scholarly journals Agreement between markers of population iodine status in classifying iodine status of populations: a systematic review

2019 ◽  
Vol 110 (4) ◽  
pp. 949-958 ◽  
Author(s):  
Molla Mesele Wassie ◽  
Philippa Middleton ◽  
Shao Jia Zhou
Keyword(s):  
Systematic Review ◽  
Urinary Iodine ◽  
Iodine Concentration ◽  
Thyroid Stimulating Hormone ◽  
School Age Children ◽  
Urinary Iodine Concentration ◽  
School Age ◽  
Iodine Status ◽  
Goiter Prevalence ◽  
Reference Markers

ABSTRACT Background Population iodine deficiency is indicated by >3% of the population with newborn thyroid-stimulating hormone (TSH) concentration >5 mIU/L, median urinary iodine concentration (MUIC) <100 µg/L, or >5% prevalence of goiter in school-age children. However, the agreement between these population markers has not been systematically investigated. Objective To assess the agreement between TSH, MUIC, and goiter as markers of population iodine status. Methods We performed a systematic search for studies published on PubMed, Scopus, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Embase, and PsycINFO up to 29 October, 2018. Studies assessing iodine status in the population using the TSH marker and either MUIC or goiter prevalence in school-age children were included. The agreement between markers in classifying iodine status of the population was assessed. The sensitivity and specificity of the TSH marker was determined against MUIC and goiter prevalence as the reference markers. Results Of 17,435 records identified by the search strategy, 57 eligible studies were included in the review. The agreement between markers in classifying the iodine status of populations into the same category was 65% for TSH and MUIC, and 83% for TSH and goiter prevalence. The TSH marker had a sensitivity of 0.75 and specificity of 0.53 when compared with MUIC, and 0.86 and 0.50 when compared with goiter prevalence. Conclusions The TSH marker has a better agreement with goiter prevalence than MUIC when classifying the iodine status of populations. Re-evaluation of the current criteria for classifying the iodine status of populations using the TSH marker is warranted. This systematic review was registered at PROSPERO (http://www.crd.york.ac.uk/prospero/) as CRD42018091247.

scholarly journals Iodine status of school age children in the two hilly districts Dhankuta and Tehrathum of Eastern Nepal

2013 ◽  
Vol 1 (1) ◽  
pp. 38-41
Author(s):  
AK Nepal ◽  
S Gautam ◽  
S Khatiwada ◽  
PR Shakya ◽  
B Gelal ◽  
...  
Keyword(s):  
School Children ◽  
Urinary Iodine ◽  
Iodine Concentration ◽  
Cross Sectional Study ◽  
School Age Children ◽  
Urinary Iodine Concentration ◽  
Population Parameter ◽  
School Age ◽  
Cross Sectional ◽  
Iodine Status

Background: Iodine deficiency remains a significant health problem in developing countries, including Nepal.   Objective: This study was conducted to measure the iodine status of school children in two districts Dhankuta and Tehrathum of Eastern Nepal by estimating median urinary iodine concentration (UIC) as a population parameter in the school children. Materials and Methods: This cross-sectional study was conducted from August 2010 to July 2011 in school children (6-12 years of age) of two hilly districts of Eastern Nepal, Dhankuta and Tehrathum. A total of 154 school age children from the two districts were chosen for the study after obtaining written consent from their guardians and school authority. UIC was estimated in these school children by ammonium persulphate digestion microplate method. Results: Among the school age children selected for the study median inter-quartile range (IQR) of urinary iodine in Dhankuta (n=63) and Tehrathum (n=91) districts were 214.04 (126.44; 323.0) μg/L and 252.34 (161.81; 301.63) μg/L. No significant differences were observed between the median UIC of these two districts (p=0.235). Among the school children in Dhankuta districts 2(3.2%) were severely deficient, 4(6.3%) were moderately deficient and 6(9.5%) were mildly deficient. In Tehrathum district 2(2.2%) were moderately deficient and 5(5.5%) were mildly deficient. Conclusion: The present study showed improved iodine status with optimal levels of median urinary iodine concentration in the two districts, Dhankuta and Tehrathum of Eastern Nepal. Regular monitoring of population median urinary iodine concentration is recommended for sustainable optimal iodine nutrition.DOI: http://dx.doi.org/10.3126/stcj.v1i1.7986 Sunsari Technical College Journal Vol.1(1) 2012 38-41

scholarly journals Iodine Status of Women and Infants in Russia: A Systematic Review

