scholarly journals Red Ginseng Root Extract Mixed with Torilus Fructus and Corni Fructus Improves Facial Wrinkles and Increases Type I Procollagen Synthesis in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study

2009 ◽  
Vol 12 (6) ◽  
pp. 1252-1259 ◽  
Author(s):  
Soyun Cho ◽  
Chong-Hyun Won ◽  
Dong Hun Lee ◽  
Min-Jung Lee ◽  
Serah Lee ◽  
...  
Keyword(s):  
Human Skin ◽  
Ginseng Root ◽  
Controlled Study ◽  
Root Extract ◽  
Type I ◽  
Red Ginseng ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Type I Procollagen ◽  
Corni Fructus

scholarly journals Oral Intake of Hydrangea serrata (Thunb.) Ser. Leaves Extract Improves Wrinkles, Hydration, Elasticity, Texture, and Roughness in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1588
Author(s):  
Da-Bin Myung ◽  
Jeong-Hun Lee ◽  
Hee-Soo Han ◽  
Kwang-Young Lee ◽  
Hye Shin Ahn ◽  
...  
Keyword(s):  
Human Skin ◽  
Elastic Recovery ◽  
Controlled Trial ◽  
Water Extract ◽  
Hot Water ◽  
Controlled Study ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Skin Wrinkles

Previously, we reported that the hot water extract of Hydrangea serrata leaves (WHS) and its active component, hydrangenol, possess in vitro and in vivo effects on skin wrinkles and moisturization. We conducted a randomized, double-blind, placebo-controlled trial to clinically evaluate the effect of WHS on human skin. Participants (n = 151) were randomly assigned to receive either WHS 300 mg, WHS 600 mg, or placebo, once daily for 12 weeks. Skin wrinkle, hydration, elasticity, texture, and roughness parameters were assessed at baseline and after 4, 8, and 12 weeks. Compared to the placebo, skin wrinkles were significantly reduced in both WHS groups after 8 and 12 weeks. In both WHS groups, five parameters (R1–R5) of skin wrinkles significantly improved and skin hydration was significantly enhanced when compared to the placebo group after 12 weeks. Compared with the placebo, three parameters of skin elasticity, including overall elasticity (R2), net elasticity (R5), and ratio of elastic recovery to total deformation (R7), improved after 12 weeks of oral WHS (600 mg) administration. Changes in skin texture and roughness were significantly reduced in both WHS groups. No WHS-related adverse reactions were reported. Hence, WHS could be used as a health supplement for skin anti-aging.

scholarly journals Therapeutic Effects of Fermented Red Ginseng in Allergic Rhinitis: A Randomized, Double-Blind, Placebo-Controlled Study

2011 ◽  
Vol 3 (2) ◽  
pp. 103 ◽  
Author(s):  
Jae-Woo Jung ◽  
Hye-Ryun Kang ◽  
Geun-Eog Ji ◽  
Myeong-Soo Park ◽  
Woo-Jung Song ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Controlled Study ◽  
Therapeutic Effects ◽  
Red Ginseng ◽  
Double Blind ◽  
Double Blind Placebo

scholarly journals Effect of GutGard in the Management ofHelicobacter pylori: A Randomized Double Blind Placebo Controlled Study

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Sreenivasulu Puram ◽  
Hyung Chae Suh ◽  
Seung Un Kim ◽  
Bharathi Bethapudi ◽  
Joshua Allan Joseph ◽  
...  
Keyword(s):  
Repeated Measures ◽  
Treated Group ◽  
Controlled Study ◽  
Root Extract ◽  
Double Blind ◽  
Exact Probability ◽  
Double Blind Placebo ◽  
Significant Difference ◽  
The Difference ◽  
H Pylori

A randomized, double blind placebo controlled study was conducted to evaluate the efficacy of GutGard (root extract ofGlycyrrhiza glabra) in the management ofHelicobacter pylori(H. pylori) gastric load. Participants diagnosed withH. pyloriinfection were randomly assigned to two groups to orally receive 150 mg of GutGard (n=55) or placebo (n=52) once daily for 60 days.H. pyloriinfection was assessed using13C-urea breath test (13C-UBT) at days 0, 30, and 60. Stool Antigen test (HpSA) was also performed on days 0, 30, and 60. Repeated measures of analysis of variance (RMANOVA), chi-square, and Fisher's exact probability tests were used to compare the treatment outcomes. A significant interaction effect between group and time (P=0.00) and significant difference in mean Delta Over Baseline (DOB) values between GutGard (n=50) and placebo (n=50) treated groups after intervention period were observed. On day 60, the results of HpSA test were negative in 28 subjects (56%) in GutGard treated group whereas in placebo treated group only 2 subjects (4%) showed negative response; the difference between the groups was statistically significant. On day 60, the results of13C-UBT were negative in 24 (48%) in GutGard treated group and the difference between the groups was statistically significant. The findings suggest GutGard is effective in the management ofH. pylori.

scholarly journals Treatment of complex regional pain syndrome type I with neridronate: a randomized, double-blind, placebo-controlled study

Rheumatology ◽  
2012 ◽  
Vol 52 (3) ◽  
pp. 534-542 ◽  
Author(s):  
M. Varenna ◽  
S. Adami ◽  
M. Rossini ◽  
D. Gatti ◽  
L. Idolazzi ◽  
...  
Keyword(s):  
Complex Regional Pain Syndrome ◽  
Pain Syndrome ◽  
Controlled Study ◽  
Type I ◽  
Syndrome Type ◽  
Double Blind ◽  
Double Blind Placebo
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