scholarly journals Hormonal Determinants of Regional Body Composition in Adolescent Girls with Anorexia Nervosa and Controls

2005 ◽  
Vol 90 (5) ◽  
pp. 2580-2587 ◽  
Author(s):  
Madhusmita Misra ◽  
Karen K. Miller ◽  
Cecilia Almazan ◽  
Megan Worley ◽  
David B. Herzog ◽  
...  
Keyword(s):  
Body Composition ◽  
Anorexia Nervosa ◽  
Adolescent Girls ◽  
Regional Body Composition

Comparison of total and regional body composition in adolescent patients with anorexia nervosa and pair-matched controls

1998 ◽  
Vol 3 (4) ◽  
pp. 179-187 ◽  
Author(s):  
Peter Schneider ◽  
J. Biko ◽  
D. Schlamp ◽  
G.-E. Trott ◽  
F. Badura ◽  
...  
Keyword(s):  
Body Composition ◽  
Anorexia Nervosa ◽  
Regional Body Composition ◽  
Adolescent Patients

scholarly journals Hormonal and Body Composition Predictors of Soluble Leptin Receptor, Leptin, and Free Leptin Index in Adolescent Girls with Anorexia Nervosa and Controls and Relation to Insulin Sensitivity

2004 ◽  
Vol 89 (7) ◽  
pp. 3486-3495 ◽  
Author(s):  
Madhusmita Misra ◽  
Karen K. Miller ◽  
Cecilia Almazan ◽  
Kavitha Ramaswamy ◽  
Avichal Aggarwal ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Body Mass Index ◽  
Body Composition ◽  
Anorexia Nervosa ◽  
Body Fat ◽  
Adolescent Girls ◽  
Leptin Receptor ◽  
Percent Body Fat ◽  
Healthy Controls ◽  
Soluble Leptin Receptor

Abstract Anorexia nervosa (AN) is associated with very low levels of leptin, a cytokine secreted by adipose tissue and known to suppress appetite. Leptin may play a permissive role in onset of puberty and in resumption of gonadal function in conditions of undernutrition. The soluble leptin receptor (sOB-R) is the main leptin binding protein, and the ratio of serum leptin to sOB-R provides a measure of the free leptin index (FLI), which may be a more accurate determinant of leptin function. Determinants of sOB-R and FLI have not been examined in an adolescent population. We examined levels of sOB-R, leptin, and FLI, and body composition and hormonal determinants of these variables in 23 adolescent girls with AN and 21 healthy adolescent girls of comparable maturity prospectively over 1 yr. Measures of insulin resistance and adiponectin were also examined. We determined changes in levels of sOB-R, leptin, and FLI with weight recovery (defined as an increase in body mass index of ≥10%, n = 11), and with resumption of menstrual cycles (n = 13). Girls with AN had significantly higher levels of sOB-R (P = 0.0008) and significantly lower levels of leptin and FLI (P < 0.0001 for both) than healthy controls, and levels of FLI were reduced more than levels of leptin in girls with AN compared with controls. An inverse correlation was noted between levels of leptin and sOB-R for the group as a whole (r = −0.64, P < 0.0001) but not in girls with AN considered alone. The most important predictor of levels of sOB-R was cortisol in the group as a whole (r = 0.61, P < 0.0001) and in girls with AN considered alone (r = 0.66, P = 0.0008). Other independent predictors of sOB-R levels for the entire group were percent body fat (r = −0.44, P = 0.003) and levels of IGF-I (r = −0.37, P = 0.01). The most important predictors of leptin and FLI were body mass index and percent body fat. An inverse relationship was noted between measures of insulin resistance and sOB-R levels, whereas a positive association was noted between these measures and leptin and FLI. Adiponectin values did not differ in girls with AN compared with healthy controls and did not correlate with sOB-R, leptin, or FLI. Weight recovery resulted in significant decreases in levels of the sOB-R (24.7 ± 1.7 to 17.6 ± 1.2 U/ml, P = 0.004), and increases in levels of leptin (4.4 ± 1.0 to 13.7 ± 2.9 μg/liter, P = 0.02). Resumption of menstrual function, but not weight recovery alone, was associated with significant increases in FLI (0.19 ± 0.04 to 0.50 ± 0.09 μg/U × 10−3, P = 0.02). We demonstrate an increase in levels of sOB-R and a decrease in the FLI in adolescent girls with AN, and also demonstrate that cortisol is the most important predictor of levels of sOB-R in this condition. Levels of leptin and FLI, conversely, are primarily predicted by body composition. Weight recovery is associated with a decrease in sOB-R and an increase in leptin. Resumption of menses is associated with significant increases in the FLI, suggesting that free leptin may be an important determinant of menstrual recovery.

