p53 Gene Expression and 2-Methoxyestradiol Treatment Differentially Induce Nuclear Factor Kappa B Activation in Human Lung Cancer Cells with Different p53 Phenotypes

2009 ◽  
Vol 28 (12) ◽  
pp. 615-623 ◽  
Author(s):  
Pramod C. Rath ◽  
Tapas Mukhopadhyay
Keyword(s):  
Gene Expression ◽  
Lung Cancer ◽  
Cancer Cells ◽  
Nuclear Factor Kappa B ◽  
Human Lung ◽  
P53 Gene ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Nuclear Factor ◽  
Human Lung Cancer Cells

scholarly journals The Marine Dinoflagellate Alexandrium minutum Activates a Mitophagic Pathway in Human Lung Cancer Cells

Marine Drugs ◽  
2018 ◽  
Vol 16 (12) ◽  
pp. 502 ◽  
Author(s):  
Christian Galasso ◽  
Genoveffa Nuzzo ◽  
Christophe Brunet ◽  
Adrianna Ianora ◽  
Angela Sardo ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lung Cancer ◽  
Cancer Cells ◽  
Human Lung ◽  
Water Soluble ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Normal Lung ◽  
Alexandrium Minutum ◽  
Human Lung Cancer Cells

Marine dinoflagellates are a valuable source of bioactive molecules. Many species produce cytotoxic compounds and some of these compounds have also been investigated for their anticancer potential. Here, we report the first investigation of the toxic dinoflagellate Alexandrium minutum as source of water-soluble compounds with antiproliferative activity against human lung cancer cells. A multi-step enrichment of the phenol–water extract yielded a bioactive fraction with specific antiproliferative effect (IC50 = 0.4 µg·mL−1) against the human lung adenocarcinoma cells (A549 cell line). Preliminary characterization of this material suggested the presence of glycoprotein with molecular weight above 20 kDa. Interestingly, this fraction did not exhibit any cytotoxicity against human normal lung fibroblasts (WI38). Differential gene expression analysis in A549 cancer cells suggested that the active fraction induces specific cell death, triggered by mitochondrial autophagy (mitophagy). In agreement with the cell viability results, gene expression data also showed that no mitophagic event was activated in normal cells WI38.

scholarly journals Alteration of drug chemosensitivity caused by the adenovirus-mediated transfer of the wild-type p53 gene in human lung cancer cells

2000 ◽  
Vol 7 (2) ◽  
pp. 300-307 ◽  
Author(s):  
Shin-ichi Osaki ◽  
Yoichi Nakanishi ◽  
Koichi Takayama ◽  
Xin-Hai Pei ◽  
Hikaru Ueno ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Human Lung ◽  
P53 Gene ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Wild Type ◽  
Human Lung Cancer Cells ◽  
Wild Type P53

scholarly journals Effect of Pro-Inflammatory Cytokine IL-1β, on Urotensin II Gene Expression in Human Lung Cancer Cells

2018 ◽  
pp. 354-359
Author(s):  
HAMZA MALİK OKUYAN ◽  
MENDERES YUSUF TERZİ ◽  
CANSU ÖNLEN GÜNERİ ◽  
MERAL URHAN KÜÇÜK
Keyword(s):  
Gene Expression ◽  
Lung Cancer ◽  
Cancer Cells ◽  
Inflammatory Cytokine ◽  
Human Lung ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Urotensin Ii ◽  
Human Lung Cancer Cells
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