Correction for Volume 216, Table 1, p. 26, in the article titled “Mass culture and characterization of tumor cells from a naturally occurring invertebrate cancer model: applications for human and animal disease and environmental health.” Biol. Bull. 216(1): 23–39

2009 ◽  
Vol 216 (2) ◽  
pp. iv-iv
Author(s):  
Charles Walker ◽  
Anne Böttger ◽  
Joseph Mulkern ◽  
Emily Jerszyk ◽  
Marianne Litvaitis ◽  
...  
Keyword(s):  
Environmental Health ◽  
Tumor Cells ◽  
Mass Culture ◽  
Animal Disease ◽  
Cancer Model ◽  
Naturally Occurring

Mass Culture and Characterization of Tumor Cells From a Naturally Occurring Invertebrate Cancer Model: Applications for Human and Animal Disease and Environmental Health

2009 ◽  
Vol 216 (1) ◽  
pp. 23-39 ◽  
Author(s):  
Charles Walker ◽  
S. Anne Böttger ◽  
Joseph Mulkern ◽  
Emily Jerszyk ◽  
Marianne Litvaitis ◽  
...  
Keyword(s):  
Environmental Health ◽  
Tumor Cells ◽  
Mass Culture ◽  
Animal Disease ◽  
Cancer Model ◽  
Naturally Occurring

High Resolution Replication of Organoclay Surfaces

1982 ◽  
Vol 40 ◽  
pp. 576-577
Author(s):  
W. W. Barker ◽  
W. E. Rigsby ◽  
V. J. Hurst ◽  
W. J. Humphreys
Keyword(s):  
Clay Mineral ◽  
Organic Molecule ◽  
Organic Molecules ◽  
X Ray Diffraction ◽  
Xrd Pattern ◽  
X Ray ◽  
Naturally Occurring ◽  
Silicate Layers ◽  
Mineral Identification

Experimental clay mineral-organic molecule complexes long have been known and some of them have been extensively studied by X-ray diffraction methods. The organic molecules are adsorbed onto the surfaces of the clay minerals, or intercalated between the silicate layers. Natural organo-clays also are widely recognized but generally have not been well characterized. Widely used techniques for clay mineral identification involve treatment of the sample with H2 O2 or other oxidant to destroy any associated organics. This generally simplifies and intensifies the XRD pattern of the clay residue, but helps little with the characterization of the original organoclay. Adequate techniques for the direct observation of synthetic and naturally occurring organoclays are yet to be developed.

Asbestos and Other Fibrous Materials

1989 ◽  
Author(s):  
H. Catherine W. Skinner ◽  
Malcolm Ross ◽  
Clifford Frondel
Keyword(s):  
Environmental Health ◽  
Inorganic Materials ◽  
Health Hazards ◽  
General Description ◽  
Fibrous Materials ◽  
Legal Professionals ◽  
Naturally Occurring

This comprehensive sourcebook describes the chemical, physical, and mineralogical aspects of fibrous inorganic materials, both synthetic and naturally occurring. A general description of the fibrous state, the range of compounds that can adopt this form, and an overview of the characteristics unique to such materials form the backbone of the book . The authors also assess the application and use of asbestos and other fibrous materials in industry and evaluate their potential as health hazards. The information gathered here will be highly useful to medical investigators and legal professionals involved in environmental health.

scholarly journals Exploiting the Amazing Diversity of Natural Source-Derived Polysaccharides: Modern Procedures of Isolation, Engineering, and Optimization of Antiviral Activities

Polymers ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 136
Author(s):  
Bimalendu Ray ◽  
Martin Schütz ◽  
Shuvam Mukherjee ◽  
Subrata Jana ◽  
Sayani Ray ◽  
...  
Keyword(s):  
Structural Characteristics ◽  
Antiviral Drug ◽  
Natural Source ◽  
Target Interaction ◽  
Charge Densities ◽  
Linkage Pattern ◽  
Naturally Occurring ◽  
Antiviral Activities ◽  
One Step

Naturally occurring polysaccharide sulfates are highly diverse, owning variations in the backbone structure, linkage pattern and stereochemistry, branching diversity, sulfate content and positions of sulfate group(s). These structural characteristics bring about diverse sulfated polymers with dissimilar negative charge densities and structure–activity relationships. Herein, we start with a short discussion of techniques needed for extraction, purification, chemical sulfation, and structural characterization of polysaccharides. Processes of isolation and sulfation of plant-derived polysaccharides are challenging and usually involve two steps. In this context, we describe an integrated extraction-sulfation procedure that produces polysaccharide sulfates from natural products in one step, thereby generating additional pharmacological activities. Finally, we provide examples of the spectrum of natural source-derived polysaccharides possessing specific features of bioactivity, in particular focusing on current aspects of antiviral drug development and drug–target interaction. Thus, the review presents a detailed view on chemically engineered polysaccharides, especially sulfated derivatives, and underlines their promising biomedical perspectives.

scholarly journals Semi-Synthesis of Small Molecules of Aminocarbazoles: Tumor Growth Inhibition and Potential Impact on p53

Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1637
Author(s):  
Solida Long ◽  
Joana B. Loureiro ◽  
Carla Carvalho ◽  
Luís Gales ◽  
Lucília Saraiva ◽  
...  
Keyword(s):  
Growth Inhibition ◽  
Small Molecules ◽  
Tumor Cells ◽  
Mutant P53 ◽  
Wild Type ◽  
Naturally Occurring ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity ◽  
Amino Derivatives ◽  
Carbazole Alkaloids

The tumor suppressor p53 is inactivated by mutation in approximately 50% of human cancers. Small molecules that bind and stabilize those mutants may represent effective anticancer drugs. Herein, we report the tumor cell growth inhibitory activity of carbazole alkaloids and amino derivatives, as well as their potential activation of p53. Twelve aminocarbazole alkaloids were semi-synthesized from heptaphylline (1), 7-methoxy heptaphylline (2), and 7-methoxymukonal (3), isolated from Clausena harmandiana, using a reductive amination protocol. Naturally-occurring carbazoles 1–3 and their amino derivatives were evaluated for their potential effect on wild-type and mutant p53 activity using a yeast screening assay and on human tumor cell lines. Naturally-occurring carbazoles 1–3 showed the most potent growth inhibitory effects on wild-type p53-expressing cells, being heptaphylline (1) the most promising in all the investigated cell lines. However, compound 1 also showed growth inhibition against non-tumor cells. Conversely, semi-synthetic aminocarbazole 1d showed an interesting growth inhibitory activity in tumor cells expressing both wild-type and mutant p53, exhibiting low growth inhibition on non-tumor cells. The yeast assay showed a potential reactivation of mutant p53 by heptaphylline derivatives, including compound 1d. The results obtained indicate that carbazole alkaloids may represent a promising starting point to search for new mutp53-reactivating agents with promising applications in cancer therapy.

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