Multiple Pulmonary Pleomorphic Adenomas of Unknown Primary

2020 ◽  
Vol 154 (Supplement_1) ◽  
pp. S38-S39
Author(s):  
X Liu ◽  
W Miller
Keyword(s):  
Ct Scan ◽  
Salivary Glands ◽  
Lower Lobe ◽  
Unknown Primary ◽  
Benign Tumors ◽  
Low Grade ◽  
Eosinophilic Cytoplasm ◽  
Pleomorphic Adenomas ◽  
Multiple Primary ◽  
History Of

Abstract Introduction/Objective The most common site of pleomorphic adenomas (PAs) is salivary glands, which behave as benign tumors and rarely metastasize. Primary PAs in lungs are exceedingly rare. We report a case of multiple PAs in lungs with an inconclusive origin. Methods A 65-year-old woman had a two-year history of numerous scattered bilateral well-circumscribed pulmonary nodules measuring up to 2.1 cm. She had no prior history of smoking, asbestos exposure and salivary gland diseases, and denied any symptoms. The latest chest computed tomography (CT) scan showed the two largest lower lobe nodules had mildly increased in size compared to two years before. The patient then underwent wedge resections. Results Grossly, the wedge resection specimens showed multiple well-circumscribed, pale tan, firm nodules. Microscopically, the nodules comprised cytologically bland nests of polygonal to plasmacytoid cells with eosinophilic cytoplasm, variably set in a myxoid matrix. Immunohistochemical stains demonstrated that the cells were positive for AE-1/AE-3, S-100, bcl-2 and SOX-10, and negative for chromogranin, smooth muscle actin, p63, calponin, PAX-8, CD34, CD31, HMB-45, melan-A, HHF-35, GATA-3, GFAP and RCC marker; TTF-1 highlighted entrapped pulmonary epithelium but the tumor cells were negative. These findings might suggest metastatic low grade PA from salivary glands. However, the patient’s follow-up examination by an otolaryngologist was normal; the CT scan of her chest and abdomen did not show any remarkable findings other than her lung nodules. Conclusion To our knowledge, this is the first reported case of multiple pulmonary PAs without a preceding primary. It has raised questions about the pathogenesis of multiple PAs in lungs. Could PA present as multiple primary nodules in lungs? Could one primary pulmonary PA generate multiple satellite nodules in lungs? Do multiple primary pulmonary PAs have a different IHC profile than that of a single primary pulmonary PA? More research is needed.

scholarly journals Successful Bronchoscopic Cryorecanalization in a Case of Endobronchial Lipoma

2011 ◽  
Vol 2011 ◽  
pp. 1-3 ◽  
Author(s):  
B. Lamprecht ◽  
G. Hutarew ◽  
P. Porsch ◽  
B. Wegleitner ◽  
M. Studnicka
Keyword(s):  
Airway Obstruction ◽  
Lower Lobe ◽  
Rigid Bronchoscopy ◽  
Benign Tumors ◽  
Histopathological Diagnosis ◽  
Heavy Smoking ◽  
History Of ◽  
The Right

Endobronchial lipomas are rare benign tumors; less than 150 cases have been reported so far. Bronchial occlusion usually leads to a misdiagnosis of asthma/COPD or malignancy. We report the case of a 67-year-old man with a history of heavy smoking (100 pack years), dyspnea on exertion, cough, and malaise who was treated for pneumonia for three weeks. Due to nonresolving atelectasis of the superior segment of the right lower lobe, a malignant endobronchial tumor was suspected. Rigid bronchoscopy with cryorecanalization led to both the definite histopathological diagnosis of endobronchial lipoma and the reopening of an endoluminal airway obstruction during one procedure.

scholarly journals Rasmussen's Aneurysm Associate With Pulmonary Artery Vascular Malformation Presented With Haemoptysis

