Identification of Remaining Life Expectancy Less Than Two Weeks by C-Reactive Protein/Albumin Ratio, Prognostic Nutritional Index, Fibrosis-4 Index, and Albumin-Bilirubin Score in Terminal Cancer Patients

2021 ◽  
Author(s):  
Shoko Ieda ◽  
Tomoyoshi Miyamoto ◽  
Kouichi Hosomi ◽  
Manabu Takegami ◽  
Atsufumi Kawabata
Keyword(s):  
Life Expectancy ◽  
Prognostic Nutritional Index ◽  
Terminal Cancer ◽  
Remaining Life ◽  
C Reactive Protein ◽  
Albumin Ratio ◽  
Reactive Protein ◽  
Nutritional Index ◽  
Terminal Cancer Patients ◽  
Remaining Life Expectancy

scholarly journals Prognostic Nutritional Index After Chemoradiotherapy Was the Strongest Prognostic Predictor Among Biological and Conditional Factors in Localized Pancreatic Ductal Adenocarcinoma Patients

Cancers ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 514 ◽  
Author(s):  
Ichikawa ◽  
Mizuno ◽  
Hayasaki ◽  
Kishiwada ◽  
Fujii ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Prognostic Score ◽  
Glasgow Prognostic Score ◽  
Prognostic Nutritional Index ◽  
Ductal Adenocarcinoma ◽  
C Reactive Protein ◽  
Albumin Ratio ◽  
Reactive Protein ◽  
Nutritional Index

Background: In many malignancies, including pancreatic ductal adenocarcinoma (PDAC), host-related inflammatory/immunonutritional markers, such as the prognostic nutritional index (PNI), modified Glasgow prognostic score (mGPS), and C-reactive protein (CRP)/albumin ratio are reported to be prognostic factors. However, the prognostic influence of these factors before and after chemoradiotherapy (CRT) has not been studied in PDAC patients. Methods: Of 261 consecutive PDAC patients who were scheduled for CRT with gemcitabine or S1 plus gemcitabine between February 2005 and December 2015, participants in this study were 176 who completed CRT and had full data available on inflammatory/immunonutritional markers as well as on anatomical and biological factors for the investigation of prognostic/predictive factors. Results: In multivariate analysis, the significant prognostic factors were RECIST classification, cT category, performance status, post-CRT carcinoembryonic antigen, post-CRT C-reactive protein/albumin ratio, post-CRT mGPS, and post-CRT PNI. Post-CRT PNI (cut-off value, 39) was the strongest host-related prognostic factor according to the p-value. In the patients who underwent resection after CRT, median survival time (MST) was significantly shorter in the 12 patients with low PNI (<39) than in the 97 with high PNI (≥39), at 15.5 months versus 27.2 months, respectively (p = 0.0016). In the patients who did not undergo resection, MST was only 8.9 months in those with low PNI and 12.3 months in those with high PNI (p < 0.0001), and thus was similar to that of the resected patients with low PNI. Conclusions: Post-CRT PNI was the strongest prognostic/predictive indicator among the independent biological and conditional prognostic factors in PDAC patients who underwent CRT.

scholarly journals Novel Systemic Inflammation Markers to Predict COVID-19 Prognosis

2021 ◽  
Vol 12 ◽  
Author(s):  
Amirali Karimi ◽  
Parnian Shobeiri ◽  
Arutha Kulasinghe ◽  
Nima Rezaei
Keyword(s):  
Inflammatory Response ◽  
Patient Outcomes ◽  
Severe Disease ◽  
Prognostic Nutritional Index ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Albumin Ratio ◽  
Reactive Protein ◽  
Nutritional Index ◽  
Global Pandemic

Coronavirus disease 2019 (COVID-19) has resulted in a global pandemic, challenging both the medical and scientific community for the development of novel vaccines and a greater understanding of the effects of the SARS-CoV-2 virus. COVID-19 has been associated with a pronounced and out-of-control inflammatory response. Studies have sought to understand the effects of inflammatory response markers to prognosticate the disease. Herein, we aimed to review the evidence of 11 groups of systemic inflammatory markers for risk-stratifying patients and prognosticating outcomes related to COVID-19. Numerous studies have demonstrated the effectiveness of neutrophil to lymphocyte ratio (NLR) in prognosticating patient outcomes, including but not limited to severe disease, hospitalization, intensive care unit (ICU) admission, intubation, and death. A few markers outperformed NLR in predicting outcomes, including 1) systemic immune-inflammation index (SII), 2) prognostic nutritional index (PNI), 3) C-reactive protein (CRP) to albumin ratio (CAR) and high-sensitivity CAR (hsCAR), and 4) CRP to prealbumin ratio (CPAR) and high-sensitivity CPAR (hsCPAR). However, there are a limited number of studies comparing NLR with these markers, and such conclusions require larger validation studies. Overall, the evidence suggests that most of the studied markers are able to predict COVID-19 prognosis, however NLR seems to be the most robust marker.

scholarly journals Correlation of Operative Mortality and Morbidity With Preoperative C-Reactive Protein/Albumin Ratio, Neutrophil/Lymphocyte Ratio, and Prognostic Nutritional Index in Patients Undergoing Emergent Operations Due to Strangulation Ileus

