Biomimetic Hemocompatible Nanofibrous Scaffolds as Potential Small-Diameter Blood Vessels by Bilayering Electrospun Technique

2011 ◽  
Vol 306-307 ◽  
pp. 1627-1630 ◽  
Author(s):  
He Yun Wang ◽  
Ya Kai Feng ◽  
Hai Yang Zhao ◽  
Ruo Fang Xiao ◽  
Jin Tang Guo
Keyword(s):  
Mechanical Properties ◽  
Blood Vessel ◽  
Breaking Strength ◽  
Small Diameter ◽  
Matrix Structure ◽  
Complex Matrix ◽  
Elongation At Break ◽  
Artificial Blood ◽  
Nanofibrous Scaffolds ◽  
Morphology And Mechanical Properties

In this paper, we prepared a scaffold composed of a polyurethane (PU) fibrous outside-layer and a gelatin-heparin fibrous inner-layer with mimicking morphology and mechanical properties of a native blood vessel by sequential bilayering electrospinning technology on a rotating mandrel-type collector. The scaffolds achieved the appropriate breaking strength (3.7 ± 0.13 MPa) and elongation at break (110 ± 8%). When the scaffolds were immersed in water for 1 h, the breaking strength decreased slightly to 2.2 ± 0.3 MPa, but the elongation at break increased up to 145 ± 21%. Heparin was released from the scaffolds at substantially uniform rate until the 9th day. The scaffolds were expected to mimic the complex matrix structure of native arteries, and had good hemocompatibility as an artificial blood vessel owing to the heparin release.

scholarly journals Development and study on mechanical properties of small diameter artificial blood vessel by using electrospinning and 3d printing

2021 ◽  
Vol 2145 (1) ◽  
pp. 012037
Author(s):  
A Sukchanta ◽  
P Kummanee ◽  
W Nuansing
Keyword(s):  
Mechanical Properties ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
3D Printing ◽  
Blood Vessel ◽  
Small Diameter ◽  
Contact Angles ◽  
Artificial Blood ◽  
Artificial Blood Vessel ◽  
Artery Disease

Abstract The small diameter artificial blood vessel is synthesized with a diameter less than or equal to 6 millimetres. This technique has been used in coronary artery bypass grafting to treat coronary artery disease. Currently, the problem of coronary artery disease is still common, in addition to aortic aneurysm caused by the incompatibility of mechanical properties between the artificial blood vessel and the local blood vessel in the patient’s body. This research aims to solve the aforementioned problems using electrospinning and 3D printing technologies, as many types of materials are supported, all parameters are easy to change, and the cost is low. In this report, we describe a design for a small diameter polylactic acid (PLA) vascular graft fabricated by electrospinning with solutions of PLA in AC/DMF (1:1) 10, 12 and 15% w/v at 4 mm. The electrospun PLA nanofibers are tested for their morphology, contact angle, and seam strength. As the results, the fibres are still no same direction alignment due to insufficient rotation speed. The filament holding force is in the range of 1.90-2.71 N and the contact angles are greater than 90° because the samples are not wettable and have hydrophobic property. Further on, we will investigate other required properties, such as cell culture and other mechanical properties. Furthermore, we will compare the results with 3D printed artificial blood vessels with small diameter.

scholarly journals Fabrication and Characterization of Electrospun Polycaprolactone Blended with Chitosan-Gelatin Complex Nanofibrous Mats

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Yongfang Qian ◽  
Zhen Zhang ◽  
Laijiu Zheng ◽  
Ruoyuan Song ◽  
Yuping Zhao
Keyword(s):  
Mechanical Properties ◽  
Tensile Strength ◽  
Weight Ratio ◽  
Degree Of Crystallinity ◽  
X Ray Diffraction ◽  
Tissue Engineering Scaffolds ◽  
Elongation At Break ◽  
Nanofibrous Scaffolds ◽  
Two Peaks

Design and fabrication of nanofibrous scaffolds should mimic the native extracellular matrix. This study is aimed at investigating electrospinning of polycaprolactone (PCL) blended with chitosan-gelatin complex. The morphologies were observed from scanning electron microscope. As-spun blended mats had thinner fibers than pure PCL. X-ray diffraction was used to analyze the degree of crystallinity. The intensity at two peaks at 2θof 21° and 23.5° gradually decreased with the percentage of chitosan-gelatin complex increasing. Moreover, incorporation of the complex could obviously improve the hydrophilicity of as-spun blended mats. Mechanical properties of as-spun nanofibrous mats were also tested. The elongation at break of fibrous mats increased with the PCL content increasing and the ultimate tensile strength varied with different weight ratios. The as-spun mats had higher tensile strength when the weight ratio of PCL to CS-Gel was 75/25 compared to pure PCL. Both as-spun PCL scaffolds and PCL/CS-Gel scaffolds supported the proliferation of porcine iliac endothelial cells, and PCL/CS-Gel had better cell viability than pure PCL. Therefore, electrospun PCL/Chitosan-gelatin nanofibrous mats with weight ratio of 75/25 have better hydrophilicity mechanical properties, and cell proliferation and thus would be a promising candidate for tissue engineering scaffolds.