KYAMC Journal ◽  
2019 ◽  
Vol 10 (3) ◽  
pp. 168-170
Author(s):  
Khaleda Parvin Rekha ◽  
Umme Iffat Siddiqua ◽  
Md Mofazzal Sharif ◽  
Md Musharraf Husain ◽  
Mohammad Abdus Salam
Keyword(s):  
Pulmonary Artery ◽  
Ct Scan ◽  
Vascular Malformation ◽  
Left Lung ◽  
Lower Lobe ◽  
Low Grade ◽  
Imaging Department ◽  
Increased Risk ◽  
Risk Of Rupture ◽  
Contrast Ct

Rasmussen's aneurysm is an inflammatory pseudo-aneurysmal dilatation of a branch of pulmonary artery associated with a cavitary lung lesion. Like any aneurysm, a Rasmussen's aneurysm is at increased risk of rupture and bleeding into the lungs. A 52 years old male presented with low-grade fever and haemoptysis, chest x-ray revealed a well margined nodular shadow with calcifications in mid zone of left lung associated with ipsilateral upper zone fibrosis and bronchiectasis. The patient had past history of pulmonary tuberculosis eight years back. For characterization of left pulmonary nodule the patient was referred to radiology and Imaging department and contrast CT scan of chest was done. Contrast CT scan of chest with reformat MIP pulmonary angiogram revealed a small pulmonary artery vascular malformation in lateral basal segment of lower lobe of left lung associated with left upper lobar cavitating lesion with fibrosis, traction bronchiectasis and Rasmussen's aneurysm arising from upper lobar apical segmental pulmonary artery. Early surgical or angiographic interventions with endovascular embolization are recommended once it be clearly diagnosed. KYAMC Journal Vol. 10, No.-3, October 2019, Page 168-170

scholarly journals Polymorphous Low Grade Adenocarcinoma of the Parotid Gland. Cytological, Histological and Immunohistochemical Features and Review of the Literature

2004 ◽  
Vol 47 (1) ◽  
pp. 3-6 ◽  
Author(s):  
Demetrio Tamiolakis ◽  
Vasilios Thomaidis ◽  
Ioannis Tsamis ◽  
Eleni Kariki ◽  
Athanasia Kotini ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Salivary Glands ◽  
Clinical Findings ◽  
Low Grade ◽  
Major Salivary Gland ◽  
Histologic Diagnosis ◽  
Moderate Amount ◽  
Neck Tumors ◽  
Eosinophilic Cytoplasm ◽  
Monomorphic Adenoma

Aim: Polymorphous low grade adenocarcinoma of the salivary glands (PLGA) is a low grade neoplasm that predominantly occurs in the minor salivary glands. In this site is amenable to biopsy and histologic diagnosis. However, experience with cytological findings in these tumors is limited. We describe the cytology of this entity. Experimental design: Touch imprint cytology of a primary parotid PLGA is specified and correlated with histology. Results: Smears were hypercellular showing branching papillae, sheets and clusters of uniform cells with bland nuclei, dispersed chromatin and no nucleoli. The cells had a scant to moderate amount of eosinophilic cytoplasm. They formed tubular structures containing hyaline globules. Conclusions. The cytologic differential diagnosis of PLGA includes adenoid cystic carcinoma, pleomorphic adenoma, and monomorphic adenoma. PLGA should be considered in the differential diagnosis of head and neck tumors, where the cytology suggests on of the above mentioned tumors, even when the clinical findings (involvement of a major salivary gland, lymph node metastasis) is not typical of PLGA.

scholarly journals TUMORS AND TUMOR-LIKE LESIONS OF THE SALIVARY GLANDS: MORPHOLOGICAL CHARACTERISTICS OF THE SURGICAL MATERIAL

2021 ◽  
Vol 74 (4) ◽  
pp. 929-933
Author(s):  
Igor S. Brodetskyi ◽  
Vladislav A. Malanchuk ◽  
Bogdan V. Sorokin ◽  
Mykhailo S. Myroshnychenko ◽  
Yuliya I. Beketova ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Connective Tissue ◽  
Salivary Glands ◽  
Tumor Invasion ◽  
Genetic Research ◽  
Morphological Characteristics ◽  
Benign Tumors ◽  
Clinical Hospital ◽  
Pleomorphic Adenomas ◽  
Tumor Like Lesions

