Uncoupling Protein-2 45-Base Pair Insertion/Deletion Polymorphism: Is There an Association with Severe Obesity and Weight Loss in Morbidly Obese Subjects?

The purpose of this study was to test the hypothesis that weight loss results in a reduction in intramuscular lipid (IMCL) content that is concomitant with enhanced insulin action. Muscle biopsies were obtained from morbidly obese individuals [body mass index (BMI) 52.2 ± 2.5 kg/m2; n= 6] before and after gastric bypass surgery, an intervention that improves insulin action. With intervention, there was a 47% reduction ( P < 0.01) in BMI and a 93% decrease in homeostasis model assessment, or HOMA (7.0 ± 1.9 vs. 0.5 ± 0.1). Histochemically determined IMCL content decreased ( P < 0.05) by ∼30%. In relation to fiber type, IMCL was significantly higher in type I vs. type II fibers. In both fiber types, there were reductions in IMCL and trends for muscle atrophy. Despite these two negating factors, the IMCL-to-fiber area ratio still decreased by ∼44% with weight loss. In conclusion, despite differing initial levels and possible atrophy, weight loss appears to decrease IMCL deposition to a similar relative extent in type I and II muscle fibers. This reduction in intramuscular triglyceride may contribute to enhanced insulin action seen with weight loss.

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Increase in Brown Adipose Tissue Activity after Weight Loss in Morbidly Obese Subjects

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2012-1289 ◽

2012 ◽

Vol 97 (7) ◽

pp. E1229-E1233 ◽

Cited By ~ 143

Author(s):

G. H. E. J. Vijgen ◽

N. D. Bouvy ◽

G. J. J. Teule ◽

B. Brans ◽

J. Hoeks ◽

...

Keyword(s):

Weight Loss ◽

Adipose Tissue ◽

Brown Adipose Tissue ◽

Morbidly Obese ◽

Brown Adipose ◽

Obese Subjects ◽

Brown Adipose Tissue Activity

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Changes in fat mass after initiation of maintenance dialysis is influenced by the uncoupling protein 2 exon 8 insertion/deletion polymorphism

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfl504 ◽

2006 ◽

Vol 22 (1) ◽

pp. 196-202 ◽

Cited By ~ 24

Author(s):

X. Wang ◽

J. Axelsson ◽

L. Nordfors ◽

A. R. Qureshi ◽

C. Avesani ◽

...

Keyword(s):

Fat Mass ◽

Uncoupling Protein ◽

Uncoupling Protein 2 ◽

Deletion Polymorphism ◽

Maintenance Dialysis

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Weight Loss and Metabolic Improvement in Morbidly Obese Subjects Implanted for 1 Year With an Endoscopic Duodenal-Jejunal Bypass Liner

Annals of Surgery ◽

10.1097/sla.0b013e31825498c4 ◽

2012 ◽

Vol 255 (6) ◽

pp. 1080-1085 ◽

Cited By ~ 82

Author(s):

Alex Escalona ◽

Fernando Pimentel ◽

Allan Sharp ◽

Pablo Becerra ◽

Milenko Slako ◽

...

Keyword(s):

Weight Loss ◽

Morbidly Obese ◽

Obese Subjects ◽

Jejunal Bypass

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The relationship between specialized pro-resolving lipid mediators, morbid obesity and weight loss after bariatric surgery

Scientific Reports ◽

10.1038/s41598-020-75353-6 ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Fabian Schulte ◽

Abdul Aziz Asbeutah ◽

Peter N. Benotti ◽

G. Craig Wood ◽

Christopher Still ◽

...

Keyword(s):

Bariatric Surgery ◽

Morbid Obesity ◽

Weight Loss ◽

White Blood Cells ◽

Diabetes Remission ◽

Lipid Mediators ◽

Morbidly Obese ◽

Post Surgery ◽

Obesity And Diabetes ◽

Obese Subjects

AbstractObesity and diabetes are associated with chronic inflammation. Specialized pro-resolving lipid mediators (SPMs)—resolvins (Rv), protectins (PD) and maresins (MaR)—actively resolve inflammation. Bariatric surgery achieves remission of diabetes, but mechanisms are unclear. We measured SPMs and proinflammatory eicosanoid levels using liquid chromatography-tandem mass spectrometry in 29 morbidly obese subjects (13 with diabetes) and 15 nondiabetic, mildly obese subjects. Compared to the mildly obese, the morbidly obese had higher levels of SPMs—RvD3, RvD4 and PD1—and white blood cells (WBC) and platelets. Post-surgery, SPM and platelet levels decreased in morbidly obese nondiabetic subjects but not in diabetic subjects, suggesting continued inflammation. Despite similar weight reductions 1 year after surgery (44.6% vs. 46.6%), 8 diabetes remitters had significant reductions in WBC and platelet counts whereas five non-remitters did not. Remitters had a 58.2% decrease (p = 0.03) in 14-HDHA, a maresin pathway marker; non-remitters had an 875.7% increase in 14-HDHA but a 36.9% decrease in MaR1 to a median of 0. In conclusion, higher levels of RvD3, PD1 and their pathway marker, 17-HDHA, are markers of leukocyte activation and inflammation in morbid obesity and diabetes and diminish with weight loss in nondiabetic but not diabetic subjects, possibly representing sustained inflammation in the latter. Lack of diabetes remission after surgically-induced weight loss may be associated with reduced ability to produce MaR1 and sustained inflammation.

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