2020 ◽  
Vol 17 (22) ◽  
pp. 8346
Author(s):  
Rimma Korobitsyna ◽  
Andrey Aksenov ◽  
Tatiana Sorokina ◽  
Anna Trofimova ◽  
Nikita Sobolev ◽  
...  
Keyword(s):  
Public Health ◽  
Systematic Review ◽  
Urinary Iodine ◽  
Public Health Problem ◽  
Iodine Concentration ◽  
Urinary Iodine Concentration ◽  
Iodine Status ◽  
Available Information ◽  
Substantial Heterogeneity ◽  
Status Of Women

This systematic review presents a critical synthesis of the available information on the iodine status among women and infants in Russia. Literature search was performed in accordance with PRISMA guidelines using PubMed, Scopus Web of Science databases as well as eLIBRARY—the Russian national source. Altogether, 277 papers were identified and 19 of them were eligible for the review. The data on median urinary iodine concentration (UIC) in women and infants from 25 Russian regions were presented. A substantial variability in UIC across the country with no clear geographical pattern was observed. Despite substantial heterogeneity in research methodology and data presentation the results suggest that the iodine status among pregnant women and infants in Russia is below the recommended levels. Our findings demonstrate that iodine deficiency is a re-emerging public health problem in Russia. Urgent public health measures on national, regional and individual levels are warranted.

scholarly journals Iodine Status and Thyroid Function in a Group of Seaweed Consumers in Norway

Nutrients ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3483
Author(s):  
Inger Aakre ◽  
Lidunn Tveito Evensen ◽  
Marian Kjellevold ◽  
Lisbeth Dahl ◽  
Sigrun Henjum ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Urinary Iodine ◽  
Iodine Content ◽  
Iodine Concentration ◽  
Iodine Intake ◽  
Thyroid Stimulating Hormone ◽  
Urinary Iodine Concentration ◽  
Free Triiodothyronine ◽  
Iodine Status ◽  
Excessive Iodine

Seaweeds, or macroalgae, may be a good dietary iodine source but also a source of excessive iodine intake. The main aim in this study was to describe the iodine status and thyroid function in a group of macroalgae consumers. Two urine samples were collected from each participant (n = 44) to measure urinary iodine concentration (UIC) after habitual consumption of seaweed. Serum thyroid stimulating hormone (TSH), free thyroxine (fT4), free triiodothyronine (fT3), and peroxidase autoantibody (TPOAb), were measured in a subgroup (n = 19). A food frequency questionnaire and an iodine-specific 24 h recall were used to assess iodine intake and macroalgae consumption. The median (p25–p75) UIC was 1200 (370–2850) μg/L. Median (p25–p75) estimated dietary iodine intake, excluding macroalgae, was 110 (78–680) μg/day, indicating that seaweed was the major contributor to the iodine intake. TSH levels were within the reference values, but higher than in other comparable population groups. One third of the participants used seaweeds daily, and sugar kelp, winged kelp, dulse and laver were the most common species. Labelling of iodine content was lacking for a large share of the products consumed. This study found excessive iodine status in macroalgae consumers after intake of dietary seaweeds. Including macroalgae in the diet may give excessive iodine exposure, and consumers should be made aware of the risk associated with inclusion of macroalgae in their diet.

scholarly journals Iodine Nutritional Status and Related Factors among Chinese School-Age Children in Three Different Areas: A Cross-Sectional Study

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1404
Author(s):  
Xiaoyun Shan ◽  
Changqing Liu ◽  
Xiaoyan Luo ◽  
Yan Zou ◽  
Lichun Huang ◽  
...  
Keyword(s):  
Vitamin A ◽  
Nutritional Status ◽  
Iodine Deficiency ◽  
Urinary Iodine ◽  
Thyroid Stimulating Hormone ◽  
School Age Children ◽  
Urinary Iodine Concentration ◽  
School Age ◽  
Related Factors ◽  
Cross Sectional