The aim is to give a morphological characteristic of tumors and tumor-like lesions of the salivary glands in the course of a comprehensive analysis of the surgical material. Materials and methods: The study used surgical material from 67 patients with various pathologies of the salivary glands. The patients were treated at Kyiv City Clinical Hospital No. 12 (Ukraine, Kiev) from 2014 to 2018. The resulting material was fixed in a 10% solution of neutral formalin (pH 7.4) for 24-48 hours, carried out according to the generally accepted technique and embedded in paraffin. Serial sections 2 μm thick were made from paraffin blocks and stained with hematoxylin and eosin. Microspecimens were studied, using Olympus BX-41 microscope (Japan). Results: A comprehensive morphological study of the surgical material of patients with salivary gland pathology undergoing treatment at Kyiv City Clinical Hospital No. 12 (Ukraine, Kiev) for the period from 2014 to 2018 revealed benign tumors and tumor-like lesions of these glands. Pleomorphic adenomas and adenolymphomas represented benign tumors of the salivary glands, while cysts represented tumor-like lesions. Different ratios of parenchymal and stromal components characterized pleomorphic adenomas of the salivary glands. On this basis, we identified three tumor variants (mesenchymal (15 cases, 50.0 %); mixed or classic (10 cases, 33.3 %); epithelial (5 cases, 16.7 %)). A characteristic microscopic feature of salivary gland adenolymphomas was a pronounced predominance of the parenchyma over the stroma. A well-defined wall, represented by connective tissue fibers and epithelial lining, characterized the cysts of the salivary glands. The connective tissue capsule separating the tumor tissue from the intact tissue of the salivary gland was clearly pronounced in adenolymphomas, and in pleomorphic adenomas it could be clearly expressed, intact, with tumor invasion or absent. In mesenchymal and mixed variants of pleomorphic adenomas, in comparison with the epithelial variant, there was a frequent tumor invasion of the capsule, thinning of the capsule or its absence. Conclusions: Morphological examination of the surgical material allows us to diagnose tumors (pleomorphic adenomas and adenolymphomas) and non-tumor lesions (cysts) of the salivary glands. This, of course, is of great therapeutic, diagnostic and prognostic value. Among the identified pathology of the salivary glands, pleomorphic adenomas cause certain difficulties in morphological diagnosis due to their structural diversity and heterogeneity, sometimes requiring morphometric, immunohistochemical or genetic research.

Pleomorphic Adenoma of Palate – A Case Report and Review of Literature

2020 ◽  
Author(s):  
Sameer Kaura
Keyword(s):  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Minor Salivary Gland ◽  
Surgical Excision ◽  
Review Of Literature ◽  
Common Site ◽  
Salivary Gland Tumours ◽  
Pleomorphic Adenomas ◽  
Risk Of Malignancy ◽  
History Of

10% of pleomorphic adenomas occur in the minor salivary glands with the palate being the most common site. Pleomorphic adenomas account for the majority of palatal tumours; however, minor salivary gland tumours have a higher risk of malignancy compared to tumours of the major salivary glands, so definite diagnostic evaluation should be executed. A case of 26-year-old man with a longstanding history of a soft palate pleomorphic adenoma which required excision under general anaesthetia We discuss the appropriate preoperative investigations, operative technique for surgical excision, histopathologic interpretation for this patient and brief review of literature for pleomorphic adenoma.

scholarly journals Pleomorphic adenoma of the nasal cavity- an unusual presentation

2016 ◽  
Vol 3 (1) ◽  
pp. 162
Author(s):  
Archana Arora ◽  
Karan Sharma
Keyword(s):  
Nasal Cavity ◽  
Salivary Glands ◽  
Pleomorphic Adenoma ◽  
Nasal Septum ◽  
Histopathological Examination ◽  
Computed Tomographic ◽  
Common Benign Tumor ◽  
Pleomorphic Adenomas ◽  
History Of ◽  
The Right

