scholarly journals Epidemiology of Tick-Borne Encephalitis in the Czech Republic 1970–2008

2012 ◽  
Vol 12 (11) ◽  
pp. 994-999 ◽  
Author(s):  
Bohumir Kriz ◽  
Marek Maly ◽  
Cestmir Benes ◽  
Milan Daniel
2011 ◽  
Vol 92 (8) ◽  
pp. 1906-1916 ◽  
Author(s):  
M. Weidmann ◽  
D. Růžek ◽  
K. Křivanec ◽  
G. Zöller ◽  
S. Essbauer ◽  
...  

Tick-borne encephalitis virus (TBEV) is the most important arboviral agent causing disease of the central nervous system in central Europe. In this study, 61 TBEV E gene sequences derived from 48 isolates from the Czech Republic, and four isolates and nine TBEV strains detected in ticks from Germany, covering more than half a century from 1954 to 2009, were sequenced and subjected to phylogenetic and Bayesian phylodynamic analysis to determine the phylogeography of TBEV in central Europe. The general Eurasian continental east-to-west pattern of the spread of TBEV was confirmed at the regional level but is interlaced with spreading that arises because of local geography and anthropogenic influence. This spread is reflected by the disease pattern in the Czech Republic that has been observed since 1991. The overall evolutionary rate was estimated to be approximately 8×10−4 substitutions per nucleotide per year. The analysis of the TBEV E genes of 11 strains isolated at one natural focus in Žďár Kaplice proved for the first time that TBEV is indeed subject to local evolution.


2008 ◽  
Vol 298 ◽  
pp. 81-87 ◽  
Author(s):  
Milan Daniel ◽  
Bohumir Kříž ◽  
Vlasta Danielová ◽  
Čestmír Beneš

The TBE virus (TBEV) was first isolated in the Czech Republic by Czech scientists in 1948-1949 from both a patient and also from Ixodes ricinus ticks. However, even before 1948, etiologically unclear summer cases of viral meningoencephalitis had been reported, and likely, at least in part, they are attributable to the TBE virus. These cases were reported mostly from patients in the districts of Beroun (Central Bohemia), Hradec Králové (East Bohemia), Vyškov (South Moravia), and occasionally from the neighborhood of Prague. The official reports of these probable cases of ”tick-borne encephalitis” were registered in the database of the National Institute of Public Health in Prague since 1945.


2013 ◽  
Vol 94 (9) ◽  
pp. 2129-2139 ◽  
Author(s):  
Manfred Weidmann ◽  
Stefan Frey ◽  
Caio C. M. Freire ◽  
Sandra Essbauer ◽  
Daniel Růžek ◽  
...  

In order to obtain a better understanding of tick-borne encephalitis virus (TBEV) strain movements in central Europe the E gene sequences of 102 TBEV strains collected from 1953 to 2011 at 38 sites in the Czech Republic, Slovakia, Austria and Germany were determined. Bayesian analysis suggests a 350-year history of evolution and spread in central Europe of two main lineages, A and B. In contrast to the east to west spread at the Eurasian continent level, local central European spreading patterns suggest historic west to east spread followed by more recent east to west spread. The phylogenetic and network analyses indicate TBEV ingressions from the Czech Republic and Slovakia into Germany via landscape features (Danube river system), biogenic factors (birds, red deer) and anthropogenic factors. The identification of endemic foci showing local genetic diversity is of paramount importance to the field as these will be a prerequisite for in-depth analysis of focal TBEV maintenance and long-distance TBEV spread.


2014 ◽  
Vol 14 (11) ◽  
pp. 801-807 ◽  
Author(s):  
Bohumir Kriz ◽  
Milan Daniel ◽  
Cestmir Benes ◽  
Marek Maly

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