The article deals with the problems of professional self-determination of a person in the conditions of transformation of social and labor relations and the labor market under the influence of the industrial revolution. The author identified the principle of contradictions as the main method of research, which makes it possible to clarify the problem field of the pro-cess of professional self-determination. To identify contradictions, the main theories and concepts that affect the division of labor and the transformation of social and labor relations are analyzed: the concept of the fourth industrial revolution, the digital economy, the innova-tion economy, the theory of human capital, human resource management, continuous Long-life learning (LLL), talent management. This allows us to identify trends in the devel-opment of social and labor relations as a factor of professional self-determination. The arti-cle considers the basic process of pro¬fessional self-determination as a continuous, multi-stage, cyclical, including stages: goals of professional self-determination, individual compe-tencies (strengths and weaknesses), supply and de¬mand in the labor market (current state and future), employment (form of employment), methods of competence development. One of the sources of contradictions the author sees the processes associated with the simulta-neous implementation of the principles of the third and fourth industrial revolutions in the Russian economy. Based on the analysis of theories and concepts, the article formulates eight main contradictions of professional self-determination, each of which has particular forms of manifestation. In the future on the basis of these contradictions is supposed to develop private mechanisms of professional self-determi¬nation of the person in choosing a profession, how and where competency development, place of work, shape and type of employment.