It would be useful to be able to determine the mechanical properties of bone using a noninvasive technique such as computed tomography (CT). However, in contrast to cancellous bone tissue, quantifying the elastic modulus of cortical bone from bone density and CT number has not been investigated extensively. This study measured the elastic moduli of cortical bone from eight bovine femora in the longitudinal, circumferential, and radial directions using mechanical compressive testing. Before testing, the CT number and wet apparent bone density were obtained. The experimentally determined coefficient of determination between CT number and bone density was around 0.6. Bone density was a good predictor of the elastic modulus of cortical bone in the longitudinal direction (r2 > 0.79), but it could not be used to predict the elastic moduli in the circumferential (r2 < 0.4) and radial (r2 < 0.22) directions. The coefficient of determination between CT number and the elastic modulus in the longitudinal direction was higher than 0.41. However, the correlations between CT number and elastic moduli were weak in the circumferential (r2 < 0.21) and radial (r2 < 0.19) directions. Moreover, the elastic modulus was much higher in the longitudinal direction than the circumferential and radial directions, and hence cortical bone can be considered a transversely isotropic property.
Variation of Nanostructures, Molecular Interactions, and Anisotropic Elastic Moduli of Lignocellulosic Cell Walls with Moisture