Molecular Cloning and Function of Oct-3 Isoforms in Cynomolgus Monkey Embryonic Stem Cells

2006 ◽  
Vol 15 (4) ◽  
pp. 566-574 ◽  
Author(s):  
Yasuko Fujimoto ◽  
Kouichi Hasegawa ◽  
Hirofumi Suemori ◽  
Juichi Ito ◽  
Norio Nakatsuji
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Molecular Cloning ◽  
Cynomolgus Monkey ◽  
Embryonic Stem ◽  
And Function

Induction of Corneal Epithelium–Like Cells From Cynomolgus Monkey Embryonic Stem Cells and Their Experimental Transplantation to Damaged Cornea

Cornea ◽  
2010 ◽  
Vol 29 (4) ◽  
pp. 432-438 ◽  
Author(s):  
Yuta Kumagai ◽  
Manae S Kurokawa ◽  
Hiroki Ueno ◽  
Maki Kayama ◽  
Kazuo Tsubota ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Corneal Epithelium ◽  
Cynomolgus Monkey ◽  
Embryonic Stem

scholarly journals Perturbations of Heart Development and Function in Cardiomyocytes from Human Embryonic Stem Cells with Trisomy 21

Stem Cells ◽  
2015 ◽  
Vol 33 (5) ◽  
pp. 1434-1446 ◽  
Author(s):  
Alexis Bosman ◽  
Audrey Letourneau ◽  
Laura Sartiani ◽  
Martina Del Lungo ◽  
Flavio Ronzoni ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Heart Development ◽  
Trisomy 21 ◽  
Embryonic Stem ◽  
And Function

scholarly journals In Vitro Germ Cell Differentiation from Cynomolgus Monkey Embryonic Stem Cells

PLoS ONE ◽  
2009 ◽  
Vol 4 (4) ◽  
pp. e5338 ◽  
Author(s):  
Kaori Yamauchi ◽  
Kouichi Hasegawa ◽  
Shinichiro Chuma ◽  
Norio Nakatsuji ◽  
Hirofumi Suemori
Keyword(s):  
Stem Cells ◽  
Cell Differentiation ◽  
Embryonic Stem Cells ◽  
Germ Cell ◽  
Cynomolgus Monkey ◽  
Embryonic Stem ◽  
Germ Cell Differentiation

scholarly journals Genome-Wide Identification of Targets and Function of Individual MicroRNAs in Mouse Embryonic Stem Cells

PLoS Genetics ◽  
2010 ◽  
Vol 6 (10) ◽  
pp. e1001163 ◽  
Author(s):  
Sophie A. Hanina ◽  
William Mifsud ◽  
Thomas A. Down ◽  
Katsuhiko Hayashi ◽  
Dónal O'Carroll ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells ◽  
Genome Wide ◽  
And Function

scholarly journals Nucleosomal Asymmetry Shapes Histone Mark Binding and Promotes Poising at Bivalent Domains

2021 ◽  
Author(s):  
Elana Bryan ◽  
Marie Warburton ◽  
Kimberly M. Webb ◽  
Katy A. McLaughlin ◽  
Christos Spanos ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Neuronal Differentiation ◽  
Histone Acetyltransferase ◽  
Histone H3 ◽  
Embryonic Stem ◽  
Histone Mark ◽  
Developmental Genes ◽  
Chromatin Proteins ◽  
And Function

SummaryPromoters of developmental genes in embryonic stem cells (ESCs) are marked by histone H3 lysine 4 trimethylation (H3K4me3) and H3K27me3 in an asymmetric nucleosomal conformation, with each sister histone H3 carrying only one mark. These bivalent domains are thought to poise genes for timely activation upon differentiation. Here we show that asymmetric bivalent nucleosomes recruit repressive H3K27me3 binders but fail to enrich activating H3K4me3 binders, despite presence of H3K4me3, thereby promoting a poised state. Strikingly, the bivalent mark combination further attracts chromatin proteins that are not recruited by each mark individually, including the histone acetyltransferase complex KAT6B (MORF). Knockout of KAT6B blocks neuronal differentiation, demonstrating that bivalency-specific readers are critical for proper ESC differentiation. These findings reveal how histone mark bivalency directly promotes establishment of a poised state at developmental genes, while highlighting how nucleosomal asymmetry is critical for histone mark readout and function.

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