<p class="abstract">Pleomorphic adenomas (mixed tumors) are the most common benign tumor of the major salivary glands. In addition, they may also occur in the minor salivary glands of the hard and soft palate. Intranasal pleomorphic adenomas are unusual. We report a rare case of large sized pleomorphic adenoma arising from the nasal septum. A 42-year-old man presented with a 3 month history of multiple episodes of nasal bleeding and obstruction on right side of nose. On examination we found a non-tender firm mass extending upto the nasal vestibule which bled on probing. Computed tomographic scans revealed a mass in the right anterior nasal cavity and spur on left side. Paranasal sinuses, posterior choanae and nasopharynx were normal. An intranasal endoscopic approach was used to achieve a wide local resection along with coagulation of base and spurectomy on the left side. The mass was 2.5×2.0 cm with a broad based attachement of 1.0 cm on the nasal septum. The microscopic finding showed a lobular and duct-like structures consisting of a loose chondromyxoid stroma suggestive of a pleomorphic adenoma. Large sized nasal cavity mass with history of epistaxis and which bleeds on probing should be finally assessed under general anaesthesia. It should be excised endoscopically and subjected to histopathological examination<span lang="EN-IN">.</span></p>

scholarly journals Application of microRNA-34a for diagnosis of pleomorphic adenomas of salivary glands

2019 ◽  
Vol 86 (10) ◽  
pp. 67-70
Author(s):  
I. S. Brodetskyi ◽  
V. O. Malanchuk ◽  
V. E. Dosenko
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Quantitative Polymerase Chain Reaction ◽  
Venous Blood ◽  
Benign Tumors ◽  
Intact Tissue ◽  
Salivary Gland Tissue ◽  
Pleomorphic Adenomas ◽  
Gland Tissue

Objective. Determination of expression of microRNA-34a in tissues of pleomorphic adenomas of large salivary glands, adjacent to tumor salivary gland tissue, intact tissue of a salivary gland, which was not connected with the tumor, and in a venous blood as well. Materials and methods. The investigation was conducted in 20 patients, suffering benign tumors of large salivary glands (pleomorphic adenomas). Expression  was estimated, using adverse transcription and quantitative polymerase chain reaction in regime of a real time. Results. Analysis of the expression level for microRNA-34a was conducted in the tumoral tissue, adjacent to the tumor salivary gland tissue, and in intact tissue of salivary gland, which lacked a link with the tumor, the venous blood in patients, suffering pleomorphic adenomas of large salivary glands, and there was revealed, that it have appeared the highest in the salivary gland adjacent to the tumor - (1052.02 ± 367.20, comparing with the same index in the intact gland - 47.72 ± 28.93). Conclusion. Level of expression of microRNA-34a in the tissues of pleomorphic adenomas of salivary glands, which is in 11 times higher, than in norm (in intact tissue of salivary gland), may be applied as a genetic marker for verification of these tumors.

scholarly journals Cicatricial Organizing Pneumonia with Dendriform Pulmonary Ossification: An Unusual Cause for a Recurrent Pneumothorax

2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Mnahi Bin Saeedan ◽  
Carol Farver ◽  
Atul C. Mehta ◽  
Ruchi Yadav
Keyword(s):  
Differential Diagnosis ◽  
Bone Formation ◽  
Ct Scan ◽  
Spontaneous Pneumothorax ◽  
Lower Lobe ◽  
Organizing Pneumonia ◽  
Recurrent Pneumothorax ◽  
History Of ◽  
Thoracoscopic Biopsy ◽  
Metaplastic Bone

