Estradiol administration suppresses body temperature elevation induced by application of menthol to ovariectomized rats

2018 ◽  
Vol 78 ◽  
pp. 281-289 ◽  
Author(s):  
Yuki Uchida ◽  
Koyuki Atsumi ◽  
Shinji Hirano ◽  
Nao Koyanagi
Keyword(s):  
Body Temperature ◽  
Ovariectomized Rats ◽  
Temperature Elevation

A Pharmacologic Study on the Mechanism of Action of Kakkon-to: Body Temperature Elevation and Phagocytic Activation of Macrophages in Dogs

2004 ◽  
Vol 10 (5) ◽  
pp. 841-849 ◽  
Author(s):  
Kenichi Muraoka ◽  
Satoshi Yoshida ◽  
Kazumasa Hasegawa ◽  
Nobuo Nakanishi ◽  
Isao Fukuzawa ◽  
...  
Keyword(s):  
Body Temperature ◽  
Mechanism Of Action ◽  
Temperature Elevation ◽  
Pharmacologic Study

A Pharmacologic Study on the Mechanism of Action of Kakkon-to : Body Temperature Elevation and Phagocytic Activation of Macrophages in Dogs

2004 ◽  
Vol 10 (5) ◽  
pp. 841-849
Author(s):  
Kenichi Muraoka ◽  
Satoshi Yoshida ◽  
Kazumasa Hasegawa ◽  
Nobuo Nakanishi ◽  
Isao Fukuzawa ◽  
...  
Keyword(s):  
Body Temperature ◽  
Mechanism Of Action ◽  
Temperature Elevation ◽  
Pharmacologic Study

scholarly journals Sasa Quelpaertensis Nakai Induced Antidepressant-Like Effect in Ovariectomized Rats

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Noof Abdullah Shaif ◽  
Donghyun Cho ◽  
Daehyuk Jang ◽  
Hyung Min Kim ◽  
Jin-Oh Chung ◽  
...  
Keyword(s):  
Body Temperature ◽  
Tryptophan Hydroxylase ◽  
Forced Swim Test ◽  
Ovariectomized Rats ◽  
Enzyme Linked Immunosorbent Assay ◽  
Dwarf Bamboo ◽  
Hypothalamic Region ◽  
Repeated Stress ◽  
Cell Counts ◽  
Immobility Time

Background. Sasa quelpaertensis Nakai extract (SQE) or dwarf bamboo has been extensively investigated for its antioxidant and anti-inflammatory effects; however, no previous study assessed its effect as an antidepressant agent. Therefore, this study was designed to examine the effect of oral SQE administration in ameliorating menopausal depressive symptoms and to evaluate its mechanisms in ovariectomized rats with repeated stress. Methods. All experimental groups except normal group underwent ovariectomy and then immobilization for 14 consecutive days. During these 2 weeks, two rat groups received SQE (100 and 300 mg/kg orally) and their cutaneous body temperature was measured. The tail suspension test (TST) and forced swim test (FST) were performed in order to evaluate depression-like behavior. Additionally, enzyme-linked immunosorbent assay (ELISA) and immunohistochemistry were carried out to evaluate the central monoaminergic neurotransmitter levels and activity. Results. Oral SQE (100 mg/kg) administration had reduced immobility time in TST and FST. Additionally, the SQE 100 and 300 mg/kg administration had decreased the cutaneous body temperature in the rats compared to those without treatment. In ELISA analysis, the SQE 100 group expressed elevated levels of serotonin and dopamine in the hypothalamus, prefrontal cortex, and hippocampus. Antityrosine hydroxylase (anti-TH) antibodies showed a tremendous increase in the density of TH positive cells in the locus coeruleus (LC) region of the SQE 100 group. Likewise, the SQE 100 elevated the number of tryptophan hydroxylase (TPH) and protein kinase C (PKC) immunoreactive cell counts and density in the hypothalamic region. Conclusion. These results suggested that the oral SQE administration induced the antidepressant-like effect in the ovariectomized rats with repeated stress via upregulating the levels of serotonin and dopamine through enhancing the expression of TH, TPH, and PKC in many brain areas.

