scholarly journals Relation of genetic phylogeny and geographical distance of tick-borne encephalitis virus in central Europe

2011 ◽  
Vol 92 (8) ◽  
pp. 1906-1916 ◽  
Author(s):  
M. Weidmann ◽  
D. Růžek ◽  
K. Křivanec ◽  
G. Zöller ◽  
S. Essbauer ◽  
...  
Keyword(s):  
Czech Republic ◽  
Central Europe ◽  
Encephalitis Virus ◽  
Natural Focus ◽  
The Czech Republic ◽  
Tick Borne Encephalitis ◽  
Disease Pattern ◽  
The Central Nervous System ◽  
Tick Borne Encephalitis Virus ◽  
First Time

Tick-borne encephalitis virus (TBEV) is the most important arboviral agent causing disease of the central nervous system in central Europe. In this study, 61 TBEV E gene sequences derived from 48 isolates from the Czech Republic, and four isolates and nine TBEV strains detected in ticks from Germany, covering more than half a century from 1954 to 2009, were sequenced and subjected to phylogenetic and Bayesian phylodynamic analysis to determine the phylogeography of TBEV in central Europe. The general Eurasian continental east-to-west pattern of the spread of TBEV was confirmed at the regional level but is interlaced with spreading that arises because of local geography and anthropogenic influence. This spread is reflected by the disease pattern in the Czech Republic that has been observed since 1991. The overall evolutionary rate was estimated to be approximately 8×10−4 substitutions per nucleotide per year. The analysis of the TBEV E genes of 11 strains isolated at one natural focus in Žďár Kaplice proved for the first time that TBEV is indeed subject to local evolution.

scholarly journals Molecular phylogeography of tick-borne encephalitis virus in central Europe

2013 ◽  
Vol 94 (9) ◽  
pp. 2129-2139 ◽  
Author(s):  
Manfred Weidmann ◽  
Stefan Frey ◽  
Caio C. M. Freire ◽  
Sandra Essbauer ◽  
Daniel Růžek ◽  
...  
Keyword(s):  
Czech Republic ◽  
Central Europe ◽  
Encephalitis Virus ◽  
Danube River ◽  
Long Distance ◽  
The Czech Republic ◽  
Tick Borne Encephalitis ◽  
Tbev Strain ◽  
Depth Analysis ◽  
Tick Borne Encephalitis Virus

In order to obtain a better understanding of tick-borne encephalitis virus (TBEV) strain movements in central Europe the E gene sequences of 102 TBEV strains collected from 1953 to 2011 at 38 sites in the Czech Republic, Slovakia, Austria and Germany were determined. Bayesian analysis suggests a 350-year history of evolution and spread in central Europe of two main lineages, A and B. In contrast to the east to west spread at the Eurasian continent level, local central European spreading patterns suggest historic west to east spread followed by more recent east to west spread. The phylogenetic and network analyses indicate TBEV ingressions from the Czech Republic and Slovakia into Germany via landscape features (Danube river system), biogenic factors (birds, red deer) and anthropogenic factors. The identification of endemic foci showing local genetic diversity is of paramount importance to the field as these will be a prerequisite for in-depth analysis of focal TBEV maintenance and long-distance TBEV spread.

Tick-Borne Encephalitis Virus in Clethrionomys glareolus in the Czech Republic

2006 ◽  
Vol 6 (4) ◽  
pp. 379-381 ◽  
Author(s):  
Manfred Weidmann ◽  
Peter Schmidt ◽  
Frank T. Hufert ◽  
Karel Krivanec ◽  
Hermann Meyer
Keyword(s):  
Czech Republic ◽  
Encephalitis Virus ◽  
Clethrionomys Glareolus ◽  
The Czech Republic ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus

scholarly journals Tick-Borne Encephalitis Virus: A Quest for Better Vaccines against a Virus on the Rise

Vaccines ◽  
2020 ◽  
Vol 8 (3) ◽  
pp. 451 ◽  
Author(s):  
Mareike Kubinski ◽  
Jana Beicht ◽  
Thomas Gerlach ◽  
Asisa Volz ◽  
Gerd Sutter ◽  
...  
Keyword(s):  
Antiviral Treatment ◽  
Encephalitis Virus ◽  
Protective Measure ◽  
Humoral And Cellular Immunity ◽  
Tick Borne Encephalitis ◽  
The Family ◽  
The Central Nervous System ◽  
Tick Borne Encephalitis Virus ◽  
Protection Against Infection ◽  
Vaccine Failures