The Effect of Drawing Process on the Properties of Split-Film PTFE Fiber

2012 ◽  
Vol 602-604 ◽  
pp. 1946-1950 ◽  
Author(s):  
Xin Min Hao ◽  
Yuan Yang ◽  
Bin Xiang Huang ◽  
Lei Huang ◽  
Guo Jun Zhang
Keyword(s):  
Mechanical Properties ◽  
Draw Ratio ◽  
Breaking Strength ◽  
Three Dimensional ◽  
Drawing Process ◽  
Heat Setting ◽  
Elongation At Break ◽  
Ptfe Membrane ◽  
Hot Drawing ◽  
Temperature Controlled

From PTFE baseband prepared by three-dimensional drawing, after the processing of different temperature and time. And then by twisting, hot drawing and heat setting, the PTFE filament was prepared in appropriate tension conditions. The surface morphology of the resulting filaments was observed by SEM, the result shows that the uniformity of the PTFE membrane has been improved by using three-dimensional drawing process, hot drawing processes had a great effect upon the breaking strength and elongation at break of PTFE fibers. In order to keep ensure reasonable mechanical properties, the draw ratio in the range of 20 to 50 times to adjust the temperature controlled at 150°C to 300 °C.

scholarly journals Improvement in the Mechanical Properties of Artificial Blood Vessel Suitable for the Extracranial Cerebral Artery

1990 ◽  
Vol 18 (1) ◽  
pp. 8-12
Author(s):  
Susumu MIYAMOTO ◽  
Haruhiko KIKUCHI ◽  
Yoshito IKADA ◽  
Masao MINATO ◽  
Keiji FUJIMOTO ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Blood Vessel ◽  
Cerebral Artery ◽  
Artificial Blood ◽  
Artificial Blood Vessel

Morphology and Mechanical Properties of LDPE, EVA and Fly Ash Composites

2020 ◽  
Vol 869 ◽  
pp. 76-81
Author(s):  
Vu Minh Trong ◽  
Bui Dinh Hoan
Keyword(s):  
Mechanical Properties ◽  
Fly Ash ◽  
Ethylene Vinyl Acetate ◽  
Low Density Polyethylene ◽  
Low Density ◽  
Melt Mixing ◽  
Elongation At Break ◽  
Acetate Copolymer ◽  
Ethylene Vinyl Acetate Copolymer ◽  
Morphology And Mechanical Properties

The fly ash from Pha Lai power plant was modified by vinyltrimetoxysilan (VTMS). The polymer composites based on low-density polyethylene (LDPE), ethylene vinyl acetate copolymer (EVA) and fly ash (FA) without and with vinyltrimetoxysilan (VTMS) modification were prepared by melt mixing in a Haake Rheomixer. The tensile strength and elongation at break of the LDPE/EVA/VFA composites were also higher than those of the LDPE/EVA/FA composites. The FESEM images proved that FA-VTMS particles disperse more regularly in the polymer matrix in comparison with FA without VTMS modification. In addition, the surface modification of the FA reduced the size of agglomeration of FA particles.

Preparation and Characterization of Poly(Vinyl Alcohol)(PVA)/Hydroxyapatite (HA) Nanofibrous Scaffolds

2011 ◽  
Vol 284-286 ◽  
pp. 459-463 ◽  
Author(s):  
Yuan Yuan Qi ◽  
Bin Liu ◽  
Xing Bin Yan
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Tensile Strength ◽  
Drug Delivery Systems ◽  
Poly Vinyl Alcohol ◽  
Elongation At Break ◽  
Nanofibrous Scaffolds ◽  
Potential Applications

Nanofibrous scaffolds of PVA and HA were prepared by electrospinning. SEM showed the scaffolds had porous nanofibrous morphology, and the diameter of the fibers was in the range of 200-1000 nm. FTIR and XRD showed the presence of HA in the scaffolds. The mechanical properties of the scaffolds changed by the adding content of HA. For the nanoscaffolds with 2wt % HA, the ultimate tensile strength and the elongation at break was 7.5 MPa and 17%. The PVA/HA nanoscaffolds prepared by electrospinning indicated good properties, and had a potential applications in bone tissue engineering and drug delivery systems.

scholarly journals Preparation of CaCO3-SiO2 composite with core-shell structure and its application in silicone rubber

2015 ◽  
Vol 17 (4) ◽  
pp. 128-133 ◽  
Author(s):  
Chenglin Cui ◽  
Hao Ding ◽  
Li Cao ◽  
Daimei Chen
Keyword(s):  
Mechanical Properties ◽  
Silicone Rubber ◽  
Shell Structure ◽  
Breaking Strength ◽  
Core Shell ◽  
Elongation At Break ◽  
Chemistry Method ◽  
Core Shell Structure

Abstract A new CaCO3-SiO2 composite with core-shell structure was successfully prepared by mechano-chemistry method (MCM). SEM and FTIR indicated that SiO2 particles were homogeneously immobilized on the surface of CaCO3. The well dispersion of this CaCO3-SiO2 composite into silicone rubber can not only reduce the usage amount of SiO2, but also improve the mechanical properties of silicone rubber. By the calculation, the theoretical numbers of the SiO2 particles is about 10 times as large as that of CaCO3 particles in the CaCO3-SiO2 composite. Mixing CaCO3-SiO2 composite in silicone rubber can enhance the breaking strength of the silicone rubber about 18% as high as that when mixing the pure SiO2. And the elongation at break is about 14% less than that of adding the pure SiO2 sample.

A simply prepared small-diameter artificial blood vessel that promotes in situ endothelialization

2017 ◽  
Vol 54 ◽  
pp. 107-116 ◽  
Author(s):  
Hong-Feng Guo ◽  
Wei-Wei Dai ◽  
De-Hui Qian ◽  
Zhe-Xue Qin ◽  
Yan Lei ◽  
...  
Keyword(s):  
Blood Vessel ◽  
Small Diameter ◽  
Artificial Blood ◽  
Artificial Blood Vessel
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