scholarly journals Development and study on mechanical properties of small diameter artificial blood vessel by using electrospinning and 3d printing

2021 ◽  
Vol 2145 (1) ◽  
pp. 012037
Author(s):  
A Sukchanta ◽  
P Kummanee ◽  
W Nuansing
Keyword(s):  
Mechanical Properties ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
3D Printing ◽  
Blood Vessel ◽  
Small Diameter ◽  
Contact Angles ◽  
Artificial Blood ◽  
Artificial Blood Vessel ◽  
Artery Disease

Abstract The small diameter artificial blood vessel is synthesized with a diameter less than or equal to 6 millimetres. This technique has been used in coronary artery bypass grafting to treat coronary artery disease. Currently, the problem of coronary artery disease is still common, in addition to aortic aneurysm caused by the incompatibility of mechanical properties between the artificial blood vessel and the local blood vessel in the patient’s body. This research aims to solve the aforementioned problems using electrospinning and 3D printing technologies, as many types of materials are supported, all parameters are easy to change, and the cost is low. In this report, we describe a design for a small diameter polylactic acid (PLA) vascular graft fabricated by electrospinning with solutions of PLA in AC/DMF (1:1) 10, 12 and 15% w/v at 4 mm. The electrospun PLA nanofibers are tested for their morphology, contact angle, and seam strength. As the results, the fibres are still no same direction alignment due to insufficient rotation speed. The filament holding force is in the range of 1.90-2.71 N and the contact angles are greater than 90° because the samples are not wettable and have hydrophobic property. Further on, we will investigate other required properties, such as cell culture and other mechanical properties. Furthermore, we will compare the results with 3D printed artificial blood vessels with small diameter.

scholarly journals The relationship between mechanical properties of carotid artery and coronary artery disease

2011 ◽  
Vol 13 (7) ◽  
pp. 568-573 ◽  
Author(s):  
S.-A. Kim ◽  
S.-M. Park ◽  
M.-N. Kim ◽  
Y.-H. Kim ◽  
D.-H. Cho ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Carotid Artery ◽  
Artery Disease ◽  
The Relationship

Biomimetic Hemocompatible Nanofibrous Scaffolds as Potential Small-Diameter Blood Vessels by Bilayering Electrospun Technique

2011 ◽  
Vol 306-307 ◽  
pp. 1627-1630 ◽  
Author(s):  
He Yun Wang ◽  
Ya Kai Feng ◽  
Hai Yang Zhao ◽  
Ruo Fang Xiao ◽  
Jin Tang Guo
Keyword(s):  
Mechanical Properties ◽  
Blood Vessel ◽  
Breaking Strength ◽  
Small Diameter ◽  
Matrix Structure ◽  
Complex Matrix ◽  
Elongation At Break ◽  
Artificial Blood ◽  
Nanofibrous Scaffolds ◽  
Morphology And Mechanical Properties

In this paper, we prepared a scaffold composed of a polyurethane (PU) fibrous outside-layer and a gelatin-heparin fibrous inner-layer with mimicking morphology and mechanical properties of a native blood vessel by sequential bilayering electrospinning technology on a rotating mandrel-type collector. The scaffolds achieved the appropriate breaking strength (3.7 ± 0.13 MPa) and elongation at break (110 ± 8%). When the scaffolds were immersed in water for 1 h, the breaking strength decreased slightly to 2.2 ± 0.3 MPa, but the elongation at break increased up to 145 ± 21%. Heparin was released from the scaffolds at substantially uniform rate until the 9th day. The scaffolds were expected to mimic the complex matrix structure of native arteries, and had good hemocompatibility as an artificial blood vessel owing to the heparin release.

Large artery mechanical properties correlate with severity of coronary artery disease

2000 ◽  
Vol 9 (3) ◽  
pp. A155
Author(s):  
T.K. Waddell ◽  
T.L. Medley ◽  
C.D. Gatzka ◽  
J.D. Cameron ◽  
A.M. Dart ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Large Artery ◽  
Artery Disease

scholarly journals Radionuclide imaging methods in the diagnosis of microvascular dysfunction in non-obstructive coronary artery disease

2021 ◽  
Vol 26 (12) ◽  
pp. 4746
Author(s):  
A. N. Maltseva ◽  
A. V. Mochula ◽  
K. V. Kopyeva ◽  
E. V. Grakova ◽  
K. V. Zavadovsky
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Single Photon ◽  
Obstructive Coronary Artery Disease ◽  
Photon Emission ◽  
Small Diameter ◽  
Microvascular Dysfunction ◽  
Emission Computed Tomography ◽  
Flow Reserve ◽  
Artery Disease

Non-obstructive coronary artery disease is generally considered as a favorable type of pathology, however, a number of studies indicate that in non-obstructive atherosclerosis, the risk of such cardiovascular events as myocardial infarction, ischemic stroke, sudden cardiac death and decompensated heart failure cannot be completely ruled out. This may be due to microvascular dysfunction. However, due to the small diameter of vessels, none of the imaging techniques used in clinical practice makes it possible to assess microvascular morphology. To date, the most well-established methods for assessing myocardial perfusion are single-photon emission computed tomography (SPECT) and positron emission tomography (PET). The ability to quantify myocardial blood flow and coronary flow reserve allows SPECT and PET to be the methods of choice for non-invasive diagnosis of microvascular dysfunction. This review is devoted to current data on the clinical significance of radionuclide diagnosis of microvascular dysfunction in patients with non-obstructive coronary artery disease.

scholarly journals Improvement in the Mechanical Properties of Artificial Blood Vessel Suitable for the Extracranial Cerebral Artery

1990 ◽  
Vol 18 (1) ◽  
pp. 8-12
Author(s):  
Susumu MIYAMOTO ◽  
Haruhiko KIKUCHI ◽  
Yoshito IKADA ◽  
Masao MINATO ◽  
Keiji FUJIMOTO ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Blood Vessel ◽  
Cerebral Artery ◽  
Artificial Blood ◽  
Artificial Blood Vessel
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