7-O-Malonyl Macrolactin A, a New Macrolactin Antibiotic from Bacillus subtilis Active against Methicillin-Resistant Staphylococcus aureus, Vancomycin-Resistant Enterococci, and a Small-Colony Variant of Burkholderia cepacia
2006 ◽
Vol 50
(5)
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pp. 1701-1709
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Keyword(s):
ABSTRACT We report here the discovery, isolation, and chemical and preliminary biological characterization of a new antibiotic compound, 7-O-malonyl macrolactin A (MMA), produced by a Bacillus subtilis soil isolate. MMA is a bacteriostatic antibiotic that inhibits a number of multidrug-resistant gram-positive bacterial pathogens, including methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and a small-colony variant of Burkholderia cepacia. MMA-treated staphylococci and enterococci were pseudomulticellular and exhibited multiple asymmetric initiation points of septum formation, indicating that MMA may inhibit a cell division function.
2014 ◽
Vol 35
(11)
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pp. 1417-1420
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2011 ◽
Vol 34
(1)
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pp. 147-152
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2006 ◽
Vol 43
(Supplement_2)
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pp. S70-S74
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2006 ◽
Vol 90
(6)
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pp. 1165-1182
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2003 ◽
Vol 31
(4)
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pp. 1175-1182
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2005 ◽
Vol 49
(6)
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pp. 2498-2500
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2015 ◽
Vol 48
(4)
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pp. 431-436
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