scholarly journals Regional body composition in adolescents with anorexia nervosa and changes with weight recovery

2003 ◽  
Vol 77 (6) ◽  
pp. 1361-1367 ◽  
Author(s):  
Madhusmita Misra ◽  
Leslie A Soyka ◽  
Karen K Miller ◽  
Steven Grinspoon ◽  
Lynne L Levitsky ◽  
...  
Author(s):  
Peter Schneider ◽  
J. Biko ◽  
D. Schlamp ◽  
G.-E. Trott ◽  
F. Badura ◽  
...  

2005 ◽  
Vol 90 (5) ◽  
pp. 2580-2587 ◽  
Author(s):  
Madhusmita Misra ◽  
Karen K. Miller ◽  
Cecilia Almazan ◽  
Megan Worley ◽  
David B. Herzog ◽  
...  

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1096
Author(s):  
Spyridon Tsirigkakis ◽  
George Mastorakos ◽  
Yiannis Koutedakis ◽  
Vassilis Mougios ◽  
Alan M. Nevill ◽  
...  

The effects of two high-intensity interval training (HIIT) protocols on regional body composition and fat oxidation in men with obesity were compared using a parallel randomized design. Sixteen inactive males (age, 38.9 ± 7.3 years; body fat, 31.8 ± 3.9%; peak oxygen uptake, VO2peak, 30.9 ± 4.1 mL/kg/min; all mean ± SD) were randomly assigned to either HIIT10 (48 × 10 s bouts at 100% of peak power [Wpeak] with 15 s of recovery) or HIIT60 group (8 × 60 s bouts at 100% Wpeak with 90 s of recovery), and subsequently completed eight weeks of training, while maintaining the same diet. Analyses of variance (ANOVA) showed only a main effect of time (p < 0.01) and no group or interaction effects (p > 0.05) in the examined parameters. Total and trunk fat mass decreased by 1.81 kg (90%CI: −2.63 to −0.99 kg; p = 0.002) and 1.45 kg (90%CI: −1.95 to −0.94 kg; p < 0.001), respectively, while leg lean mass increased by 0.86 kg (90%CI: 0.63 to 1.08 kg; p < 0.001), following both HIIT protocols. HIIT increased peak fat oxidation (PFO) (from 0.20 ± 0.05 to 0.33 ± 0.08 g/min, p = 0.001), as well as fat oxidation over a wide range of submaximal exercise intensities, and shifted PFO to higher intensity (from 33.6 ± 4.6 to 37.6 ± 6.7% VO2peak, p = 0.039). HIIT, irrespective of protocol, improved VO2peak by 20.0 ± 7.2% (p < 0.001), while blood lactate at various submaximal intensities decreased by 20.6% (p = 0.001). In conclusion, both HIIT protocols were equally effective in improving regional body composition and fat oxidation during exercise in obese men.


2002 ◽  
Vol 75 (1) ◽  
pp. 31-37 ◽  
Author(s):  
Kate P Kerruish ◽  
Janice O'Connor ◽  
Ian RJ Humphries ◽  
Michael R Kohn ◽  
Simon D Clarke ◽  
...  

1984 ◽  
Vol 40 (5) ◽  
pp. 1001-1006 ◽  
Author(s):  
J L Johnston ◽  
L A Leiter ◽  
G N Burrow ◽  
P E Garfinkel ◽  
G H Anderson

2002 ◽  
Vol 92 (4) ◽  
pp. 1611-1618 ◽  
Author(s):  
Bradley C. Nindl ◽  
Charles R. Scoville ◽  
Kathleen M. Sheehan ◽  
Cara D. Leone ◽  
Robert P. Mello

This study evaluated the arm, trunk, and leg for fat mass, lean soft tissue mass, and bone mineral content (BMC) assessed via dual-energy X-ray absorptiometry in a group of age-matched (∼29 yr) men ( n = 57) and women ( n = 63) and determined their relationship to insulin-like growth factor I (IGF-I) and leptin. After analysis of covariance adjustment to control for differences in body mass between genders, the differences that persisted ( P ≤ 0.05) were for lean soft tissue mass of the arm (men: 7.1 kg vs. women: 6.4 kg) and fat mass of the leg (men: 5.3 kg vs. women: 6.8 kg). Men and women had similar ( P ≥ 0.05) values for fat mass of the arms and trunk and lean soft tissue mass of the legs and trunk. Serum IGF-I and insulin-like growth factor binding protein-3 correlated ( P≤ 0.05) with all measures of BMC ( r values ranged from 0.31 to 0.39) and some measures of lean soft tissue mass for women ( r = 0.30) but not men. Leptin correlated ( P≤ 0.05) similarly for measures of fat mass for both genders ( r values ranging from 0.74 to 0.85) and for lean soft tissue mass of the trunk ( r = 0.40) and total body ( r = 0.32) for men and for the arms in women ( r = 0.56). These data demonstrate that 1) the main phenotypic gender differences in body composition are that men have more of their muscle mass in their arms and women have more of their fat mass in their legs and 2) gender differences exist in the relationship between somatotrophic hormones and lean soft tissue mass.


