Acupuncture as a Treatment Modality in Dermatology: A Systematic Review

Research on the use of surface electromyography (sEMG) for analyzing the effects of Manual Therapy (MT) seems to have very dispersed intentions. The development of data collection protocols using sEMG might not be stable for conducting clinical studies. This study aimed to evaluate the current literature using surface sEMG in the context of MT and verify if it is a useful tool to verify its effectiveness. Also, to assess the methodologic quality and reporting standards and make a reflective analysis of how this technique has been used for this treatment modality. A computerized search was performed in May 2017 and repeated in June 2018, the search was performed in 8 electronic databases following PRISMA protocol. Thirty-one papers were included. More and better-designed studies are needed to create improved protocols. Further exploration and validation of these protocols may help to conduct more reliable clinically driven trials and it may inform policymakers of the role of MT in health care. The detection of clinically meaningful electrical alterations in muscles seems to be the main objective of most authors. Several sEMG items were not reported, and overall methodology quality was low.

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Treatment modalities of necrobiosis lipoidica: a concise systematic review

Dermatology Reports ◽

10.4081/dr.2015.5749 ◽

2015 ◽

Vol 7 (2) ◽

Cited By ~ 8

Author(s):

Amir Feily ◽

Shadi Mehraban

Keyword(s):

Diabetes Mellitus ◽

Systematic Review ◽

Clinical Trials ◽

Treatment Modality ◽

Skin Disorder ◽

Case Reports ◽

Google Scholar ◽

Treatment Modalities ◽

Small Scale ◽

Necrobiosis Lipoidica

Necrobiosis lipoidica (NL) is a rare inflammatory granulomatous skin disorder closely associated with diabetes mellitus. The aim of this paper is to review and discuss all the treatment modalities proposed and tested for this disease. A systematic review of the existing literature was conducted to investigate all the available data and summarize all the clinical trials, case reports and original articles on NL. Two major databases (PubMed and Google Scholar) were used. We have examined about 70 articles. Numerous treatment modalities have been currently investigated to compare recalcitrant NL. Being rare, most of the studies regarding this disease are case reports or small-scale clinical trials. We have found that, in spite of plentiful investigations carried out during the years, there is no treatment modality that has proved to be utterly satisfactory in treating NL.

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Endovascular Super-Selective Intra-Arterial Chemotherapy for Retinoblastoma: Systematic Review and Institutional Experience

Neurosurgery ◽

10.1093/neuros/nyz310_454 ◽

2019 ◽

Vol 66 (Supplement_1) ◽

Author(s):

Simon Menaker ◽

Samir Sur ◽

Anil Mahavadi ◽

Stephanie H Chen ◽

Eric C Peterson ◽

...

Keyword(s):

Systematic Review ◽

Treatment Modality ◽

Tumor Staging ◽

Neurological Complication ◽

Tumor Grade ◽

Complication Rates ◽

Transient Phenomena ◽

Pertinent Data ◽

Institutional Experience ◽

Salvage Rate

Abstract INTRODUCTION Selective intra-arterial delivery of chemotherapy (IAC) via microcatheter infusion into the ophthalmic artery has become an increasingly popular treatment modality to accomplish globe salvage in children with retinoblastoma. While previously limited to highly specialized centers, interest in and popularity of this treatment are growing. Here, we provide a comprehensive review of available data in addition to our own experience. METHODS Systematic literature review was conducted using PRISMA guidelines and 22 studies were identified that met inclusion criteria. In our own series, consecutive patients undergoing IAC for retinoblastoma were identified between January 2009 and December 2016. Pertinent data, including tumor grade, enucleation vs globe salvage, and both ocular and systemic adverse events were recorded. RESULTS In all1593 total eyes were treated as reported in 22 studies published between 2011 and 2019. Among those in which tumor staging data was available, 396 (27.6%) were less advanced (Reese–Ellsworth A-C, or International Classification I-III) and 997 (69.4%) were more advanced (D-E, IV-V). A total of 21 studies included data on systemic and/or ocular complications, which with few exceptions were transient and resulted in no permanent morbidity. A single permanent neurological complication occurred. Analysis of our institutional experience demonstrated a globe salvage rate of 73% (identical to pooled data from the literature). In 442 procedures, our ocular and systemic complication rates were 10.6% and 13.8%, respectively; virtually all were transient phenomena including orbital edema, myelosuppression, and and brief intraprocedural bronchospasm/bradycardia during drug delivery. CONCLUSION Although reported predominantly in retrospective series, a systematic review of outcomes in selective IAC for retinoblastoma demonstrates efficacy (73% globe salvage rate) with minimal morbidity, even in advanced disease. Our own results reflect a similar experience and taken together, provide strong evidence that this treatment modality is safe and effective. The data support adoption of this technique as first-line therapy for globe salvage in selected cases of retinoblastoma.

