scholarly journals The influence of physical factors on recognizing blood cells in the computer microscopy systems of acute leukemia diagnosis

2017 ◽  
Vol 784 ◽  
pp. 012042 ◽  
Author(s):  
V G Nikitaev ◽  
A N Pronichev ◽  
E V Polyakov ◽  
V V Dmitrieva ◽  
N N Tupitsyn ◽  
...  
Keyword(s):  
Acute Leukemia ◽  
Blood Cells ◽  
Physical Factors ◽  
Leukemia Diagnosis ◽  
Computer Microscopy

scholarly journals History of Leukemia: Diagnosis and Treatment from Beginning to Now

2017 ◽  
Vol 6 (1) ◽  
pp. 12-22
Author(s):  
Sahar Mehranfar ◽  
Sirous Zeinali ◽  
Rana Hosseini ◽  
Mozhdeh Mohammadian ◽  
Abolfazl Akbarzadeh ◽  
...  
Keyword(s):  
Acute Leukemia ◽  
Blood Cells ◽  
Lymphoblastic Leukemia ◽  
Diagnosis And Treatment ◽  
Cooperative Effort ◽  
Leukemia Diagnosis ◽  
History Of ◽  
The 19Th Century ◽  
Long Term Survivors

In 1845, leukemia was known as a systemic illness; and it was more than 100 years later that the first report of a significant therapy for leukemia was published in 1948. Leukemia was known as a multifactorial disease rather than a single disease till 1900. In 1965, less than 1% of children with acute leukemia were predictable to have long-term survivors; today, approximately 80% of children and adolescents with acute lymphoblastic leukemia are cured, these achievements are due to the cooperative effort of researchers and physicians in the field. Despite this success, leukemia is still the leading cause of death globally. This review aims to elucidate the history of leukemia from the beginning of the 19th century when scientists defined unusual disorders of the blood cells, till present. Additionally, we tried to discuss the history of the diagnosis and treatment of leukemia with particular emphasis on acute leukemia. [GMJ.2017;6(1):12-22]

METHODOLOGY FOR FORMING A DATABASE OF REFERENCE IMAGES OF BONE MARROW CELLS FOR THE AUTOMATED DIAGNOSIS OF ACUTE LEUKEMIA IN ONCOHEMATOLOGY

2021 ◽  
pp. 84-89
Author(s):  
Ольга Александровна Медведева ◽  
Святослав Николаевич Простаков ◽  
Николай Николаевич Тупицын ◽  
Александра Дмитриевна Палладина
Keyword(s):  
Bone Marrow ◽  
Acute Leukemia ◽  
Bone Marrow Cells ◽  
Digital Images ◽  
Automated Image Analysis ◽  
Medical Decision ◽  
Reference Images ◽  
Computer Microscopy ◽  
Marrow Cells

В статье представлено описание факторов, влияющих на качество формирования базы эталонных изображений клеток костного мозга для диагностики острых лейкозов с применением методов компьютерной микроскопии. Отмечена важность контроля качества подготовки препаратов и микроскопа для применения в автоматизированных системах анализа изображений. Рассмотрены особенности регистрации цифровых микроскопических изображений клеток костного мозга в системах компьютерной микроскопии. Исследовано влияние фокусировки оптической системы микроскопа и уровня освещения препарата на формирование цифровых изображений клеток костного мозга. Установлены требования к условиям регистрации цифровых изображений, используемых в автоматизированных системах микроскопического анализа препаратов костного мозга. Предложена концептуальная модель базы эталонных изображений костного мозга, являющаяся основой для разработки инструментов эффективного распознавания клеток костного мозга в системах компьютерной микроскопии. Следование указанным требованиям к регистрации изображений призвано обеспечить надлежащее качество эталонной базы, что имеет непосредственной влияние на повышение точности и достоверности медицинской диагностики с применением методов компьютерной микроскопии. Результаты работы могут быть использованы в системах поддержки принятия врачебных решений при диагностике острых лейкозов The article describes the factors affecting the quality of the formation of a database of reference images of bone marrow cells for the diagnosis of acute leukemia using computer microscopy methods. The importance of quality control of specimen and microscope preparation for use in automated image analysis systems is noted. The features of registration of digital microscopic images of bone marrow cells in computer microscopy systems are considered. The effect of focusing of the optical system of the microscope and the level of illumination of the specimen on the formation of digital images of bone marrow cells is investigated. The requirements for the conditions of registration of digital images used in automated systems of microscopic analysis of bone marrow preparations have been established. A conceptual model of the base of reference images of bone marrow is proposed. It is the basis for the development of tools for effective recognition of bone marrow cells in computer microscopy systems. Following the specified requirements for image registration is designed to ensure the proper quality of the reference base of images, which has a direct impact on improving the accuracy and reliability of medical diagnostics using computer microscopy. The results of the work can be used in medical decision support systems for the diagnosis of acute leukemia

scholarly journals Group-C Trisomy in Myeloid Metaplasia with Possible Leukemia

Blood ◽  
1964 ◽  
Vol 24 (6) ◽  
pp. 716-725 ◽  
Author(s):  
AVERY A. SANDBERG ◽  
TAKAAKI ISHIHARA ◽  
LOIS H. CROSSWHITE
Keyword(s):  
Bone Marrow ◽  
Blood Culture ◽  
Acute Leukemia ◽  
Chromosomal Abnormality ◽  
Blood Cells ◽  
Karyotype Analysis ◽  
Myeloproliferative Disorders ◽  
Normal Female ◽  
Myeloid Metaplasia ◽  
Definite Relationship

