2. Montaigne’s life: a sketch

2020 ◽  
pp. 15-31
Author(s):  
William M. Hamlin
Keyword(s):  
Early Retirement ◽  
Early Adulthood ◽  
Early Death ◽  
Political Life ◽  
Active Part ◽  
Etienne De La Boetie

“Montaigne’s life—a sketch” covers Montaigne’s culturally rich childhood and his profound friendship with the poet Étienne de La Boétie in early adulthood, which was curtailed by La Boétie’s early death. Montaigne took an active part in political life. His early “retirement” to the country, where he wrote the Essays, was not final. Having gained a reputation as a mediator between warring Catholic and Protestant factions, he retired again at fifty-two. Montaigne’s hopes that his writings might lead to another deep friendship were partly realized in his mentorship of Marie de Gournay, one of his first editors, who spent many years promoting his work after his death at fifty-nine.

Forty Hall, Enfield: Continuity and Innovation in a Carolean Gentry House

2008 ◽  
Vol 51 ◽  
pp. 33-62 ◽  
Author(s):  
Richard Peats
Keyword(s):  
Civil War ◽  
Political Life ◽  
Active Part ◽  
Italian Renaissance ◽  
The City

Forty Hall, built in 1629 for Nicholas Rainton (1569–1646), is one of a group of Jacobean and Carolean suburban villas around London. This type of house has its antecedents in medieval secret houses and Tudor lodges, and was influenced by Italian Renaissance models. It provided a convenient escape from the bustle and squalor of the City, whilst being close enough to stay in touch with business or court, and so was popular with aristocrats and merchants alike.Rainton was one of the latter, a wealthy London merchant who imported fine textiles, principally satin and taffeta, from Florence and Genoa. He took an active part in the corporate and political life of the City, including serving as Alderman of Aldgate Ward from 1621, Sheriff of the Ward in 1622 and Lord Mayor in 1632–33. He was also master of the Haberdashers’ Company in 1622–23 and 1632–33. His religious sympathies were firmly Puritan, and he consistently sided with Parliament in its disputes with the Crown in events leading up to the Civil War.

scholarly journals IDEOLOGY, RACE, AND ART: JAMES BALDWIN’S LEGACY

2019 ◽  
Vol 29 (5) ◽  
pp. 853-858
Author(s):  
Yu.V. Stulov
Keyword(s):  
African American ◽  
Black Population ◽  
James Baldwin ◽  
Political Life ◽  
Active Part ◽  
American People ◽  
African American People ◽  
American Writer ◽  
The Us ◽  
The Usa

In the 1950s-60s the outstanding African American writer James Baldwin took an active part in the events of the so-called Black Revolution in the USA, which had a tremendous effect on the country’s social and political life for the following years. African American people of art got strongly divided into two camps on the ideological issues. Baldwin belonged to the integrationists who did not separate their fate from the fate of America and insisted on the decisive measures to be taken by the US administration to change the attitude towards the black population. His position as well as his works written at that period aroused severe criticism on the part of the Black radicals. Time took care of it, but Baldwin’s lesson is important for understanding the problems of the connection between ideology and art.

Apoetm1Unc mice have impaired alveologenesis, low lung function, and rapid loss of lung function

2008 ◽  
Vol 294 (5) ◽  
pp. L991-L997 ◽  
Author(s):  
Donald Massaro ◽  
Gloria DeCarlo Massaro
Keyword(s):  
Lung Function ◽  
Apolipoprotein E ◽  
Early Adulthood ◽  
Early Death ◽  
Forced Expiratory Volume ◽  
Early Mortality ◽  
Accelerated Ageing ◽  
Rapid Loss ◽  
Apolipoprotein E Genotypes ◽  
Never Smokers