Cicatricial organizing pneumonia is an uncommon form of organizing pneumonia, which may manifest as persisting linear opacities on computerized tomography (CT) scan mimicking a fibrosing interstitial pneumonia. It may also manifest with pulmonary ossification, which is a metaplastic bone formation within the lung tissue. The latter presentation could be either nodular or dendriform, both secondary to underlying lung disease and rarely idiopathic. Dendriform pulmonary ossification (DPO) has rarely been described as a cause of spontaneous pneumothorax. We present a case of a 55-year-old male with history of recurrent pneumothoraces and worsening dyspnea on exertion. A CT of the chest revealed progressive bilateral sub-pleural and peribronchovascular reticular opacities associated with densely ossified branching and nodular opacities. Video-assisted thoracoscopic biopsy of the lung demonstrated cicatricial organizing pneumonia with areas of marked diffuse DPO. The case highlights that dendriform pulmonary ossification arising from cicatricial organizing pneumonia should be considered in the differential diagnosis of recurrent pneumonias among patients with lower lobe sub-pleural reticular opacities. The case highlights that dendriform pulmonary ossification rarely can cause spontaneous pneumothorax and can be associated with cicatricial organizing pneumonia and reticular opacities on imaging.

scholarly journals Cystic fibrohistiocytic tumor of the lung presenting as a solitary lesion

Rare Tumors ◽  
2010 ◽  
Vol 2 (1) ◽  
pp. 40-42 ◽  
Author(s):  
Massimiliano Paci ◽  
Alberto Cavazza ◽  
Valerio Annessi ◽  
Tommaso Ricchetti ◽  
Cristian Rapicetta ◽  
...  
Keyword(s):  
Lower Lobe ◽  
Pulmonary Nodules ◽  
Endometrial Stromal Sarcoma ◽  
Pleuropulmonary Blastoma ◽  
Low Grade ◽  
Solitary Lesion ◽  
Stromal Sarcoma ◽  
Pulmonary Cysts ◽  
History Of ◽  
Single Lesion

Cystic fibrohistiocytic tumor of the lung is a rare neoplasm. In many cases it represents a metastasis from a benign or low-grade fibrohistiocytic tumor of the skin, but occasionally it may be primary. Radiologically it usually occurs as a cystic change of multiple pulmonary nodules, and pneumothorax is the most frequent presenting symptom. We present here a 16-year-old man with recurrent right pneumothorax. The patient had no history of cutaneous fibrohistiocytic lesions. He underwent videothoracoscopic right apical segmentectomy, right lower lobe nodulectomy, and pleuroabrasion. Microscopy of the apical segmentectomy showed a cystic fibrohistiocytic tumor, whereas the nodule of the lower lobe was an intraparenchymal lymph node. The patient is alive with no tumor recurrence. The differential diagnosis includes Langerhans cell histiocytosis, lymphangioleiomyomatosis, pleuropulmonary blastoma, and metastatic endometrial stromal sarcoma. This disease usually occurs with multiple pulmonary cysts and cavitation. This case is the first reported presenting as a single lesion.

scholarly journals Searching for the Culprit: Metastases from a Cancer of Unknown Primary

2018 ◽  
Vol 11 (2) ◽  
pp. 541-548 ◽  
Author(s):  
Rita Dorantes-Heredia ◽  
Daniel Motola-Kuba ◽  
Jose Manuel Ruiz-Morales ◽  
Wallace Rafael A. Muñoz-Castañeda ◽  
Carolina Vega-Ochoa ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Ct Scan ◽  
Lobular Carcinoma ◽  
Cancer Of Unknown Primary ◽  
Unknown Primary ◽  
Axillary Lymph ◽  
Pet Ct ◽  
Pleomorphic Lobular Carcinoma ◽  
History Of ◽  
Bone Structures

We report a case of metastases from a cancer of unknown primary whose primary site could not be identified during the appropriate pretreatment evaluation. The patient was a 58-year-old woman with a history of passive smoking and with no history of cancer in the family. Her current condition started with asthenia, adynamia, and pallor, followed by palpitations. An abdominopelvic computed tomography (CT) scan was performed, showing multiple osteolytic lesions distributed in all bone structures and axillary adenopathy on the left side. As part of the approach and given the high suspicion of multiple myeloma, tests were performed. The results were negative for multiple myeloma. A PET-CT scan was performed and showed left axillary adenopathy. The breasts and other organs were not affected. Left axillary lymph node resection revealed breast primary metastatic pleomorphic lobular carcinoma. Due to the metastatic disease (caused by the primary breast cancer), it was decided to start chemotherapy.

Sign in / Sign up

Export Citation Format

Share Document