A Diagnosis to Wrestle With: Intraventricular Angiomatoid Fibrous Histiocytoma

2019 ◽  
Vol 152 (Supplement_1) ◽  
pp. S63-S64
Author(s):  
Margaux Canevari ◽  
Bryan Keenan ◽  
Iren Horkayne-Szakaly ◽  
Markku Miettinen
Keyword(s):  
Plasma Cell ◽  
Fibrous Histiocytoma ◽  
S100 Protein ◽  
Cell Component ◽  
Angiomatoid Fibrous Histiocytoma ◽  
Spine Ct ◽  
Visual Problems ◽  
Lymphoplasmacytic Infiltration ◽  
The Right

Abstract We report a case of a 15-year-old boy who presented with an intraventricular angiomatoid fibrous histiocytoma. The patient suffered a concussion during a wrestling match and underwent a head and spine CT, which prompted an MRI. MRI revealed an enhancing 2.3-cm mass in the posterior horn of the right lateral ventricle with no hydrocephalus. The patient subsequently admitted to having had headaches with associated appetite suppression but no visual problems or weakness. The tumor was resected. It was composed of sheets and cords of histiocytoid cells with focal pleomorphism. Interspersed throughout was a robust lymphoplasmacytic infiltration with Russell bodies and lymphoid follicles. The histiocytoid neoplastic cells were desmin, EMA, and sparsely S100 protein positive. They were negative for CD31, CD34, Cam 5.2, CD163, CD1a, HMB45, Melan-A, progesterone, and ERG. The abundant plasma cell population was confirmed by CD138 reactivity and was polyclonal by kappa and lambda immunohistochemistry. Fluorescence in situ hybridization revealed an EWSR gene rearrangement. The patient was radiographically free of disease 3 years after surgery with headaches as residual sequela. The differential diagnosis for this case included a lymphoplasmacyte-rich meningioma or a plasmacytoma. The EWSR rearrangement made both of these unlikely. The polyclonal nature of the plasma cell component and the age of the patient also argued against plasmacytoma. A literature search revealed one other ventricular-based angiomatoid fibrous histiocytoma in a pediatric patient.

scholarly journals Spindle Cell Melanoma Harboring a Nodule of Epitheloid Cell Melanoma Component: A Study of a Diagnostically Challenging Case

2021 ◽  
Vol 21 (1) ◽  
pp. 26-33
Author(s):  
V Bartos ◽  
A. Farkasova
Keyword(s):  
Spindle Cell ◽  
S100 Protein ◽  
Epithelioid Cell ◽  
Skin Tumor ◽  
Cell Component ◽  
Diagnostic Dilemma ◽  
Ki 67 ◽  
Proliferation Indices ◽  
Human Neoplasm ◽  
The Right

Abstract Background: Melanoma is a very heterogeneous human neoplasm. In addition to four major (conventional) histologic subtypes a number of uncommon variants do exist. Objective: An unusual case of a spindle cell melanoma (SCM) containing a demarcated nodule of conventional epitheliod cell melanoma component is described. Material and Methods: A 71-year-old man manifested with a protuberated ulcerated skin tumor arising on the right forearm. The resected biopsy was analyzed immunohistochemically with a variety of anti-human antibodies. Results: The tumor consisted of a highly cellular mass of spindle-shaped cells without any significant intratu-moral fibrosis. In addition, a nodule of epithelioid cell tumor component was present within the lesion. The spindle cell component showed a disperse reactivity for S100 protein and was negative for other melanocytic markers. It exhibited a very high mitotic activity and proliferation Ki-67 index. No melanin pigment was detected. In contrast, the epithelioid cell component was strongly positive for S100 protein, Melan-A/MART-1, HMB-45, and PNL-2. The mitotic and proliferation indices were much less pronounced and melanin deposits were visible. A diagnosis of a non-desmoplastic SCM harboring a nodule of epithelioid cell melanoma component was established. Conclusion: SCM often posses a diagnostic dilemma because its histomorphology is atypical and its immunohistochemical profile may differ from other subtypes of melanomas. The present paper points out this uncommon histopathological entity that may sometimes be encountered in dermatopathological practice and that requires more complex diagnostic approach.

