scholarly journals Addition of inulin to a moderately high-carbohydrate diet reduces hepatic lipogenesis and plasma triacylglycerol concentrations in humans

2003 ◽  
Vol 77 (3) ◽  
pp. 559-564 ◽  
Author(s):  
Dominique Letexier ◽  
Frédérique Diraison ◽  
Michel Beylot
Keyword(s):  
High Carbohydrate Diet ◽  
Hepatic Lipogenesis ◽  
Carbohydrate Diet ◽  
High Carbohydrate ◽  
Plasma Triacylglycerol

scholarly journals Exercise prevents the augmentation of postprandial lipaemia attributable to a low-fat high-carbohydrate diet

2001 ◽  
Vol 86 (2) ◽  
pp. 197-205 ◽  
Author(s):  
Christina Koustsair ◽  
Adrianne E. Hardman
Keyword(s):  
Dietary Fat ◽  
High Carbohydrate Diet ◽  
Western Diet ◽  
Short Term ◽  
Carbohydrate Diet ◽  
Postprandial Lipaemia ◽  
Time Curve ◽  
High Carbohydrate ◽  
Daily Exercise ◽  
Plasma Triacylglycerol

There is concern that replacement of dietary fat with carbohydrate may not reduce the overall risk of CHD because this replacement strategy elevates postprandial plasma triacylglycerol (TAG) concentrations. The present study was designed to test the hypothesis that daily exercise can offset the augmented postprandial lipaemia associated with a short-term high-carbohydrate diet. Nine healthy, normolipidaemic men aged 33 (SD 4) YEARS CONSUMED A TEST MEAL (G/KG BODY MASS; 1·2 FAT, 1·1 CARBOHYDRATE, 0·2 PROTEIN) ON THREE OCCASIONS: AFTER 3 D ON A TYPICAL WESTERN DIET (46, 38 AND 16 % ENERGY FROM CARBOHYDRATE, FAT AND PROTEIN RESPECTIVELY); AFTER 3 D ON AN ISOENERGETIC HIGH-CARBOHYDRATE DIET (CORRESPONDING VALUES: 70, 15 AND 15 % ENERGY); AFTER 3 D ON THE SAME HIGH-CARBOHYDRATE DIET WITH 30 MIN MODERATE EXERCISE DAILY. FASTING PLASMA TAG CONCENTRATION WAS HIGHER AFTER THE HIGH-CARBOHYDRATE DIET (1·15 (se 0·16) mmol/l) than after the Western diet (0·83 (se 0·10) mmol/l; P=0·03). Similarly, postprandial lipaemia (6 h total area under plasma TAG concentrationv.time curve) was higher after the high-carbohydrate diet (12·54 (se 2·07) mmol/l·h) than after the Western diet (9·30 (se 1·30) mmol/l·h; P=0·004). The addition of exercise to the high-carbohydrate diet significantly reduced postprandial lipaemia (9·95 (se 1·94) mmol/l·h; P=0·01 when compared with the high-carbohydrate diet) but not fasting TAG concentration (1·02 (se 0·24) mmol/l). In conclusion, daily exercise prevented the augmentation of postprandial lipaemia attributable to the short-term high-carbohydrate diet and, thus, exercise may be a powerful adjunct to dietary change.

Metabolism of glucose-1-C14 and glucose-6-C14 by liver slices of refed rats

1961 ◽  
Vol 200 (5) ◽  
pp. 1069-1073 ◽  
Author(s):  
Jay Tepperman ◽  
Helen M. Tepperman
Keyword(s):  
Glucose Metabolism ◽  
Dehydrogenase Activity ◽  
High Carbohydrate Diet ◽  
Hepatic Lipogenesis ◽  
Carbohydrate Diet ◽  
High Carbohydrate ◽  
Direct Pathway ◽  
Liver Slices ◽  
Temporal Relationships ◽  
Glycogen Deposition

Rats starved for 48 hours and refed a high carbohydrate diet show an increase in hepatic lipogenesis and a marked increase in activity of the enzymes of entry into the HMP shunt. An analysis is given of the patterns of glucose-1-C14 and -6-C14 metabolism in liver slices of refed rats. At 24 and 48 hours the ratios of carbons 1 and 6 in both CO2 and lipid are consistent with an increase in glucose metabolism via the direct pathway, especially in view of the previous finding of elevated HMP dehydrogenase activity under these conditions. In addition, a description is given of the temporal relationships of glycogen deposition, lipogenesis recovery, and differentially labeled glucose metabolism in the first 12 hours of refeeding.

scholarly journals NF-κB p65 regulates hepatic lipogenesis by promoting nuclear entry of ChREBP in response to a high carbohydrate diet

2021 ◽  
pp. 100714
Author(s):  
P. Vineeth Daniel ◽  
Surbhi Dogra ◽  
Priya Rawat ◽  
Abhinav Choubey ◽  
Aiysha Siddiq Khan ◽  
...  
Keyword(s):  
High Carbohydrate Diet ◽  
Hepatic Lipogenesis ◽  
Nuclear Entry ◽  
Carbohydrate Diet ◽  
High Carbohydrate

scholarly journals High Carbohydrate Diet Increased Glucose Transporter Protein Levels in Jejunum but Did Not Lead to Enhanced Post-Exercise Skeletal Muscle Glycogen Recovery