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Resolvins as a Treatment Modality in Experimental Periodontitis: A Systematic Review of Preclinical Studies

Cureus ◽

10.7759/cureus.21095 ◽

2022 ◽

Author(s):

Nouf Alshibani

Keyword(s):

Systematic Review ◽

Treatment Modality ◽

Preclinical Studies ◽

Experimental Periodontitis

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Repeat Gamma Knife radiosurgery versus microvascular decompression following failure of GKRS in trigeminal neuralgia: a systematic review and meta-analysis

Journal of Neurosurgery ◽

10.3171/2018.5.jns18583 ◽

2019 ◽

Vol 131 (4) ◽

pp. 1197-1206 ◽

Cited By ~ 2

Author(s):

Devi Prasad Patra ◽

Amey Rajan Savardekar ◽

Rimal Hanif Dossani ◽

Vinayak Narayan ◽

Nasser Mohammed ◽

...

Keyword(s):

Systematic Review ◽

Pain Relief ◽

Trigeminal Neuralgia ◽

Microvascular Decompression ◽

Treatment Modality ◽

Meta Analysis ◽

Gamma Knife Radiosurgery ◽

Facial Numbness ◽

Retreatment Rate ◽

Secondary Outcomes

OBJECTIVEGamma Knife radiosurgery (GKRS) has emerged as a promising treatment modality for patients with classical trigeminal neuralgia (TN); however, considering that almost half of the patients experience post-GKRS failure or lesion recurrence, a repeat treatment is typically necessary. The existing literature does not offer clear evidence to establish which treatment modality, repeat GKRS or microvascular decompression (MVD), is superior. The present study aimed to compare the overall outcome of patients who have undergone either repeat GKRS or MVD after failure of their primary GKRS; the authors do so by conducting a systematic review and meta-analysis of the literature and analysis of data from their own institution.METHODSThe authors conducted a systematic review and meta-analysis of the PubMed, Cochrane Library, Web of Science, and CINAHL databases to identify studies describing patients who underwent either repeat GKRS or MVD after initial failed GKRS for TN. The primary outcomes were complete pain relief (CPR) and adequate pain relief (APR) at 1 year. The secondary outcomes were rate of postoperative facial numbness and the retreatment rate. The pooled data were analyzed with R software. Bias and heterogeneity were assessed using funnel plots and I2 tests, respectively. A retrospective analysis of a series of patients treated by the authors who underwent repeat GKRS or MVD after post-GKRS failure or relapse is presented.RESULTSA total of 22 studies met the selection criteria and were included for final data retrieval and meta-analysis. The search did not identify any study that had directly compared outcomes between patients who had undergone repeat GKRS versus those who had undergone MVD. Therefore, the authors’ final analysis included two groups: studies describing outcome after repeat GKRS (n = 17) and studies describing outcome after MVD (n = 5). The authors’ institutional study was the only study with direct comparison of the two cohorts. The pooled estimates of primary outcomes were APR in 83% of patients who underwent repeat GKRS and 88% of those who underwent MVD (p = 0.49), and CPR in 46% of patients who underwent repeat GKRS and 72% of those who underwent MVD (p = 0.02). The pooled estimates of secondary outcomes were facial numbness in 32% of patients who underwent repeat GKRS and 22% of those who underwent MVD (p = 0.11); the retreatment rate was 19% in patients who underwent repeat GKRS and 13% in those who underwent MVD (p = 0.74). The authors’ institutional study included 42 patients (repeat GKRS in 15 and MVD in 27), and the outcomes 1 year after retreatment were APR in 80% of those who underwent repeat GKRS and 81% in those who underwent MVD (p = 1.0); CPR was achieved in 47% of those who underwent repeat GKRS and 44% in those who underwent MVD (p = 1.0). There was no difference in the rate of postoperative facial numbness or retreatment.CONCLUSIONSThe current meta-analysis failed to identify any superiority of one treatment over the other with comparable outcomes in terms of APR, postoperative facial numbness, and retreatment rates. However, MVD was shown to provide a better chance of CPR compared with repeat GKRS.

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