scholarly journals On the robustness of deep learning-based lung-nodule classification for CT images with respect to image noise

2020 ◽  
Vol 65 (24) ◽  
pp. 245037
Author(s):  
Chenyang Shen ◽  
Min-Yu Tsai ◽  
Liyuan Chen ◽  
Shulong Li ◽  
Dan Nguyen ◽  
...  
Keyword(s):  
Deep Learning ◽  
Lung Nodule ◽  
Ct Images ◽  
Image Noise ◽  
Nodule Classification

Improving robustness of a deep learning-based lung-nodule classification model of CT images with respect to image noise

2021 ◽  
Author(s):  
Yin Gao ◽  
Jennifer Xiong ◽  
Chenyang Shen ◽  
Xun Jia
Keyword(s):  
Medical Image Analysis ◽  
Lung Nodule ◽  
Ct Images ◽  
Image Noise ◽  
Classification Model ◽  
Noise Power ◽  
Ct Image ◽  
Hinge Loss ◽  
Svm Model ◽  
Nodule Classification

Abstract Objective: Robustness is an important aspect to consider, when developing methods for medical image analysis. This study investigated robustness properties of deep neural networks (DNNs) for a lung nodule classification problem based on CT images and proposed a solution to improve robustness. Approach: We firstly constructed a class of four DNNs with different widths, each predicting an output label (benign or malignant) for an input CT image cube containing a lung nodule. These networks were trained to achieve Area Under the Curve of 0.891-0.914 on a testing dataset. We then added to the input CT image cubes noise signals generated randomly using a realistic CT image noise model based on a noise power spectrum at 100 mAs, and monitored the DNN’s output change. We defined $SAR_{5} (\%)$ to quantify the robustness of the trained DNN model, indicating that for $5\%$ of CT image cubes, the noise can change the prediction results with a chance of at least $SAR_{5} (\%)$. To understand robustness, we viewed the information processing pipeline by the DNN as a two-step process, with the first step using all but the last layers to extract representations of the input CT image cubes in a latent space, and the second step employing the last fully-connected layer as a linear classifier to determine the position of the sample representations relative to a decision plane. To improve robustness, we proposed to retrain the last layer of the DNN with a Supporting Vector Machine (SVM) hinge loss function to enforce the desired position of the decision plane. Main results: $SAR_{5}$ ranged in $47.0\sim 62.0\%$ in different DNNs. The unrobustness behavior may be ascribed to the unfavorable placement of the decision plane in the latent representation space, which made some samples be perturbed to across the decision plane and hence susceptible to noise. The DNN-SVM model improved robustness over the DNN model and reduced $SAR_{5}$ by $8.8\sim 21.0\%$. Significance: This study provided insights about the potential reason for the unrobustness behavior of DNNs and the proposed DNN-SVM model improved model robustness.

scholarly journals Knowledge-based Collaborative Deep Learning for Benign-Malignant Lung Nodule Classification on Chest CT

2019 ◽  
Vol 38 (4) ◽  
pp. 991-1004 ◽  
Author(s):  
Yutong Xie ◽  
Yong Xia ◽  
Jianpeng Zhang ◽  
Yang Song ◽  
Dagan Feng ◽  
...  
Keyword(s):  
Deep Learning ◽  
Lung Nodule ◽  
Chest Ct ◽  
Knowledge Based ◽  
Nodule Classification

scholarly journals Application of Deep Learning in Lung Cancer Imaging Diagnosis

2022 ◽  
Vol 2022 ◽  
pp. 1-12
Author(s):  
Wenfa Jiang ◽  
Ganhua Zeng ◽  
Shuo Wang ◽  
Xiaofeng Wu ◽  
Chenyang Xu
Keyword(s):  
Lung Cancer ◽  
Computer Vision ◽  
Deep Learning ◽  
Malignant Tumors ◽  
Lung Nodule ◽  
Ct Images ◽  
Lung Nodules ◽  
X Rays ◽  
Imaging Diagnosis ◽  
Risk Of Cancer