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2140
Author(s):  
Yumiko Takahashi ◽  
Yutaka Matsunaga ◽  
Hiroki Yoshida ◽  
Terunaga Shinya ◽  
Ryo Sakaguchi ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Glucose Transporter ◽  
High Carbohydrate Diet ◽  
Oral Glucose ◽  
Carbohydrate Diet ◽  
Post Exercise ◽  
Glucose Administration ◽  
Protein Levels ◽  
High Carbohydrate ◽  
Glucose Transporter 2

We examined the effect of dietary carbohydrate intake on post-exercise glycogen recovery. Male Institute of Cancer Research (ICR) mice were fed moderate-carbohydrate chow (MCHO, 50%cal from carbohydrate) or high-carbohydrate chow (HCHO, 70%cal from carbohydrate) for 10 days. They then ran on a treadmill at 25 m/min for 60 min and administered an oral glucose solution (1.5 mg/g body weight). Compared to the MCHO group, the HCHO group showed significantly higher sodium-D-glucose co-transporter 1 protein levels in the brush border membrane fraction (p = 0.003) and the glucose transporter 2 level in the mucosa of jejunum (p = 0.004). At 30 min after the post-exercise glucose administration, the skeletal muscle and liver glycogen levels were not significantly different between the two diet groups. The blood glucose concentration from the portal vein (which is the entry site of nutrients from the gastrointestinal tract) was not significantly different between the groups at 15 min after the post-exercise glucose administration. There was no difference in the total or phosphorylated states of proteins related to glucose uptake and glycogen synthesis in skeletal muscle. Although the high-carbohydrate diet significantly increased glucose transporters in the jejunum, this adaptation stimulated neither glycogen recovery nor glucose absorption after the ingestion of post-exercise glucose.

scholarly journals Improvement of Obesity and Dyslipidemic Activity of Amomum tsao-ko in C57BL/6 Mice Fed a High-Carbohydrate Diet

Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1638
Author(s):  
Ju-Hyoung Park ◽  
Eun-Kyung Ahn ◽  
Min Hee Hwang ◽  
Young Jin Park ◽  
Young-Rak Cho ◽  
...  
Keyword(s):  
Body Weight Gain ◽  
Subcutaneous Fat ◽  
Density Lipoprotein ◽  
Ethanol Extract ◽  
Cardiac Risk ◽  
Normal Diet ◽  
High Carbohydrate Diet ◽  
Atherogenic Index ◽  
Carbohydrate Diet ◽  
High Carbohydrate

Amomum tsao-ko Crevost et Lemaire (Zingiberaceae) is a medicinal herb found in Southeast Asia that is used for the treatment of malaria, abdominal pain, dyspepsia, etc. The aim of this study was to investigate the effect of an ethanol extract of Amomum tsao-ko (EAT) on obesity and hyperlipidemia in C57BL/6 mice fed a high-carbohydrate diet (HCD). First, the mice were divided into five groups (n = 6/group) as follows: normal diet, HCD, and HCD+EAT (100, 200, and 400 mg/kg/day), which were orally administered with EAT daily for 84 days. Using microcomputed tomography (micro-CT) analysis, we found that EAT inhibited not only body-weight gain, but also visceral fat and subcutaneous fat accumulation. Histological analysis confirmed that EAT decreased the size of fat tissues. EAT consistently improved various indices, including plasma levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein, high-density lipoprotein, atherogenic index, and cardiac risk factors, which are related to dyslipidemia—a major risk factor for heart disease. The contents of TC and TG, as well as the lipid droplets of HCD-induced hepatic accumulation in the liver tissue, were suppressed by EAT. Taken together, these findings suggest the possibility of developing EAT as a therapeutic agent for improving HCD-induced obesity and hyperlipidemia.

scholarly journals Mixed lineage kinase 3 deficient mice are protected against the high fat high carbohydrate diet-induced steatohepatitis

2013 ◽  
Vol 34 (3) ◽  
pp. 427-437 ◽  
Author(s):  
Samar H. Ibrahim ◽  
Gregory J. Gores ◽  
Petra Hirsova ◽  
Michelle Kirby ◽  
Lili Miles ◽  
...  
Keyword(s):  
High Carbohydrate Diet ◽  
High Fat ◽  
Carbohydrate Diet ◽  
Mixed Lineage Kinase ◽  
High Carbohydrate ◽  
Mixed Lineage Kinase 3 ◽  
Deficient Mice

scholarly journals The Bacteriological Examinations of the Faeces in Four Cases of Typhoid Fever, made at frequent intervals for a period of one month

1924 ◽  
Vol 23 (1) ◽  
pp. 106-116 ◽  
Author(s):  
Leonard P. Lockhart
Keyword(s):  
Typhoid Fever ◽  
Physical State ◽  
Intestinal Flora ◽  
High Carbohydrate Diet ◽  
The Body ◽  
Causative Organism ◽  
Carbohydrate Diet ◽  
High Carbohydrate ◽  
Large Numbers

1. The appearance and disappearance of typhoid bacilli in the faeces in these four cases bore no relation to changes in the diet nor to the physical state of the stools, but the later they appeared the shorter was the duration of their appearance.On the disappearance of typhoid bacilli from the stools the intestinal flora tended to become more simple.2. B. coli was the only organism invariably present at every examination.3. Streptococci were very much more abundant in the earlier stages of the disease, when milk formed the greater part of the diet, than in the later stages.4. In two cases where boils occurred on the body the causative organism had previously been isolated in large numbers from the faeces.5. With stools slightly alkaline to litmus the flora in these cases was relatively simple and fermentative in type. There is no apparent advantage, therefore, in giving a high carbohydrate diet except in cases of marked alkalinity and putrefaction.

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