Detecting and classifying neurotransmitter signals from ultra-high sensitivity PET data: the future of molecular brain imaging

As automobile manufacturers have begun to design, engineer, and test autonomous driving systems of the future, brain imaging with functional near-infrared spectroscopy (fNIRS) can provide unique insights about cognitive processes associated with evolving levels of autonomy implemented in the automobile. Modern fNIRS devices provide a portable, relatively affordable, and robust form of functional neuroimaging that allows researchers to investigate brain function in real-world environments. The trend toward “naturalistic neuroscience” is evident in the growing number of studies that leverage the methodological flexibility of fNIRS, and in doing so, significantly expand the scope of cognitive function that is accessible to observation via functional brain imaging (i.e., from the simulator to on-road scenarios). While more than a decade’s worth of study in this field of fNIRS driving research has led to many interesting findings, the number of studies applying fNIRS during autonomous modes of operation is limited. To support future research that directly addresses this lack in autonomous driving research with fNIRS, we argue that a cogent distillation of the methods used to date will help facilitate and streamline this research of tomorrow. To that end, here we provide a methodological review of the existing fNIRS driving research, with the overarching goal of highlighting the current diversity in methodological approaches. We argue that standardization of these approaches will facilitate greater overlap of methods by researchers from all disciplines, which will, in-turn, allow for meta-analysis of future results. We conclude by providing recommendations for advancing the use of such fNIRS technology in furthering understanding the adoption of safe autonomous vehicle technology.

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Commentary on ‘tools for optimizing pharmacotherapy in psychiatry (therapeutic drug monitoring, molecular brain imaging and pharmacogenetic tests): focus on antidepressants’

Pharmacogenomics ◽

10.2217/pgs-2021-0090 ◽

2021 ◽

Author(s):

Jose de Leon

Keyword(s):

Therapeutic Drug Monitoring ◽

Brain Imaging ◽

Drug Monitoring ◽

Therapeutic Drug ◽

Molecular Brain

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Review for "Oral contraceptives and serotonergic brain architecture: A molecular brain imaging study in healthy women"

10.1111/acps.13211/v1/review2 ◽

2020 ◽

Keyword(s):

Brain Imaging ◽

Oral Contraceptives ◽

Imaging Study ◽

Healthy Women ◽

Brain Architecture ◽

Molecular Brain ◽

Brain Imaging Study

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Marine Toxins Detection by Biosensors Based on Aptamers

Toxins ◽

10.3390/toxins12010001 ◽

2019 ◽

Vol 12 (1) ◽

pp. 1 ◽

Cited By ~ 3

Author(s):

Wei Ye ◽

Taomei Liu ◽

Weimin Zhang ◽

Muzi Zhu ◽

Zhaoming Liu ◽

...

Keyword(s):

Detection Limit ◽

Sensitivity And Specificity ◽

High Efficiency ◽

Rapid Development ◽

High Sensitivity ◽

Detection Methods ◽

Marine Toxins ◽

Time Saving ◽

Low Detection Limit ◽

The Future

Marine toxins cause great harm to human health through seafood, therefore, it is urgent to exploit new marine toxins detection methods with the merits of high sensitivity and specificity, low detection limit, convenience, and high efficiency. Aptasensors have emerged to replace classical detection methods for marine toxins detection. The rapid development of molecular biological approaches, sequencing technology, material science, electronics and chemical science boost the preparation and application of aptasensors. Taken together, the aptamer-based biosensors would be the best candidate for detection of the marine toxins with the merits of high sensitivity and specificity, convenience, time-saving, relatively low cost, extremely low detection limit, and high throughput, which have reduced the detection limit of marine toxins from nM to fM. This article reviews the detection of marine toxins by aptamer-based biosensors, as well as the selection approach for the systematic evolution of ligands by exponential enrichment (SELEX), the aptamer sequences. Moreover, the newest aptasensors and the future prospective are also discussed, which would provide thereotical basis for the future development of marine toxins detection by aptasensors.

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