Intracranial Plasma Cell Granuloma

Neurosurgery ◽  
1989 ◽  
Vol 24 (4) ◽  
pp. 587-590 ◽  
Author(s):  
Michelangelo Gangemi ◽  
Francesco Maiuri ◽  
Arcangelo Giamundo ◽  
Pierarturo Donati ◽  
Annarosaria De Chiara
Keyword(s):  
Plasma Cell ◽  
Exceptional Case ◽  
The Body ◽  
Plasma Cell Granuloma ◽  
Cell Component ◽  
Inflammatory Lesions ◽  
Computed Tomographic ◽  
Intracranial Lesions ◽  
The Right ◽  
Surgical Aspects

ABSTRACT An exceptional case of intracranial plasma cell granuloma, located in the right frontoparietal convexity in a 16-year-old boy is reported. Reports of these rare inflammatory lesions locate them primarily in the lungs and in other regions of the body, and only exceptionally in the nervous system; indeed, only three intracranial cases and one other arising from the spinal meninges have been reported. The computed tomographic and surgical aspects suggested a falx meningioma in our case. The pathological diagnosis differentiating these from other intracranial lesions with a plasma cell component, including meningioma with plasma cell infiltration and plasmacytoma, is discussed.

Angiomatoid fibrous histiocytoma including cases with pleomorphic features analysed by fluorescence in situ hybridisation

2010 ◽  
Vol 63 (2) ◽  
pp. 124-128 ◽  
Author(s):  
T. Matsumura ◽  
T. Yamaguchi ◽  
N. Tochigi ◽  
T. Wada ◽  
T. Yamashita ◽  
...  
Keyword(s):  
Fibrous Histiocytoma ◽  
In Situ Hybridisation ◽  
Fluorescence In Situ Hybridisation ◽  
Angiomatoid Fibrous Histiocytoma

scholarly journals Intracranial temporal bone angiomatoid fibrous histiocytoma: illustrative case

2021 ◽  
Vol 1 (3) ◽  
Author(s):  
Shivani Gillon ◽  
Jacqueline C. Junn ◽  
Emily A. Sloan ◽  
Nalin Gupta ◽  
Alyssa Reddy ◽  
...  
Keyword(s):  
Temporal Bone ◽  
Soft Tissues ◽  
Fibrous Histiocytoma ◽  
Tumor Resection ◽  
Illustrative Case ◽  
Imaging Features ◽  
Angiomatoid Fibrous Histiocytoma ◽  
First Case ◽  
Petrous Temporal Bone ◽  
The Right

BACKGROUNDAngiomatoid fibrous histiocytoma (AFH) is a rare, slowly progressive neoplasm that most commonly occurs in soft tissues. AFH rarely occurs in bone such as the calvaria. The authors present a case of AFH in the petrous temporal bone, which, to their knowledge, is the first case of AFH in this location.OBSERVATIONSA 17-year-old girl presented with worsening positional headaches with associated tinnitus and hearing loss. Imaging demonstrated an extraaxial mass extending into the right cerebellopontine angle, with erosion of the petrous temporal bone, with features atypical for a benign process. The patient underwent retrosigmoid craniotomy for tumor resection. Pathology was consistent with a spindle cell tumor, and genetic testing further revealed an EWSR1 gene rearrangement, confirming the diagnosis of AFH. The patient was discharged with no complications. Her symptoms have resolved, and surveillance imaging has shown no evidence of recurrence.LESSONSThe authors report the first case of AFH in the petrous temporal bone and only the second known case in the calvaria. This case illustrates the importance of the resection of masses with clinical and imaging features atypical of more benign entities such as meningiomas. It is important to keep AFH in the differential diagnosis for atypical masses in the calvaria and skull base.

scholarly journals Angiomatoid Fibrous Histiocytoma: Case Presentation with Review of Literature