Diminished lung function, indicated by a low forced expiratory volume in one second (FEV1), and short physical stature, predict early mortality from all causes, including cardiovascular, among smokers and never smokers. The basis for these associations is unclear, and, it is not known if there is a pulmonary morphological component to the relationship between low FEV1 and early death in a general population. Some apolipoprotein E genotypes also predict atherosclerosis and early mortality. These considerations led us to examine the Apoe tm1Unc (Apoe) mouse, in which the apolipoprotein E gene is deleted, and that develops dyslipidemia, atherosclerosis at an early age, and has a shorter life span than the founder wild-type (wt) strain. We asked if Apoe mice have a morphological or functional pulmonary phenotype. We measured the size, number, and surface area of pulmonary gas-exchange units (alveoli) and mechanical properties of the lung. Compared with wt mice, Apoe mice had: 1) diminished developmental alveologenesis, 2) increased airway resistance in early adulthood, 3) high lung volume and high dynamic and static compliance in later adulthood, 4) more rapid loss of lung recoil with age, and 5) were less long than wt mice. These findings in mice indicate the association of a low FEV1 with early death in humans may have developmental, and accelerated ageing, related pulmonary components, and that dietary, genetic, or dietary and genetic influences, on lipid metabolism may be an upstream cause of inflammation and oxidative stress, currently considered to be major risk factors for COPD.

Psychosocial Risks and Management for Children and Adolescents With 22q11.2 Deletion Syndrome

2019 ◽  
Vol 4 (4) ◽  
pp. 633-640 ◽  
Author(s):  
Canice E. Crerand ◽  
Ari N. Rabkin
Keyword(s):  
Cognitive Abilities ◽  
Psychotic Disorders ◽  
Developmental Stages ◽  
Early Adulthood ◽  
22Q11.2 Deletion Syndrome ◽  
Deletion Syndrome ◽  
22Q11.2 Deletion ◽  
Psychosocial Risks ◽  
Empirically Supported ◽  
Specific Education

Purpose This article reviews the psychosocial risks associated with 22q11.2 deletion syndrome, a relatively common genetic condition associated with a range of physical and psychiatric problems. Risks associated with developmental stages from infancy through adolescence and early adulthood are described, including developmental, learning, and intellectual disabilities as well as psychiatric disorders including anxiety, mood, and psychotic disorders. Other risks related to coping with health problems and related treatments are also detailed for both affected individuals and their families. Conclusion The article ends with strategies for addressing psychosocial risks including provision of condition-specific education, enhancement of social support, routine assessment of cognitive abilities, regular mental health screening, and referrals for empirically supported psychiatric and psychological treatments.

193: The Relative Risk of Early Death from Comorbid Illnesses among Prostate Cancer Patients Receiving Curative Treatment

2005 ◽  
Vol 173 (4S) ◽  
pp. 53-53 ◽  
Author(s):  
Patti A. Groome ◽  
Susan L. Rohland ◽  
Michael D. Brundage ◽  
Jeremy P.W. Heaton ◽  
William J. Mackillop ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Relative Risk ◽  
Cancer Patients ◽  
Early Death ◽  
Curative Treatment

Inflammational Animal Models for Schizophrenia

2015 ◽  
Vol 223 (3) ◽  
pp. 157-164 ◽  
Author(s):  
Georg Juckel
Keyword(s):  
Animal Model ◽  
Animal Models ◽  
Immune Activation ◽  
Microglial Activation ◽  
Treatment Options ◽  
Early Adulthood ◽  
Brain Regions ◽  
Synaptic Connections ◽  
Preventive Interventions ◽  
Immunological System

Abstract. Inflammational-immunological processes within the pathophysiology of schizophrenia seem to play an important role. Early signals of neurobiological changes in the embryonal phase of brain in later patients with schizophrenia might lead to activation of the immunological system, for example, of cytokines and microglial cells. Microglia then induces – via the neurotoxic activities of these cells as an overreaction – a rarification of synaptic connections in frontal and temporal brain regions, that is, reduction of the neuropil. Promising inflammational animal models for schizophrenia with high validity can be used today to mimic behavioral as well as neurobiological findings in patients, for example, the well-known neurochemical alterations of dopaminergic, glutamatergic, serotonergic, and other neurotransmitter systems. Also the microglial activation can be modeled well within one of this models, that is, the inflammational PolyI:C animal model of schizophrenia, showing a time peak in late adolescence/early adulthood. The exact mechanism, by which activated microglia cells then triggers further neurodegeneration, must now be investigated in broader detail. Thus, these animal models can be used to understand the pathophysiology of schizophrenia better especially concerning the interaction of immune activation, inflammation, and neurodegeneration. This could also lead to the development of anti-inflammational treatment options and of preventive interventions.

Review of The Course of Life: Volume V, Early Adulthood.

1994 ◽  
Vol 39 (6) ◽  
pp. 676-676
Author(s):  
Terri Gullickson ◽  
Pamela Ramser
Keyword(s):  
Early Adulthood
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