scholarly journals Differences in Hospital-Associated Multidrug-Resistant Organisms and Clostridium difficile Rates Using 2-Day versus 3-Day Definitions

2014 ◽  
Vol 35 (11) ◽  
pp. 1417-1420 ◽  
Author(s):  
Adrijana Gombosev ◽  
Salah E. Fouad ◽  
Eric Cui ◽  
Chenghua Cao ◽  
Leah Terpstra ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Clostridium Difficile ◽  
Infection Prevention ◽  
Prevention Programs ◽  
Multidrug Resistant ◽  
Infect Control Hosp ◽  
Methicillin Resistant ◽  
Vancomycin Resistant Enterococci ◽  
Multidrug Resistant Organisms ◽  
Vancomycin Resistant

We surveyed infection prevention programs in 16 hospitals for hospital-associated methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci, extended-spectrum β-lactamase, and multidrug-resistant Acinetobacter acquisition, as well as hospital-associated MRSA bacteremia and Clostridium difficile infection based on defining events as occurring >2 days versus >3 days after admission. The former resulted in significantly higher median rates, ranging from 6.76% to 45.07% higherInfect Control Hosp Epidemiol 2014;35(11):1417–1420

Can alternative anatomical sites and environmental surveillance replace perianal screening for multidrug-resistant organisms in nursing homes?

2021 ◽  
pp. 1-4
Author(s):  
Kyle J. Gontjes ◽  
Kristen E. Gibson ◽  
Bonnie Lansing ◽  
Marco Cassone ◽  
Lona Mody
Keyword(s):  
Staphylococcus Aureus ◽  
Nursing Homes ◽  
Multidrug Resistant ◽  
Environmental Surveillance ◽  
Healthy Participant ◽  
Gram Negative ◽  
Methicillin Resistant ◽  
Vancomycin Resistant Enterococci ◽  
Multidrug Resistant Organisms ◽  
Vancomycin Resistant

Abstract Perianal screening can be intrusive. The sensitivities of multianatomical, nonperianal surveillance were 92.3% for methicillin-resistant Staphylococcus aureus (MRSA), 58.7% for vancomycin-resistant enterococci (VRE), and 54.9% for resistant Gram-negative bacilli (R-GNB). Sensitivities improved upon adding environmental surveillance (95.5%, 82.9%, and 67.9%, respectively). Multianatomical, nonperianal screening and room environment surveillance may replace perianal screening and reduce healthy participant bias in nursing homes.

Contamination of Hospital Curtains With Healthcare-Associated Pathogens

2008 ◽  
Vol 29 (11) ◽  
pp. 1074-1076 ◽  
Author(s):  
Floyd Trillis ◽  
Elizabeth C. Eckstein ◽  
Rachel Budavich ◽  
Michael J. Pultz ◽  
Curtis J. Donskey
Keyword(s):  
Staphylococcus Aureus ◽  
Clostridium Difficile ◽  
Methicillin Resistant ◽  
Potential Source ◽  
Vancomycin Resistant Enterococci ◽  
Vancomycin Resistant ◽  
Healthcare Associated

In a culture survey, we found that 42% of hospital privacy curtains were contaminated with vancomycin-resistant enterococci, 22% with methicillin-resistant Staphylococcus aureus, and 4% with Clostridium difficile. Hand imprint cultures demonstrated that these pathogens were easily acquired on hands. Hospital curtains are a potential source for dissemination of healthcare-associated pathogens.

Prevention of Infections with Multidrug-Resistant (MDR) Organisms

2019 ◽  
pp. 141-172
Author(s):  
Lorry G. Rubin ◽  
Gholamabbas Amin Ostovar
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Therapy ◽  
Antimicrobial Agents ◽  
Multidrug Resistant ◽  
Gram Negative ◽  
Methicillin Resistant ◽  
Environmental Cleaning ◽  
Multidrug Resistant Organisms ◽  
Vancomycin Resistant ◽  
Prevention Of Infections

Multidrug-resistant organisms (MDROs) may cause infections in pediatric patients that are severe and difficult to treat because of a limited armamentarium of antimicrobial agents. For most infections, antimicrobial therapy is initiated empirically prior to the results of cultures and susceptibility testing, and commonly prescribed empiric choices lack activity against MDR pathogens. This may result in a delay of initiation of antimicrobial therapy active against the pathogen and an increase in morbidity and mortality. Therefore, prevention of transmission and infection with MDROs is of paramount importance. This chapter reviews strategies to prevent transmission of multidrug-resistant organisms, specifically focusing on bacterial pathogens: methicillin-resistant Staphylococcus aureus (MRSA), gram-negative bacilli (GNB), and vancomycin-resistant enterococci (VRE). Isolation precautions, laboratory screening for colonization, and environmental cleaning are emphasized. Decolonization strategies for MRSA are described.

scholarly journals 7-O-Malonyl Macrolactin A, a New Macrolactin Antibiotic from Bacillus subtilis Active against Methicillin-Resistant Staphylococcus aureus, Vancomycin-Resistant Enterococci, and a Small-Colony Variant of Burkholderia cepacia

2006 ◽  
Vol 50 (5) ◽  
pp. 1701-1709 ◽  
Author(s):  
Magally Romero-Tabarez ◽  
Rolf Jansen ◽  
Marita Sylla ◽  
Heinrich Lünsdorf ◽  
Susanne Häußler ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Bacillus Subtilis ◽  
Burkholderia Cepacia ◽  
Multidrug Resistant ◽  
Methicillin Resistant ◽  
Small Colony Variant ◽  
Vancomycin Resistant Enterococci ◽  
Macrolactin A ◽  
Small Colony ◽  
Vancomycin Resistant

ABSTRACT We report here the discovery, isolation, and chemical and preliminary biological characterization of a new antibiotic compound, 7-O-malonyl macrolactin A (MMA), produced by a Bacillus subtilis soil isolate. MMA is a bacteriostatic antibiotic that inhibits a number of multidrug-resistant gram-positive bacterial pathogens, including methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and a small-colony variant of Burkholderia cepacia. MMA-treated staphylococci and enterococci were pseudomulticellular and exhibited multiple asymmetric initiation points of septum formation, indicating that MMA may inhibit a cell division function.

Enhanced disinfection leads to reduction of microbial contamination and a decrease in patient colonization and infection

2018 ◽  
Vol 39 (9) ◽  
pp. 1118-1121 ◽  
Author(s):  
William A. Rutala ◽  
Hajime Kanamori ◽  
Maria F. Gergen ◽  
Lauren P. Knelson ◽  
Emily E. Sickbert-Bennett ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Clostridium Difficile ◽  
Prospective Study ◽  
Microbial Contamination ◽  
Multidrug Resistant ◽  
Standard Practice ◽  
Vancomycin Resistant Enterococci ◽  
Vancomycin Resistant ◽  
Subsequent Patient

AbstractIn this prospective study, we monitored 4 epidemiologically important pathogens (EIPs): methicillin-resistane Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), Clostridium difficile, and multidrug-resistant (MDR) Acinetobacter to assess the effectiveness of 3 enhanced disinfection strategies for terminal room disinfection against standard practice. Our data demonstrated that a decrease in room contamination with EIPs of 94% was associated with a 35% decrease in subsequent patient colonization and/or infection.

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