Secretory dynamics of leptin in adolescent girls with anorexia nervosa and healthy adolescents

2005 ◽  
Vol 289 (3) ◽  
pp. E373-E381 ◽  
Author(s):  
Madhusmita Misra ◽  
Karen K. Miller ◽  
Kelly Kuo ◽  
Kathryn Griffin ◽  
Victoria Stewart ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Body Composition ◽  
Anorexia Nervosa ◽  
Adolescent Girls ◽  
Basal Secretion ◽  
Burst Frequency ◽  
Pulsatile Secretion ◽  
Urine Free Cortisol ◽  
Free Cortisol ◽  
Thyroid Hormone Levels

Leptin, an adipocytokine that suppresses appetite and may regulate neuroendocrine pathways, is low in undernourished states like anorexia nervosa (AN). Although leptin exhibits pulsatility, secretory characteristics have not been well described in adolescents and in AN, and the contribution of hypoleptinemia to increased growth hormone (GH) and cortisol in AN has not been explored. We hypothesized that hypoleptinemia in AN reflects decreased basal and pulsatile secretion and may predict increased GH and cortisol levels. Sampling for leptin, GH, cortisol, and ghrelin was performed every 30 min (from 2000 to 0800) in 23 AN and 21 controls 12–18 yr old, and data were analyzed using Cluster and deconvolution methods. Estradiol, thyroid hormones, and body composition were measured. AN girls had lower pulsatile and total leptin secretion than controls ( P < 0.0001) subsequent to decreased burst mass ( P < 0.0001) and basal secretion ( P = 0.02). Nutritional markers predicted leptin characteristics. In a regression model including BMI, body fat, and ghrelin, leptin independently predicted GH burst interval and frequency. Valley leptin contributed to 56% of the variability in GH burst interval, and basal leptin and fasting ghrelin contributed to 42% of variability in burst frequency. Pulsatile leptin independently predicted urine free cortisol/creatinine (15% of variability). Valley leptin predicted cortisol half-life (22% of variability). Leptin predicted estradiol and thyroid hormone levels. In conclusion, hypoleptinemia in AN is subsequent to decreased basal and pulsatile secretion and nutritionally regulated. Leptin predicts GH and cortisol parameters and with ghrelin predicts GH burst frequency. Low leptin and high ghrelin may be dual stimuli for high GH concentrations in undernutrition.

scholarly journals Regional body composition in adolescents with anorexia nervosa and changes with weight recovery

2003 ◽  
Vol 77 (6) ◽  
pp. 1361-1367 ◽  
Author(s):  
Madhusmita Misra ◽  
Leslie A Soyka ◽  
Karen K Miller ◽  
Steven Grinspoon ◽  
Lynne L Levitsky ◽  
...  
Keyword(s):  
Body Composition ◽  
Anorexia Nervosa ◽  
Regional Body Composition

scholarly journals Effects of School-Based Exercise and Nutrition Intervention on Body Composition and Physical Fitness in Overweight Adolescent Girls

Nutrients ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 238
Author(s):  
Špela Bogataj ◽  
Nebojša Trajković ◽  
Cristina Cadenas-Sanchez ◽  
Vedrana Sember
Keyword(s):  
Body Composition ◽  
Physical Fitness ◽  
Body Fat ◽  
Adolescent Girls ◽  
Nutrition Intervention ◽  
School Based ◽  
Hand Grip ◽  
Overweight Adolescent ◽  
Overweight Adolescent Girls ◽  
Medicine Ball