2020 ◽  
Vol 52 (7S) ◽  
pp. 867-867
Author(s):  
Erica Roelofs ◽  
April Bockin ◽  
Tyler A. Bosch ◽  
Christopher W. Bach ◽  
Jonathan M. Oliver ◽  
...  

2017 ◽  
Vol 49 (5S) ◽  
pp. 264-265
Author(s):  
Alexa Suida ◽  
Peter J. Chomentowski ◽  
Amanda J. Salacinski ◽  
Craig Broeder

2004 ◽  
Vol 89 (7) ◽  
pp. 3486-3495 ◽  
Author(s):  
Madhusmita Misra ◽  
Karen K. Miller ◽  
Cecilia Almazan ◽  
Kavitha Ramaswamy ◽  
Avichal Aggarwal ◽  
...  

Abstract Anorexia nervosa (AN) is associated with very low levels of leptin, a cytokine secreted by adipose tissue and known to suppress appetite. Leptin may play a permissive role in onset of puberty and in resumption of gonadal function in conditions of undernutrition. The soluble leptin receptor (sOB-R) is the main leptin binding protein, and the ratio of serum leptin to sOB-R provides a measure of the free leptin index (FLI), which may be a more accurate determinant of leptin function. Determinants of sOB-R and FLI have not been examined in an adolescent population. We examined levels of sOB-R, leptin, and FLI, and body composition and hormonal determinants of these variables in 23 adolescent girls with AN and 21 healthy adolescent girls of comparable maturity prospectively over 1 yr. Measures of insulin resistance and adiponectin were also examined. We determined changes in levels of sOB-R, leptin, and FLI with weight recovery (defined as an increase in body mass index of ≥10%, n = 11), and with resumption of menstrual cycles (n = 13). Girls with AN had significantly higher levels of sOB-R (P = 0.0008) and significantly lower levels of leptin and FLI (P &lt; 0.0001 for both) than healthy controls, and levels of FLI were reduced more than levels of leptin in girls with AN compared with controls. An inverse correlation was noted between levels of leptin and sOB-R for the group as a whole (r = −0.64, P &lt; 0.0001) but not in girls with AN considered alone. The most important predictor of levels of sOB-R was cortisol in the group as a whole (r = 0.61, P &lt; 0.0001) and in girls with AN considered alone (r = 0.66, P = 0.0008). Other independent predictors of sOB-R levels for the entire group were percent body fat (r = −0.44, P = 0.003) and levels of IGF-I (r = −0.37, P = 0.01). The most important predictors of leptin and FLI were body mass index and percent body fat. An inverse relationship was noted between measures of insulin resistance and sOB-R levels, whereas a positive association was noted between these measures and leptin and FLI. Adiponectin values did not differ in girls with AN compared with healthy controls and did not correlate with sOB-R, leptin, or FLI. Weight recovery resulted in significant decreases in levels of the sOB-R (24.7 ± 1.7 to 17.6 ± 1.2 U/ml, P = 0.004), and increases in levels of leptin (4.4 ± 1.0 to 13.7 ± 2.9 μg/liter, P = 0.02). Resumption of menstrual function, but not weight recovery alone, was associated with significant increases in FLI (0.19 ± 0.04 to 0.50 ± 0.09 μg/U × 10−3, P = 0.02). We demonstrate an increase in levels of sOB-R and a decrease in the FLI in adolescent girls with AN, and also demonstrate that cortisol is the most important predictor of levels of sOB-R in this condition. Levels of leptin and FLI, conversely, are primarily predicted by body composition. Weight recovery is associated with a decrease in sOB-R and an increase in leptin. Resumption of menses is associated with significant increases in the FLI, suggesting that free leptin may be an important determinant of menstrual recovery.


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