scholarly journals Prognostic value of the c-reactive protein/prognostic nutritional index ratio after hip fracture surgery in the elderly population

Oncotarget ◽  
2017 ◽  
Vol 8 (37) ◽  
pp. 61365-61372 ◽  
Author(s):  
Hanru Ren ◽  
Lianghao Wu ◽  
Wankun Hu ◽  
Xiuzhang Ye ◽  
Baoqing Yu
Keyword(s):  
Elderly Population ◽  
Prognostic Nutritional Index ◽  
The Elderly ◽  
C Reactive Protein ◽  
Hip Fracture Surgery ◽  
Reactive Protein ◽  
Nutritional Index ◽  
Surgery In The Elderly ◽  
Index Ratio ◽  
Fracture Surgery

scholarly journals Predictors of Acute Kidney Injury After Hip Fracture in Older Adults

2020 ◽  
Vol 11 ◽  
pp. 215145932092008 ◽  
Author(s):  
Julie Braüner Christensen ◽  
Martin Aasbrenn ◽  
Luana Sandoval Castillo ◽  
Anette Ekmann ◽  
Thomas Giver Jensen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acute Kidney Injury ◽  
Hip Fracture ◽  
Blood Transfusion ◽  
Multivariable Analysis ◽  
Kidney Injury ◽  
C Reactive Protein ◽  
Hip Fracture Surgery ◽  
Reactive Protein ◽  
Fracture Surgery

Introduction: This study aimed to investigate the prevalence of acute kidney injury (AKI) following hip fracture surgery in geriatric patients and to identify predictors for development of AKI with a focus on possible preventable risk factors. Methods: In this retrospective cohort study, we reviewed electronic medical records of all patients above 65 years of age who underwent hip fracture surgery at Copenhagen University Hospital, Bispebjerg, Denmark, in 2018. Acute kidney injury was assessed according to the Kidney Disease Improving Global Outcomes guidelines. Multivariate logistic regression analyses were used to identify independent risk factors for AKI. Results: Postoperative AKI developed in 28.4% of the included patients (85/299). Acute kidney injury was associated with increased length of admission (11.3 vs 8.7 days, P < .001) and 30-day mortality (18/85 vs 16/214, P = .001). In multivariable analysis, higher age (odds ratio [OR]: 1.05, 95% confidence interval [CI]: 1.01-1.08, P = .004), heart disease (OR: 1.78, 95% CI: 1.01-3.11, P = .045), and postoperative blood transfusion (OR: 1.84, 95% CI: 1.01-3.36, P = .048) were associated with AKI. Moreover, a higher postoperative C-reactive protein (199.0 ± 99.9 in patients with AKI, 161.3 ± 75.2 in patients without AKI) and lower postoperative diastolic blood pressure were observed in patients developing AKI. Discussion and Conclusion: Acute kidney injury was common following hip fracture surgery and associated with longer admissions and increased mortality. Patients developing AKI were older and showed several postoperative similarities, including higher C-reactive protein, lower postoperative diastolic pressure, and the need for blood transfusion.

scholarly journals C-reactive protein is an independent predictor for 1-year mortality in elderly patients undergoing hip fracture surgery

Medicine ◽  
2016 ◽  
Vol 95 (43) ◽  
pp. e5152 ◽  
Author(s):  
Byung-Gun Kim ◽  
Young-Kyun Lee ◽  
Hee-Pyoung Park ◽  
Hye-Min Sohn ◽  
Ah-Young Oh ◽  
...  
Keyword(s):  
Hip Fracture ◽  
Elderly Patients ◽  
Independent Predictor ◽  
C Reactive Protein ◽  
Hip Fracture Surgery ◽  
Reactive Protein ◽  
Fracture Surgery

scholarly journals Lipid Management in the Elderly Population

2021 ◽  
Vol 3 (1) ◽  
pp. 60-63
Author(s):  
Micheli Ito Gimenes Pires ◽  
Thaise de Araujo Wrubleski ◽  
Gustavo Lenci Marques
Keyword(s):  
Elderly Population ◽  
Cholesterol Absorption ◽  
The Elderly ◽  
Population Ageing ◽  
Blood Levels ◽  
C Reactive Protein ◽  
First Line ◽  
Intestinal Cholesterol Absorption ◽  
Lipid Management ◽  
Reactive Protein

Considering that deaths from cardiovascular disease have been increasing in proportion to population ageing, prevention and treatment of dyslipidemia in elderly people is essential to avoid such outcome. Some biomarkers, albeit with limitations, have shown effectiveness in predicting cardiovascular events. Among them, blood levels of C-reactive protein, Lipoprotein A and, especially, coronary artery calcium. Dyslipidemia management primarily includes changes in lifestyle, such as physical activity, diet and smoking cessation. However, in elderly, drug therapy may be necessary, with statins being the first line treatment. In addition, therapies with drugs that decrease intestinal cholesterol absorption or increase LDL absorption by the liver, for example, have shown benefit when added to conventional therapy. Therefore, this review aims to contemplate some aspects of dyslipidemia in the elderly population, since appropriate management of such condition can significantly avoid undesirable outcomes.

scholarly journals Prognostic Nutritional Index After Chemoradiotherapy Was the Strongest Prognostic Predictor Among Biological and Conditional Factors in Localized Pancreatic Ductal Adenocarcinoma Patients

Cancers ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 514 ◽  
Author(s):  
Ichikawa ◽  
Mizuno ◽  
Hayasaki ◽  
Kishiwada ◽  
Fujii ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Prognostic Score ◽  
Glasgow Prognostic Score ◽  
Prognostic Nutritional Index ◽  
Ductal Adenocarcinoma ◽  
C Reactive Protein ◽  
Albumin Ratio ◽  
Reactive Protein ◽  
Nutritional Index

Background: In many malignancies, including pancreatic ductal adenocarcinoma (PDAC), host-related inflammatory/immunonutritional markers, such as the prognostic nutritional index (PNI), modified Glasgow prognostic score (mGPS), and C-reactive protein (CRP)/albumin ratio are reported to be prognostic factors. However, the prognostic influence of these factors before and after chemoradiotherapy (CRT) has not been studied in PDAC patients. Methods: Of 261 consecutive PDAC patients who were scheduled for CRT with gemcitabine or S1 plus gemcitabine between February 2005 and December 2015, participants in this study were 176 who completed CRT and had full data available on inflammatory/immunonutritional markers as well as on anatomical and biological factors for the investigation of prognostic/predictive factors. Results: In multivariate analysis, the significant prognostic factors were RECIST classification, cT category, performance status, post-CRT carcinoembryonic antigen, post-CRT C-reactive protein/albumin ratio, post-CRT mGPS, and post-CRT PNI. Post-CRT PNI (cut-off value, 39) was the strongest host-related prognostic factor according to the p-value. In the patients who underwent resection after CRT, median survival time (MST) was significantly shorter in the 12 patients with low PNI (<39) than in the 97 with high PNI (≥39), at 15.5 months versus 27.2 months, respectively (p = 0.0016). In the patients who did not undergo resection, MST was only 8.9 months in those with low PNI and 12.3 months in those with high PNI (p < 0.0001), and thus was similar to that of the resected patients with low PNI. Conclusions: Post-CRT PNI was the strongest prognostic/predictive indicator among the independent biological and conditional prognostic factors in PDAC patients who underwent CRT.

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