Regular exercise during school hours is encouraged since childhood obesity has reached epidemic proportions. Moreover, a great majority of adolescents do not meet the recommendations for moderate-to-vigorous physical activity. The present study aimed to determine the effects of school-based high-intensity interval training (HIIT) and nutrition intervention on body composition and physical fitness in overweight adolescent girls. Forty-eight girls were included in the study, of whom 24 (age = 15.5 ± 0.7 years) were randomized to a experimental group (EXP) (HIIT and nutrition intervention school-based program) and 24 (age = 15.7 ± 0.6 years) to a control group (CON) that maintained their usual physical education activities. HIIT consisted of 10 stations of own bodyweight exercise and was done three times per week for eight weeks. Moreover, the EXP participated in the nutrition program led by a nutritionist two times a week. Apart from body composition assessment, participants performed countermovement jump (CMJ), medicine ball throw, hand-grip test, and Yo-Yo Intermittent Recovery Level 1 Test (YYIRT1). A significant effect of group (EXP vs. CON) x time (pre vs. post) interaction was observed for weight [F(1,44) = 7.733; p = 0.008], body mass index [F(1,44) = 5.764; p = 0.020], body fat (in kg) [F(1,44) = 17.850; p < 0.001], and body fat (in %) [F(1,44) = 18.821; p < 0.001]. Moreover, a significant interaction was observed for the medicine ball throw [F(1,44) = 27.016; p < 0.001] and YYIRT1 [F(1,44) = 5.439; p = 0.024]. A significant main effect for time was found for hand grip [F(1,44) = 9.300; p = 0.004] and CMJ [F(1,44) = 12.866; p = 0.001].The present study has demonstrated that just eight weeks school-based HIIT and nutrition intervention, including three sessions a week, can improve body composition and muscular and physical aerobic performance in overweighted adolescent girls.

Bone mineral density and oxidative stress in adolescent girls with anorexia nervosa

2021 ◽  
Author(s):  
Alžbeta Čagalová ◽  
Ľubica Tichá ◽  
Alexandra Gaál Kovalčíková ◽  
Katarína Šebeková ◽  
Ľudmila Podracká
Keyword(s):  
Oxidative Stress ◽  
Bone Mineral Density ◽  
Anorexia Nervosa ◽  
Bone Mineral ◽  
Adolescent Girls ◽  
Mineral Density ◽  
And Oxidative Stress

scholarly journals Effects of Two Workload-Matched High-Intensity Interval Training Protocols on Regional Body Composition and Fat Oxidation in Obese Men

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1096
Author(s):  
Spyridon Tsirigkakis ◽  
George Mastorakos ◽  
Yiannis Koutedakis ◽  
Vassilis Mougios ◽  
Alan M. Nevill ◽  
...  
Keyword(s):  
Body Composition ◽  
High Intensity ◽  
Interval Training ◽  
Fat Oxidation ◽  
Peak Oxygen Uptake ◽  
High Intensity Interval Training ◽  
Randomized Design ◽  
Wide Range ◽  
Regional Body Composition ◽  
High Intensity Interval

The effects of two high-intensity interval training (HIIT) protocols on regional body composition and fat oxidation in men with obesity were compared using a parallel randomized design. Sixteen inactive males (age, 38.9 ± 7.3 years; body fat, 31.8 ± 3.9%; peak oxygen uptake, VO2peak, 30.9 ± 4.1 mL/kg/min; all mean ± SD) were randomly assigned to either HIIT10 (48 × 10 s bouts at 100% of peak power [Wpeak] with 15 s of recovery) or HIIT60 group (8 × 60 s bouts at 100% Wpeak with 90 s of recovery), and subsequently completed eight weeks of training, while maintaining the same diet. Analyses of variance (ANOVA) showed only a main effect of time (p < 0.01) and no group or interaction effects (p > 0.05) in the examined parameters. Total and trunk fat mass decreased by 1.81 kg (90%CI: −2.63 to −0.99 kg; p = 0.002) and 1.45 kg (90%CI: −1.95 to −0.94 kg; p < 0.001), respectively, while leg lean mass increased by 0.86 kg (90%CI: 0.63 to 1.08 kg; p < 0.001), following both HIIT protocols. HIIT increased peak fat oxidation (PFO) (from 0.20 ± 0.05 to 0.33 ± 0.08 g/min, p = 0.001), as well as fat oxidation over a wide range of submaximal exercise intensities, and shifted PFO to higher intensity (from 33.6 ± 4.6 to 37.6 ± 6.7% VO2peak, p = 0.039). HIIT, irrespective of protocol, improved VO2peak by 20.0 ± 7.2% (p < 0.001), while blood lactate at various submaximal intensities decreased by 20.6% (p = 0.001). In conclusion, both HIIT protocols were equally effective in improving regional body composition and fat oxidation during exercise in obese men.

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