We evaluated the iodine nutritional status and related factors among school-age children based on the 2016 National Nutrition and Health Surveillance of Children and Lactating Women; 3808 children from Hebei, Guangxi, and Zhejiang province were included in the study. Urinary iodine concentration (UIC), thyroid-stimulating hormone (TSH), body mass index (BMI), vitamin A (VA), and vitamin D (VD) were measured. The abnormal rate of UIC and TSH were assessed. Relationships between UIC/TSH and the possible factors were analyzed. The overall median UIC was 185.14 µg/L, and the median UIC of children aged 8–10 was 164.60 µg/L. Prevalence of iodine deficiency and excess was 13.84% and 14.36%, respectively, and 12.87% of children showed TSH excess. UIC, as well as the abnormal rates of iodine deficiency (ID) and TSH, were significantly different among the three provinces. The median UICs and excess rates increased with age, reaching 211.45 µg/L and 21.35% at age of 14~, while TSH showed the opposite trend. Overweight children tended to have lower UIC and higher TSH. Higher UIC and TSH were found in VA sufficient group (p < 0.01). Further, the VD deficient group had a higher TSH compared to the sufficient group (p < 0.01). Moreover, UI and TSH distribution was obviously different among different vitamin A/D status (p < 0.05). Although the median UIC of school-age children was optimal, there were pockets of inadequate and excessive UI in the three provinces. Compared to the national IDD monitoring results in 2014, the iodine nutritional status of children was greatly improved. Considerations of region, age, BMI, VA, or VD are needed in the future iodine evaluation and surveillance.

scholarly journals Excess urinary iodine concentration and thyroid dysfunction among school age children of eastern Nepal: a matter of concern

2019 ◽  
Vol 12 (1) ◽  
Author(s):  
Man Kumar Tamang ◽  
Basanta Gelal ◽  
Binaya Tamang ◽  
Madhab Lamsal ◽  
David Brodie ◽  
...  
Keyword(s):  
Thyroid Dysfunction ◽  
Urinary Iodine ◽  
Iodine Concentration ◽  
School Age Children ◽  
Urinary Iodine Concentration ◽  
School Age

scholarly journals THE SITUATION OF URINARY IODINE CONCENTRATION (UIC) AMONG SCHOOL AGE CHILDREN, WOMEN AT REPRODUCTIVE AGE AND PREGNANT WOMEN IN INDONESIA: THE ANALYSIS OF RISKESDAS 2013

2017 ◽  
Vol 39 (1) ◽  
pp. 49
Author(s):  
Djoko Kartono ◽  
Atmarita Atmarita ◽  
Abas B Jahari ◽  
Soekirman Soekirman ◽  
Doddy Izwardy
Keyword(s):  
Pregnant Women ◽  
Iodine Deficiency ◽  
Urinary Iodine ◽  
Iodine Concentration ◽  
Iodized Salt ◽  
Reproductive Age ◽  
School Age Children ◽  
Urinary Iodine Concentration ◽  
Iodine Status ◽  
Iodine Level

Iodine Deficiency Disorders (IDD) are the leading cause of goiter, cretinism, developmental delays and other health problems. Iodine deficiency is an important public health issue as it is a preventable cause of intellectual disability. While elimination of iodine deficiency is imperative, it should be noted that excessive intake of iodine can also lead to adverse health effects. This paper analyzed the iodine status using median urinary iodine concentration (MUIC) of school age children (SAC), women of reproductive age (WRA), and pregnant women (PW) who live in the same household from Riskesdas 2013. The total number of households included in the analysis was 13,811 households, from which 6,149 SAC (aged 6 – 12 years), 13,218 WRA (aged 15-49 years), and 578 PW (aged 15-49 years) were enumerated. The national MUIC of SAC, WRA and PWwas  in the normal range indicated that  the iodine status was adequate using WHO epidemiological criteria. Iodine status in some sub-populations indicated deficiency, however, in terms of geographic characteristics people who live in the urban has better iodine status compared to rural areas. Similarly, populations in richer economic quintiles had better iodine status. Only pregnant women in the 1st and 2nd quintile were deficient. Almost all regions in Indonesia showed the MUIC was in the normal adequate range, except NTT-NTB, Maluku-Papua, and East Java for pregnant women who tend to have lower MUIC (<150 µg/L). The status of iodized salt at the household was detected using both Rapid Test Kit/RTK as well as Titration. The result demonstrated a strong association between salt iodine level and iodine status. The MUIC for all three groups were lower when the iodine level in salt was lower, then increased when the levels of iodine content in salt increased. The iodine status of pregnant women consuming non-iodized salt was inadequate. The detrimental effect of iodine deficiency on the mental and physical development of children as well as on the women of reproductive age has been recognized. Indonesia still needs the salt iodization program to keep the iodine status in the normal range. In particular coverage with adequately iodized salt needs to be improved in order to improve the iodine status of pregnant women. For the prevention of Iodine disorders (insufficient), monitoring should be undertaken in regular basis to assess the MUIC, especially for pregnant women.

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