Tick-borne encephalitis virus (TBEV), a member of the family Flaviviridae, is one of the most important tick-transmitted viruses in Europe and Asia. Being a neurotropic virus, TBEV causes infection of the central nervous system, leading to various (permanent) neurological disorders summarized as tick-borne encephalitis (TBE). The incidence of TBE cases has increased due to the expansion of TBEV and its vectors. Since antiviral treatment is lacking, vaccination against TBEV is the most important protective measure. However, vaccination coverage is relatively low and immunogenicity of the currently available vaccines is limited, which may account for the vaccine failures that are observed. Understanding the TBEV-specific correlates of protection is of pivotal importance for developing novel and improved TBEV vaccines. For affording robust protection against infection and development of TBE, vaccines should induce both humoral and cellular immunity. In this review, the adaptive immunity induced upon TBEV infection and vaccination as well as novel approaches to produce improved TBEV vaccines are discussed.

scholarly journals Astrocytes in Flavivirus Infections

2019 ◽  
Vol 20 (3) ◽  
pp. 691 ◽  
Author(s):  
Maja Potokar ◽  
Jernej Jorgačevski ◽  
Robert Zorec
Keyword(s):  
Cell Types ◽  
Encephalitis Virus ◽  
Neural Cells ◽  
Virus Infections ◽  
Neurotropic Viruses ◽  
Neuronal Synapses ◽  
Tick Borne Encephalitis ◽  
The Central Nervous System ◽  
Tick Borne Encephalitis Virus ◽  
New Strategies

Virus infections of the central nervous system (CNS) can manifest in various forms of inflammation, including that of the brain (encephalitis) and spinal cord (myelitis), all of which may have long-lasting deleterious consequences. Although the knowledge of how different viruses affect neural cells is increasing, understanding of the mechanisms by which cells respond to neurotropic viruses remains fragmented. Several virus types have the ability to infect neural tissue, and astrocytes, an abundant and heterogeneous neuroglial cell type and a key element providing CNS homeostasis, are one of the first CNS cell types to get infected. Astrocytes are morphologically closely aligned with neuronal synapses, blood vessels, and ventricle cavities, and thereby have the capacity to functionally interact with neurons and endothelial cells. In this review, we focus on the responses of astrocytes to infection by neurotropic flaviviruses, including tick-borne encephalitis virus (TBEV), Zika virus (ZIKV), West Nile virus (WNV), and Japanese encephalitis virus (JEV), which have all been confirmed to infect astrocytes and cause multiple CNS defects. Understanding these mechanisms may help design new strategies to better contain and mitigate virus- and astrocyte-dependent neuroinflammation.

scholarly journals Tick-Borne Encephalitis Virus Habitats in North East Germany: Reemergence of TBEV in Ticks after 15 Years of Inactivity

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Silvius Frimmel ◽  
Anja Krienke ◽  
Diana Riebold ◽  
Micha Loebermann ◽  
Martina Littmann ◽  
...  
Keyword(s):  
Human Case ◽  
Encephalitis Virus ◽  
Federal State ◽  
Natural Focus ◽  
North East ◽  
Tick Borne Encephalitis ◽  
Close Relationship ◽  
Natural Foci ◽  
Tick Borne Encephalitis Virus ◽  
Migrating Birds

The incidence of tick-borne encephalitis has risen in Europe since 1990 and the tick-borne encephalitis virus (TBEV) has been documented to be spreading into regions where it was not previously endemic. In Mecklenburg-West Pomerania, a federal state in Northern Germany, TBEV was not detectable in over 16,000 collected ticks between 1992 and 2004. Until 2004, the last human case of TBE in the region was reported in 1985. Following the occurrence of three autochthonous human cases of TBE after 2004, however, we collected ticks from the areas in which the infections were contracted. To increase the chance of detecting TBEV-RNA, some of the ticks were fed on mice. Using nested RT-PCR, we were able to confirm the presence of TBEV in ticks for the first time after 15 years. A phylogenetic analysis revealed a close relationship between the sequences we obtained and a TBEV sequence from Mecklenburg-East Pomerania published in 1992 and pointed to the reemergence of a natural focus of TBEV after years of low activity. Our results imply that natural foci of TBEV may either persist at low levels of activity for years or reemerge through the agency of migrating birds.

Chrysoclista karsholti, sp. n., from Turkey, and a new record of C. germanica from central Europe (Lepidoptera: Elachistidae: Parametriotinae)

Zootaxa ◽  
2019 ◽  
Vol 4568 (3) ◽  
pp. 587
Author(s):  
JAN ŠUMPICH ◽  
JOSEF JAROŠ
Keyword(s):  
Czech Republic ◽  
Central Europe ◽  
Male Genitalia ◽  
New Record ◽  
Dna Barcode ◽  
Single Male ◽  
The Czech Republic ◽  
Western Palaearctic ◽  
First Time

Chrysoclista karsholti Šumpich, sp. n., is described from a single male collected in Turkey. This species most resembles C. germanica Šumpich & Huemer, 2016, but differs in the colouration of the dorsum of the forewing and in the shape of the valva in the male genitalia. Differences in the DNA barcode region between these two species are rather low compared to differences between other species of the genus. Chrysoclista germanica, previously known only from the holotype, is recorded from the Czech Republic for the first time. An updated checklist of western Palaearctic Chrysoclista Stainton, 1854 is provided. 

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