The Uterine Plexiform Lesions Revisited

2020 ◽  
Vol 154 (2) ◽  
pp. 178-189 ◽  
Author(s):  
Georgia Karpathiou ◽  
Alexandra Papoudou-Bai ◽  
Alix Clemenson ◽  
Celine Chauleur ◽  
Michel Peoc’h
Keyword(s):  
Smooth Muscle ◽  
Incidental Findings ◽  
Recent Literature ◽  
English Literature ◽  
Intravenous Leiomyomatosis ◽  
Benign Lesions ◽  
Historical Aspects ◽  
Plexiform Lesions ◽  
Disseminated Peritoneal Leiomyomatosis ◽  
Meta Analyses

Abstract Objectives Uterine lesions with plexiform morphology are uncommon lesions with debated histogenesis. Despite being an incidental and usually benign finding (plexiform tumorlet), some cases can pose diagnostic problems. Their paucity in the recent literature adds to these difficulties and often causes ambiguities. The objective of this study is to systematically review published cases to highlight the historical aspects of their recognition, reappraising their morphology, histogenesis, and differential diagnosis. Methods English literature is reviewed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, and 32 reports are analyzed. Results Most cases are reported in the fourth to sixth decades. In most cases (66.7%), plexiform lesions are incidental findings while 33.3% of cases have been the chief pathology. Size varies from 0.5 to 195 mm. Plexiform foci were solitary in 78.2% cases and multiple in 21.8%. In 67.8% of cases, the lesions are reported as myometrial, while 32.2% are arising from endometrial stroma. Immunohistochemistry shows smooth muscle and no sex cord marker expression. They are usually benign lesions, but worrisome features include plexiform morphology in disseminated peritoneal leiomyomatosis, intravenous leiomyomatosis, and diffuse uterine leiomyomatosis. Conclusions Plexiform lesions represent a diverse pathology varying from epithelioid leiomyomas to epithelioid smooth muscle metaplasia of endometrial type of stroma.

Historical aspects of video endoscopic surgery of the lumbar spine

2021 ◽  
Vol 18 (1) ◽  
pp. 70-77
Author(s):  
M. N. Kravtsov
Keyword(s):  
Lumbar Spine ◽  
Literature Review ◽  
Endoscopic Surgery ◽  
English Literature ◽  
Surgical Interventions ◽  
Historical Aspects ◽  
Endoscopic Techniques ◽  
History Of

The literature review is devoted to the history of the development of endoscopic surgery of the lumbar spine: from open surgical interventions and puncture procedures – to percutaneous intracanal endoscopic operations, combining interventional and video endoscopic technologies and referred to in the English literature as “full-endoscopy”. The article also touches upon the historical aspects of fibroendoscopic and laparoscopic interventions on the lumbar spine. In conclusion, the principle of classification of endoscopic techniques is proposed.

scholarly journals Acquired smooth muscle hamartoma: A case report on the lower extremity with hidrosis

2019 ◽  
Vol 7 ◽  
pp. 2050313X1989383
Author(s):  
Malika A Ladha ◽  
Todd Remington
Keyword(s):  
Smooth Muscle ◽  
Case Report ◽  
Lower Extremity ◽  
Smooth Muscle Cells ◽  
English Literature ◽  
Surgical Excision ◽  
Muscle Cells ◽  
Clinical Spectrum ◽  
Rare Entity ◽  
First Case

Smooth muscle hamartomas are benign dermal proliferations of smooth muscle cells. Smooth muscle hamartomas are sub-divided into congenital or acquired; the latter is a rare entity with less than 20 cases being reported in the English literature. Most often asymptomatic, acquired smooth muscle hamartomas follow an indolent course. Treatment in the form of surgical excision can be utilized for symptomatic or cosmetic purposes. Here, we report the first case of an acquired smooth muscle hamartomas of the shin which also uniquely presented with hidrosis. This case highlights the varied clinical spectrum of acquired smooth muscle hamartomas.

Predictors for place of death among children:A systematic review and meta-analyses of recent literature

2020 ◽  
Vol 179 (8) ◽  
pp. 1227-1238
Author(s):  
Sanne Lausen Wolff ◽  
Christian Fynbo Christiansen ◽  
Mette Kjaergaard Nielsen ◽  
Soeren Paaske Johnsen ◽  
Henrik Schroeder ◽  
...  
Keyword(s):  
Systematic Review ◽  
Recent Literature ◽  
Place Of Death ◽  
Meta Analyses

scholarly journals Intraplacental Leiomyoma in a Case of Second-Trimester Intrauterine Fetal Demise

2020 ◽  
Vol 13 ◽  
pp. 2632010X2092832
Author(s):  
Selene C Koo ◽  
Fang Bu
Keyword(s):  
Smooth Muscle ◽  
Umbilical Cord ◽  
Incidental Findings ◽  
Adverse Outcome ◽  
Implantation Site ◽  
Rare Tumor ◽  
Second Trimester ◽  
Histological Findings ◽  
Fetal Demise ◽  
Intrauterine Fetal Demise

Intraplacental leiomyomas are extremely rare and are generally incidental findings in term placentas. We present the first reported case of a placental leiomyoma associated with preterm intrauterine fetal demise, with histological findings providing the cause of adverse outcome. This was an intrauterine fetal demise detected at 26 weeks gestation with a placental finding of a 2.8-cm leiomyoma. Histological findings in the placenta and fetus were consistent with intrauterine fetal demise of weeks. The umbilical cord was markedly hypercoiled, with 6 twists per 10 cm. Features of maternal vascular malperfusion were evident in the placenta, including villous hypermaturity, an infarct adjacent to the leiomyoma, and retention of smooth muscle in spiral arterioles within the decidua overlying the leiomyoma. Implantation-site trophoblasts invaded into the leiomyoma and the overlying decidua. We hypothesize that incorporation of the leiomyoma into the placenta contributed to fetal demise due to disordered placental implantation, implying that these tumors may not be as benign and incidental as previously described. The finding of implantation-site changes in the leiomyoma may also suggest a potential cause for this rare tumor.

