ABSTRACT
We
have designed a glycodendritic structure, BH30sucMan, that blocks the
interaction between dendritic cell-specific intercellular adhesion
molecule 3-grabbing nonintegrin (DC-SIGN) and Ebola virus (EBOV)
envelope. BH30sucMan inhibits DC-SIGN-mediated EBOV infection at
nanomolar concentrations. BH30sucMan may counteract
important steps of the infective process of EBOV and, potentially, of
microorganisms shown to exploit DC-SIGN for cell entry and
infection.