Lung cancer is one of the malignant tumors with the highest fatality rate and nearest to our lives. It poses a great threat to human health and it mainly occurs in smokers. In our country, with the acceleration of industrialization, environmental pollution, and population aging, the cancer burden of lung cancer is increasing day by day. In the diagnosis of lung cancer, Computed Tomography (CT) images are a fairly common visualization tool. CT images visualize all tissues based on the absorption of X-rays. The diseased parts of the lung are collectively referred to as pulmonary nodules, the shape of nodules is different, and the risk of cancer will vary with the shape of nodules. Computer-aided diagnosis (CAD) is a very suitable method to solve this problem because the computer vision model can quickly scan every part of the CT image of the same quality for analysis and will not be affected by fatigue and emotion. The latest advances in deep learning enable computer vision models to help doctors diagnose various diseases, and in some cases, models have shown greater competitiveness than doctors. Based on the opportunity of technological development, the application of computer vision in medical imaging diagnosis of diseases has important research significance and value. In this paper, we have used a deep learning-based model on CT images of lung cancer and verified its effectiveness in the timely and accurate prediction of lungs disease. The proposed model has three parts: (i) detection of lung nodules, (ii) False Positive Reduction of the detected nodules to filter out “false nodules,” and (iii) classification of benign and malignant lung nodules. Furthermore, different network structures and loss functions were designed and realized at different stages. Additionally, to fine-tune the proposed deep learning-based mode and improve its accuracy in the detection Lung Nodule Detection, Noudule-Net, which is a detection network structure that combines U-Net and RPN, is proposed. Experimental observations have verified that the proposed scheme has exceptionally improved the expected accuracy and precision ratio of the underlined disease.

scholarly journals Influence of a novel deep-learning based reconstruction software on the objective and subjective image quality in low-dose abdominal computed tomography

2021 ◽  
Vol 94 (1117) ◽  
pp. 20200677
Author(s):  
Andrea Steuwe ◽  
Marie Weber ◽  
Oliver Thomas Bethge ◽  
Christin Rademacher ◽  
Matthias Boschheidgen ◽  
...  
Keyword(s):  
Deep Learning ◽  
Image Quality ◽  
Dose Reduction ◽  
Low Dose ◽  
Ct Images ◽  
Image Noise ◽  
The Novel ◽  
Subjective Image Quality ◽  
Image Information ◽  
Noise Ratio

Objectives: Modern reconstruction and post-processing software aims at reducing image noise in CT images, potentially allowing for a reduction of the employed radiation exposure. This study aimed at assessing the influence of a novel deep-learning based software on the subjective and objective image quality compared to two traditional methods [filtered back-projection (FBP), iterative reconstruction (IR)]. Methods: In this institutional review board-approved retrospective study, abdominal low-dose CT images of 27 patients (mean age 38 ± 12 years, volumetric CT dose index 2.9 ± 1.8 mGy) were reconstructed with IR, FBP and, furthermore, post-processed using a novel software. For the three reconstructions, qualitative and quantitative image quality was evaluated by means of CT numbers, noise, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) in six different ROIs. Additionally, the reconstructions were compared using SNR, peak SNR, root mean square error and mean absolute error to assess structural differences. Results: On average, CT numbers varied within 1 Hounsfield unit (HU) for the three assessed methods in the assessed ROIs. In soft tissue, image noise was up to 42% lower compared to FBP and up to 27% lower to IR when applying the novel software. Consequently, SNR and CNR were highest with the novel software. For both IR and the novel software, subjective image quality was equal but higher than the image quality of FBP-images. Conclusion: The assessed software reduces image noise while maintaining image information, even in comparison to IR, allowing for a potential dose reduction of approximately 20% in abdominal CT imaging. Advances in knowledge: The assessed software reduces image noise by up to 27% compared to IR and 48% compared to FBP while maintaining the image information. The reduced image noise allows for a potential dose reduction of approximately 20% in abdominal imaging.

An Early Prediction and Classification of Lung Nodule Diagnosis on CT Images Based on Hybrid Deep Learning Techniques

2022 ◽  
Author(s):  
Vijay Kumar Gugulothu ◽  
Savadam Balaji
Keyword(s):  
Computed Tomography ◽  
Lung Cancer ◽  
Deep Learning ◽  
Early Stage ◽  
Selection Process ◽  
Lung Nodule ◽  
Lung Cancer Screening ◽  
Ct Images ◽  
Learning Techniques ◽  
Feature Extraction And Selection

Abstract Detection of malignant lung nodules at an early stage may allow for clinical interventions that increase the survival rate of lung cancer patients. The use of hybrid deep learning techniques to detect nodules will improve the sensitivity of lung cancer screening and the interpretation speed of lung scans.Accurate detection of lung nodes is an important step in computed tomography (CT) imaging to detect lung cancer. However, it is very difficult to identify strong nodes due to the diversity of lung nodes and the complexity of the surrounding environment.Here, we proposed alung nodule detection and classification with CT images based on hybrid deep learning (LNDC-HDL) techniques. First, we introduce achaotic bird swarm optimization (CBSO) algorithm for lung nodule segmentation using statistical information. Second, we illustrate anImproved Fish Bee (IFB) algorithm for feature extraction and selection process. Third, we develop hybrid classifier i.e. hybrid differential evolution based neural network (HDE-NN) for tumor prediction and classification.Experimental results have shown that the use of computed tomography, which demonstrates the efficiency and importance of the HDE-NN specific structure for detecting lung nodes on CT scans, increases sensitivity and reduces the number of false positives. The proposed method shows that the benefits of HDE-NN node detection can be reaped by combining clinical practice.

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