Controlled trial of the metabolic effects of a very-low-calorie diet: short- and long-term effects

1990 ◽  
Vol 51 (2) ◽  
pp. 167-172 ◽  
Author(s):  
G D Foster ◽  
T A Wadden ◽  
I D Feurer ◽  
A S Jennings ◽  
A J Stunkard ◽  
...  
Keyword(s):  
Controlled Trial ◽  
Metabolic Effects ◽  
Long Term Effects ◽  
Very Low Calorie Diet ◽  
Low Calorie ◽  
Low Calorie Diet ◽  
Calorie Diet ◽  
Short And Long Term

scholarly journals Protocol for a randomised controlled trial of the combined effects of the GLP-1 receptor agonist liraglutide and exercise on maintenance of weight loss and health after a very low-calorie diet

BMJ Open ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. e031431
Author(s):  
Simon Birk Kjær Jensen ◽  
Julie Rehné Lundgren ◽  
Charlotte Janus ◽  
Christian Rimer Juhl ◽  
Lisa Møller Olsen ◽  
...  
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Receptor Agonist ◽  
Controlled Trial ◽  
Good Clinical Practice ◽  
Study Groups ◽  
Very Low Calorie Diet ◽  
Low Calorie ◽  
Low Calorie Diet ◽  
Calorie Diet

IntroductionThe success rate of weight loss maintenance is limited. Therefore, the purpose of this study is to investigate the maintenance of weight loss and immunometabolic health outcomes after diet-induced weight loss followed by 1-year treatment with a glucagon-like peptide-1 receptor agonist (liraglutide), physical exercise or the combination of both treatments as compared with placebo in individuals with obesity.Methods and analysisThis is an investigator-initiated, randomised, placebo-controlled, parallel group trial. We will enrol expectedly 200 women and men (age 18–65 years) with obesity (body mass index 32–43 kg/m2) to adhere to a very low-calorie diet (800 kcal/day) for 8 weeks in order to lose at least 5% of body weight. Subsequently, participants will be randomised in a 1:1:1:1 ratio to one of four study groups for 52 weeks: (1) placebo, (2) exercise 150 min/week+placebo, (3) liraglutide 3.0 mg/day and (4) exercise 150 min/week+liraglutide 3.0 mg/day. The primary endpoint is change in body weight from randomisation to end-of-treatment.Ethics and disseminationThe trial has been approved by the ethical committee of the Capital Region of Denmark and the Danish Medicines Agency. The trial will be conducted in agreement with the Declaration of Helsinki and monitored to follow the guidelines for good clinical practice. Results will be submitted for publication in international peer-reviewed scientific journals.Trial registration number2015-005585-32

Erythrocyte Na-K-ATPase membrane activity in obese patients fed over a long-term period with a very-low-calorie diet

Metabolism ◽  
1988 ◽  
Vol 37 (1) ◽  
pp. 86-90 ◽  
Author(s):  
Renato Pasquali ◽  
Maria Paola Cesari ◽  
Nazario Melchionda ◽  
Stefano Boschi ◽  
Alessandra Munarini ◽  
...  
Keyword(s):  
Obese Patients ◽  
Very Low Calorie Diet ◽  
Low Calorie ◽  
Membrane Activity ◽  
Low Calorie Diet ◽  
Calorie Diet

Long-term maintenance of weight loss after a very-low-calorie diet: a randomized blinded trial of the efficacy and tolerability of sibutramine

1999 ◽  
Vol 106 (2) ◽  
pp. 179-184 ◽  
Author(s):  
Marian Apfelbaum ◽  
Philippe Vague ◽  
Olivier Ziegler ◽  
Corinne Hanotin ◽  
Florence Thomas ◽  
...  
Keyword(s):  
Weight Loss ◽  
Very Low Calorie Diet ◽  
Low Calorie ◽  
Low Calorie Diet ◽  
Calorie Diet ◽  
Term Maintenance ◽  
Blinded Trial
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