Review of Recent Evidence of Toxic Effects of Hexachlorophene

PEDIATRICS ◽  
1973 ◽  
Vol 51 (2) ◽  
pp. 391-394
Author(s):  
Renate D. Kimbrough
Keyword(s):  
White Matter ◽  
Body Temperature ◽  
Oxidative Phosphorylation ◽  
Gray Matter ◽  
Microscopic Examination ◽  
Published Data ◽  
Temperature Elevation ◽  
Status Spongiosus ◽  
Repeated Doses ◽  
Neurological Effects

The published data on the toxicity of hexachlorophene in animals and man are discussed. Studies performed in the author's laboratory including hexachlorophene blood level determinations in animals and man are also reviewed. Hexachlorophene can produce paralysis in rats, rabbits, cats, and pigs and blindness in sheep. Microscopic examination of the brains of rats and monkeys given repeated doses of hexachlorophene shows status spongiosus of the white matter and normal gray matter. Small amounts of hexachlorophene are absorbed through the skin of animals as well as man. Aside from the neurological effects of hexachlorophene, the chemical uncouples oxidative phosphorylation which may cause body temperature elevation.

Role of prostaglandins in exercise-induced core temperature elevation in female Sprague-Dawley rats

1993 ◽  
Vol 265 (5) ◽  
pp. R1121-R1125
Author(s):  
P. J. Rowsey ◽  
K. T. Borer ◽  
M. J. Kluger
Keyword(s):  
Body Temperature ◽  
Sodium Salicylate ◽  
Voluntary Exercise ◽  
Female Rats ◽  
Temperature Elevation ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Exercise Induced ◽  
Running Wheels

Female Sprague-Dawley rats (12:12-h photoperiod; body temperature, BT, measured with biotelemetry) with access to running wheels for 6 wk have an elevated BT (compared with rats with no access to exercise wheels, i.e, sedentary) both during the period of voluntary exercise (nighttime) (0.5 degree C, P = 0.0001) and the nonexercise period (daytime) (0.3 degree C, P = 0.002). To determine whether prostaglandin (PG) E was responsible for any portion of this daytime rise in BT, we injected a dose of sodium salicylate (300 mg/kg), which was shown to produce complete antipyresis in rats injected with lipopolysaccharide (LPS), into exercised and sedentary rats 4 h after the onset of the lights-on period. The injections of sodium salicylate led to a fall in body temperature in both the exercised and sedentary rats of similar amounts (-0.88 degree C vs. -0.61 degree C at 2 h postinjection, P = 0.59). We conclude that the increase in daytime BT of exercised female rats is not mediated by prostaglandins.

Body temperature elevation, exercise and serum prolactin concentrations

1985 ◽  
Vol 109 (4) ◽  
pp. 458-462 ◽  
Author(s):  
Stig Engkjær Christensen ◽  
Otto Jørgensen ◽  
Jan Møller ◽  
Niels Møller ◽  
Hans Ørskov
Keyword(s):  
Body Temperature ◽  
Normal Weight ◽  
Tympanic Temperature ◽  
Serum Prolactin ◽  
Pituitary Hormone ◽  
Relative Role ◽  
Hormone Release ◽  
Temperature Elevation ◽  
Body Temperature Increase

Abstract. Ten young healthy normal-weight males were studied in four test situations designed to elucidate the relative role of body temperature increase vs that of exercise per se for pituitary hormone release. Tympanic temperature was recorded continuously during the tests. Elevation of body temperature at rest induced by external heating resulted in parallel changes in serum prolactin (Prl), also found when temperature spontaneously returned towards normal. In contrast, temperature elevation of the same magnitude through exercise (450 kpm/min for 40 min) induced no change in Prl secretion. It is concluded that increase in core temperature is a stimulus of Prl secretion and suggested that exercise apparently inhibits the stimulatory effect.

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