Plexiform-like lesions and increased tissue factor expression in a rat model of severe pulmonary arterial hypertension

2007 ◽  
Vol 293 (3) ◽  
pp. L583-L590 ◽  
Author(s):  
R. James White ◽  
David F. Meoli ◽  
Robert F. Swarthout ◽  
Dara Y. Kallop ◽  
Irfan I. Galaria ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Tissue Factor ◽  
Human Disease ◽  
Muscle Hypertrophy ◽  
Sham Operation ◽  
Plexiform Lesions ◽  
Pulmonary Arterial ◽  
Severe Pulmonary Arterial Hypertension

Severe pulmonary arterial hypertension (PAH) occurs in idiopathic form and in association with diverse diseases. The pathological hallmarks are distal smooth muscle hypertrophy, obliteration of small pulmonary arteriole lumens, and disorganized cellular proliferation in plexiform lesions. In situ thrombosis is also observed. A detailed understanding of the disease progression has been hampered by the absence of an animal model bearing all the pathological features of human disease. To create a model with these characteristics, we gave young (200-g) rats monocrotaline 1 wk following left pneumonectomy; controls with vehicle treatment or sham operation were also studied. In experimental rats, pulmonary arteries had distal smooth muscle hypertrophy and proliferative perivascular lesions. The lesions had a plexiform appearance, occurred early in disease development, and were composed of cells expressing endothelial antigens. Three-dimensional microangiography revealed severe vascular pruning and disorganized vascular networks. We found that expression of tissue factor (TF), the membrane glycoprotein that initiates coagulation, facilitates angiogenesis, and mediates arterial injury in the systemic circulation, was increased in the pulmonary arterioles and plexiform-like lesions of the rats. TF was also heavily expressed in the vessels and plexiform lesions of humans with pulmonary arterial hypertension. We conclude that plexiform-like lesions can be reproduced in rats, and this model will facilitate experiments to address controversies about the role of these lesions in PAH. Increased TF expression may contribute to the prothrombotic diathesis and vascular cell proliferation typical of human disease.

Epstein–Barr virus-associated smooth muscle tumour mimicking bilateral vocal process granuloma

2007 ◽  
Vol 122 (1) ◽  
pp. 100-104 ◽  
Author(s):  
E C Gan ◽  
D P C Lau ◽  
K L Chuah
Keyword(s):  
Smooth Muscle ◽  
Epstein Barr Virus ◽  
English Literature ◽  
High Dose ◽  
Smooth Muscle Tumour ◽  
Barr Virus ◽  
Vocal Process ◽  
Epstein Barr ◽  
Laser Excision ◽  
End Stage

AbstractA case is presented of a 36-year-old Chinese woman with a renal transplant for end-stage renal failure due to Goodpasture's syndrome. She presented with a year's history of throat discomfort and acid regurgitation into her throat. Videolaryngoscopy revealed bilateral vocal process granuloma, presumed to be due to gastroesophageal reflux. A four-week course of high dose omeprazole was prescribed. On follow up a month later, the granulomas had enlarged, and laser excision was undertaken. Histological and immunohistochemical staining was consistent with Epstein–Barr virus-associated smooth muscle tumour. This is believed to be the first reported case in the English literature of such a tumour affecting the vocal process. The aim of this paper is to present the pathogenesis, clinical behaviour and treatment of Epstein–Barr virus-associated smooth muscle tumour, and to review the literature concerning the differential diagnosis of polypoid vocal process lesions.

scholarly journals Intravenous Leiomyomatosis with Extension to the Heart Associated with Disseminated Peritoneal Leiomyomatosis

2016 ◽  
Vol 91 (2) ◽  
pp. 185-190
Author(s):  
Young-Lee Jung ◽  
Rak-Kyeong Choi ◽  
Moon-Yong Eom ◽  
Hyun-A Cho ◽  
Woong Choi ◽  
...  
Keyword(s):  
Intravenous Leiomyomatosis ◽  
Disseminated Peritoneal Leiomyomatosis

scholarly journals Disseminated peritoneal leiomyomatosis: an unusual presentation of intra-abdominal lesion mimicking disseminated malignancy

2020 ◽  
Author(s):  
Sweta Soni ◽  
Puneet Pareek ◽  
Satya Narayan
Keyword(s):  
Smooth Muscle ◽  
Treatment Guidelines ◽  
Careful Consideration ◽  
Reproductive Age ◽  
Unusual Presentation ◽  
Smooth Muscle Tumors ◽  
Standard Treatment Guidelines ◽  
Disseminated Peritoneal Leiomyomatosis ◽  
Primary Neoplasms ◽  
High Index Of Suspicion

Leiomyoma are commonly seen as benign smooth muscle tumors of the uterus. Smooth muscle tumors with unusual growth pattern are rare and include 3 primary neoplasms: intravenous leiomyomatosis (IVL), benign metastasizing leiomyoma (BML) and disseminated peritoneal leiomyomatosis (DPL). DPL is a rare benign disease, often giving the appearance of metastatic ovarian or peritoneal carcinoma. It is a disease that predominately affects women at their reproductive age. The risk of malignant transformation is 2-5%. There are no standard treatment guidelines for the management of the DPL. The unusual presentation of the disease delays the diagnosis or is often misdiagnosed and thus over treated, which may lead to increased morbidity and mortality. Therefore careful consideration and high index of suspicion is required for the proper management of such cases.

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