2021 ◽  
Vol 105 (1-3) ◽  
pp. 278-283
Author(s):  
Masahide Ikeguchi ◽  
Takehiko Hanaki ◽  
Kyo-ichi Kihara ◽  
Kanenori Endo ◽  
Kazunori Suzuki ◽  
...  
Keyword(s):  
Postoperative Complications ◽  
Prognostic Nutritional Index ◽  
C Reactive Protein ◽  
Albumin Ratio ◽  
Mortality And Morbidity ◽  
Neutrophil Lymphocyte Ratio ◽  
Reactive Protein ◽  
Nutritional Index ◽  
Strangulation Ileus ◽  
Emergent Surgery

Emergent surgery is necessary in patients with strangulation ileus. However, such procedures are associated with high morbidity and mortality. A retrospective analysis was performed to determine whether the preoperative C-reactive protein/albumin ratio (CAR); neutrophil/lymphocyte ratio (NLR); and prognostic nutritional index (PNI) are good indicators of mortality or morbidity in patients undergoing emergent operations for treatment of strangulation ileus. Emergent surgery was performed for 1698 patients at Tottori Prefectural Central Hospital from 2012 and 2015. Among them, 45 patients (2.7%) were preoperatively diagnosed with strangulation ileus. We evaluated the clinical importance of the preoperative CAR, NLR, and PNI in these patients. We excluded pediatric patients from this study. Postoperative complications developed in 14 of 45 (31.1%) patients. The mean postoperative hospital stay among the 14 patients with postoperative complications was significantly longer than that of the 31 patients without postoperative complications (44.0 versus 11.3 days, respectively; P = 0.006). Three patients died of postoperative complications. The overall operative mortality and morbidity rates were 6.7% and 31.1%, respectively. We found strong correlations of postoperative complications with older age, a longer operation time, and an abnormal preoperative CAR, NLR, and PNI. Not only inflammation, but also a patients' nutritional and immune status appear to be strongly correlated with mortality or morbidity after emergent operations for strangulation ileus. Patients with a high CAR and NLR and low PNI preoperatively must be closely monitored for the occurrence of postoperative complications such as surgical site infections or pulmonary complications.

scholarly journals Impact of prognostic nutritional index on terminal cancer patients

2020 ◽  
Vol 26 (4) ◽  
pp. 433
Author(s):  
AmrallahA Mohammed ◽  
Omar Al-Zahrani ◽  
FifiMostafa Elsayed
Keyword(s):  
Cancer Patients ◽  
Prognostic Nutritional Index ◽  
Terminal Cancer ◽  
Nutritional Index ◽  
Terminal Cancer Patients

scholarly journals Changes in Inflammatory Biomarkers Related to C-reactive Protein and Albumin in Patients With Terminal Cancer Receiving Palliative Care: a Longitudinal Study

2021 ◽  
Author(s):  
EMANUELLY VAREA MARIA WIEGERT ◽  
LARISSA CALIXTO-LIMA ◽  
GABRIELLA DA COSTA CUNHA ◽  
Tais Saint Martin Fonseca ◽  
GEISIANE ALVES DA SILVA ◽  
...  
Keyword(s):  
Palliative Care ◽  
Inflammatory Biomarkers ◽  
Longitudinal Change ◽  
Terminal Cancer ◽  
C Reactive Protein ◽  
Albumin Ratio ◽  
Reactive Protein ◽  
Time Period ◽  
Cancer Trajectory ◽  
End Stage

Abstract Background: Evidence about how inflammatory biomarkers vary during the end-stage cancer trajectory is lacking. This study investigates the longitudinal changes in albumin and C-reactive protein (CRP) levels, and CRP/albumin ratio (CAR) in patients with terminal cancer receiving palliative care in the last three months of life.Methods: This is a retrospective analysis of variables extracted from a prospective cohort study that included admitted patients to the exclusive Palliative Care Unit of the National Cancer Institute in Brazil. Routine blood examination results of albumin and CRP were recorded at 0-15 (T1), 16-30 (T2), 31-45 (T3), 46-60 (T4), 61-75 (T5), and 76-90 (T6) days before death and only patients with at least two measurements were included. Crude and adjusted linear mixed-effects regression models were performed to verify the relationships between the longitudinal trajectories of biomarkers and death. Results: A total of 1,635 patients were included. Median albumin was 3.00g/dL across the whole time-period analyzed (interquartile range, IQR: 2.50-3.60) and decreased with the approach of death, while median CRP was 9.31mg/L (IQR: 4.42-17.30) and CAR was 3.20 (IQR: 1.40-6.60), and both increased. The albumin (slope: 0.01 to 0.02; p <0.001), CRP (slope: -0.10 to -0.12; p <0.001), and CAR (slope: -0.06; p <0.001) showed a linear dose-response relationship with death in crude and adjusted models tested. Conclusions: The longitudinal change levels of inflammatory biomarkers worsen with the approach of death and could be used to predict end-stage in patients with terminal cancer.

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