A Pharmacologic Study on the Mechanism of Action of Kakkon-to: Body Temperature Elevation and Phagocytic Activation of Macrophages in Dogs

2004 ◽  
Vol 10 (5) ◽  
pp. 841-849 ◽  
Author(s):  
Kenichi Muraoka ◽  
Satoshi Yoshida ◽  
Kazumasa Hasegawa ◽  
Nobuo Nakanishi ◽  
Isao Fukuzawa ◽  
...  
2004 ◽  
Vol 10 (5) ◽  
pp. 841-849
Author(s):  
Kenichi Muraoka ◽  
Satoshi Yoshida ◽  
Kazumasa Hasegawa ◽  
Nobuo Nakanishi ◽  
Isao Fukuzawa ◽  
...  

1994 ◽  
pp. 41-46 ◽  
Author(s):  
A. A. Romanovsky ◽  
C. M. Blatteis

2018 ◽  
Vol 78 ◽  
pp. 281-289 ◽  
Author(s):  
Yuki Uchida ◽  
Koyuki Atsumi ◽  
Shinji Hirano ◽  
Nao Koyanagi

PEDIATRICS ◽  
1973 ◽  
Vol 51 (2) ◽  
pp. 391-394
Author(s):  
Renate D. Kimbrough

The published data on the toxicity of hexachlorophene in animals and man are discussed. Studies performed in the author's laboratory including hexachlorophene blood level determinations in animals and man are also reviewed. Hexachlorophene can produce paralysis in rats, rabbits, cats, and pigs and blindness in sheep. Microscopic examination of the brains of rats and monkeys given repeated doses of hexachlorophene shows status spongiosus of the white matter and normal gray matter. Small amounts of hexachlorophene are absorbed through the skin of animals as well as man. Aside from the neurological effects of hexachlorophene, the chemical uncouples oxidative phosphorylation which may cause body temperature elevation.


1993 ◽  
Vol 265 (5) ◽  
pp. R1121-R1125
Author(s):  
P. J. Rowsey ◽  
K. T. Borer ◽  
M. J. Kluger

Female Sprague-Dawley rats (12:12-h photoperiod; body temperature, BT, measured with biotelemetry) with access to running wheels for 6 wk have an elevated BT (compared with rats with no access to exercise wheels, i.e, sedentary) both during the period of voluntary exercise (nighttime) (0.5 degree C, P = 0.0001) and the nonexercise period (daytime) (0.3 degree C, P = 0.002). To determine whether prostaglandin (PG) E was responsible for any portion of this daytime rise in BT, we injected a dose of sodium salicylate (300 mg/kg), which was shown to produce complete antipyresis in rats injected with lipopolysaccharide (LPS), into exercised and sedentary rats 4 h after the onset of the lights-on period. The injections of sodium salicylate led to a fall in body temperature in both the exercised and sedentary rats of similar amounts (-0.88 degree C vs. -0.61 degree C at 2 h postinjection, P = 0.59). We conclude that the increase in daytime BT of exercised female rats is not mediated by prostaglandins.


1980 ◽  
Vol 69 (3) ◽  
pp. 299-305 ◽  
Author(s):  
J. A. Davies ◽  
J. D. P. Graham

1985 ◽  
Vol 109 (4) ◽  
pp. 458-462 ◽  
Author(s):  
Stig Engkjær Christensen ◽  
Otto Jørgensen ◽  
Jan Møller ◽  
Niels Møller ◽  
Hans Ørskov

Abstract. Ten young healthy normal-weight males were studied in four test situations designed to elucidate the relative role of body temperature increase vs that of exercise per se for pituitary hormone release. Tympanic temperature was recorded continuously during the tests. Elevation of body temperature at rest induced by external heating resulted in parallel changes in serum prolactin (Prl), also found when temperature spontaneously returned towards normal. In contrast, temperature elevation of the same magnitude through exercise (450 kpm/min for 40 min) induced no change in Prl secretion. It is concluded that increase in core temperature is a stimulus of Prl secretion and suggested that exercise apparently inhibits the stimulatory effect.


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