Detection of MRSA was associated with more severe clinical presentation.KYAMC Journal Vol. 7, No.-1, Jul 2016, Page 673-677

Recurrent Methicillin-Resistant Staphylococcus Aureus Osteomyelitis: Combination Antibiotic Therapy with Evaluation by Serum Bactericidal Titers

1995 ◽  
Vol 29 (7-8) ◽  
pp. 694-697 ◽  
Author(s):  
Sherrie L Aspinall ◽  
David M Friedland ◽  
Victor L Yu ◽  
John D Rihs ◽  
Robert R Muder
Keyword(s):  
Staphylococcus Aureus ◽  
Back Pain ◽  
Antibiotic Therapy ◽  
Sedimentation Rate ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Blood Cultures ◽  
Low Back ◽  
Methicillin Resistant ◽  
Trough Concentrations

Objective: To report on a patient with recurrent methicillin-resistant Staphylococcus aureus (MRSA) osteomyelitis and bacteremia successfully treated with combination antibiotic therapy. Case Summary: Two sets of blood cultures from a 55-year-old man with fever, malaise, and low back pain grew MRSA. Radiologic studies of the spine showed bony changes consistent with osteomyelitis. Soon after completing 6 weeks of vancomycin, the patient experienced a recurrence of back pain. Laboratory values included an increase in the sedimentation rate to 53 mm/h and positive blood cultures for MRSA. Vancomycin, gentamicin, and rifampin were administered for 8 weeks. Serum inhibitory and bactericidal titers were more than 1:1024 for both the peak and trough concentrations. Radiologic studies of the spine showed healing osteomyelitis. Two years after completion of antibiotic therapy, the infection has not recurred. Discussion: Antibiotic therapy alone was attempted because the patient was considered a risky surgical candidate. Serum inhibitory and bactericidal titers documented the high in vivo activity of the vancomycin, gentamicin, and rifampin combination. Initiation of vancomycin therapy led to disappearance of the fever and back pain. Cure was documented by sustained normalization of the erythrocyte sedimentation rate and radiologic evidence of healing. Conclusions: Combination antibiotic therapy with vancomycin, rifampin, and low-dose gentamicin (1 mg/kg q12h) may be useful for deep-seated tissue infection caused by MRSA.

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