Abstract A chromosomal abnormality in marrow and blood cells has been found in only one patient out of a group of 20 subjects with myeloproliferative disorders other than leukemia. The abnormal karyotypic finding consisted of group C9 trisomy in a patient with myeloid metaplasia and an acute leukemia-like picture and indicates a definite relationship to acute leukemia. The latter has been shown to be not infrequently accompanied by C9 trisomy. The trisomy was accompanied by the presence of a substantial number of hypertetraploid cells in the marrow but not in the cultured blood cells. As a matter of fact, the blood culture yielded predominantly metaphases with 47 chromosomes (C9 trisomy) on the first examination and metaphases with 46 chromosomes and a normal female karyotype on the second occasion. The superiority of bone marrow karyotype analysis over that of blood cells in leukemic states is thus indicated.

Acute Leukemia: Diagnosis and Treatment

2019 ◽  
Vol 35 (6) ◽  
pp. 150950 ◽  
Author(s):  
Lisa M. Blackburn ◽  
Sarah Bender ◽  
Shelly Brown
Keyword(s):  
Acute Leukemia ◽  
Diagnosis And Treatment ◽  
Leukemia Diagnosis

Identification of complement C3f-desArg and its derivative for acute leukemia diagnosis and minimal residual disease assessment

PROTEOMICS ◽  
2010 ◽  
Vol 10 (1) ◽  
pp. 90-98 ◽  
Author(s):  
Tingting Liang ◽  
Na Wang ◽  
Wei Li ◽  
Ailing Li ◽  
Jie Wang ◽  
...  
Keyword(s):  
Acute Leukemia ◽  
Minimal Residual Disease ◽  
Residual Disease ◽  
Disease Assessment ◽  
Leukemia Diagnosis ◽  
Minimal Residual

What Are Normal Blood Values for Leukemia in Remission?

Blood ◽  
1959 ◽  
Vol 14 (4) ◽  
pp. 369-373 ◽  
Author(s):  
CAROL B. HYMAN ◽  
EDUARDO BORDA C. ◽  
GOPALASWAMI DIGUMARTHI
Keyword(s):  
Statistical Analysis ◽  
Acute Leukemia ◽  
Blood Cells ◽  
White Blood Cells ◽  
Hemoglobin Concentration ◽  
Normal Blood ◽  
Drug Induced ◽  
Normal Children

Abstract 1. The values for hemoglobin concentration, total white blood cells, granulocytes, lymphocytes and monocytes at the midpoint of 78 drug-induced remissions in a group of children with acute leukemia have been presented. These values have been compared with those from a group of normal children, and the differences analyzed statistically. 2. Statistical analysis shows that, in general, blood values in remission are reduced by the particular agent employed. White blood cells are more markedly affected than hemoglobin. 3. The effects are essentially the same with 6-M.P. given alone or in combination with azaserine or DON. 4. The reduction in values is greatest with 6-M.P., alone or in combination, less with amethopterin and least with prednisone. 5. The data presented indicate that criteria for complete blood remission should make allowances for the influence of the drug employed.

Fuzzy feature representation for white blood cell differential counting in acute leukemia diagnosis

2015 ◽  
Vol 13 (3) ◽  
pp. 742-752 ◽  
Author(s):  
Chastine Fatichah ◽  
Martin L. Tangel ◽  
Fei Yan ◽  
Janet P. Betancourt ◽  
M. Rahmat Widyanto ◽  
...  
Keyword(s):  
Blood Cell ◽  
Acute Leukemia ◽  
White Blood Cell ◽  
Feature Representation ◽  
Leukemia Diagnosis

scholarly journals Integrated information and measurement system for the diagnosis of acute leukemia and minimal residual disease based on computer microscopy, flow laser cytofluorimetry and artificial intelligence

2021 ◽  
Vol 2058 (1) ◽  
pp. 012033
Author(s):  
V G Nikitayev ◽  
A N Pronichev ◽  
N N Tupitsin ◽  
V Yu Selchuk ◽  
V V Dmitrieva ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Bone Marrow ◽  
Acute Leukemia ◽  
Minimal Residual Disease ◽  
Measurement System ◽  
Bone Marrow Cells ◽  
Residual Disease ◽  
Computer Microscopy ◽  
Minimal Residual ◽  
Integrated Information

Abstract The article considers a new integrated information and measurement system for the diagnosis of acute leukemia and minimal residual disease based on computer microscopy and flow laser cytometry. The system is based on combining the results of computer microscopy in the analysis of bone marrow preparations and the results of flow laser cytofluorimetry. A special feature of the system is the use of artificial intelligence technologies in the recognition of images of bone marrow cells in the computer microscopy subsystem. The work was the result of joint work of the Department of Computer Medical Systems of the National Research Nuclear University "MEPhI" and the Laboratory of Hematopoietic Immunology of the National Medical Research Center of Oncology named after N. N. Blokhin.

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