Osteology ◽  
2021 ◽  
Vol 1 (3) ◽  
pp. 112-117
Author(s):  
Gerardo Cazzato ◽  
Anna Colagrande ◽  
Antonietta Cimmino ◽  
Mariella Silecchia ◽  
Teresa Lettini ◽  
...  
Keyword(s):  
Fibrous Histiocytoma ◽  
Surgical Excision ◽  
Malignant Potential ◽  
Review Of Literature ◽  
Review Of The Literature ◽  
Genetic Characteristics ◽  
Case Presentation ◽  
Angiomatoid Fibrous Histiocytoma ◽  
Spindle Cells ◽  
The Right

Angiomatoid fibrous histiocytoma is a rare neoplasm with an intermediate malignant potential, that mostly occurs in the subcutis and features varying proportions of epithelioid, ovoid and spindle cells in a nodular and syncytial growth pattern, with hemorrhagic pseudovascular spaces. Here, we report the clinical case of a 68-year-old man who presented with AFH on the right arm; the disease relapsed a few years after surgical excision. We also conduct a brief review of the literature, focusing on the biological and genetic characteristics and the differential diagnosis from other more or less similar entities.

Angiomatoid Fibrous Histiocytoma

2016 ◽  
Vol 78 (3) ◽  
pp. 219-220
Author(s):  
Yoshihiko Inoue ◽  
Shiho Terawaki ◽  
Kazuko Imamura ◽  
Yumiko Kubota ◽  
Masazumi Tsuneyoshi ◽  
...  
Keyword(s):  
Fibrous Histiocytoma ◽  
Angiomatoid Fibrous Histiocytoma

scholarly journals Intrascrotal lipoblastoma in adulthood

2019 ◽  
Vol 12 (12) ◽  
pp. e231320
Author(s):  
Mário José Pereira-Lourenço ◽  
Duarte Vieira-Brito ◽  
João Pedro Peralta ◽  
Noémia Castelo-Branco
Keyword(s):  
Case Report ◽  
Magnetic Resonance ◽  
S100 Protein ◽  
Surgical Excision ◽  
Large Mass ◽  
Histological Diagnosis ◽  
Physical Exam ◽  
Nodular Lesion ◽  
Inferior Portion ◽  
The Right

This case report describes the case of a 37-year-old man that noticed an intrascrotal right mass with 1 month of evolution. During physical exam presented with a large mass at the inferior portion of the right testicle, clearly separated from the testicle, with a tender consistency and mobile. An ultrasound was performed that showed a solid and subcutaneous nodular lesion, extra testicular, heterogeneous, measuring 7.2 cm. Pelvic magnetic resonance imageMRI showed a lesion compatible with a lipoma. The patient was subjected to surgical excision of the lesion by scrotal access, having histology revealed a lipoblastoma (LB) of the scrotum. Histological diagnosis was obtained by microscopic characteristics (well-circumscribed fatty neoplasm) and immunohistochemistry (stains for CD34, S100 protein and PLAG1 were positive; stains for MDM2 and CDK4 were negative). LB is extremely rare after adolescence in any location, being this first described case of intrascrotal LB described in adulthood.

scholarly journals EXPRESS: Chronic thromboembolic pulmonary hypertension following pulmonary embolism with a right ventricular thrombus: A report of two cases

2021 ◽  
pp. 204589402110136
Author(s):  
Tailong Zhang ◽  
Weitao Liang ◽  
Longrong Bian ◽  
Zhong Wu
Keyword(s):  
Pulmonary Hypertension ◽  
Right Ventricular ◽  
Chronic Thromboembolic Pulmonary Hypertension ◽  
Imaging Features ◽  
Pulmonary Endarterectomy ◽  
Right Heart ◽  
Thromboembolic Pulmonary Hypertension ◽  
The Right ◽  
Cardiac Masses

Right heart thrombus (RHT) accompanied by chronic thromboembolic pulmonary hypertension (CTEPH) is a rare entity. RHT may develop in the peripheral veins or in situ within the right heart chambers. The diagnosis of RHT is challenging, since its symptoms are typically non-specific and its imaging features resemble those of cardiac masses. Here, we report two cases of RHT with CTEPH that presented as right ventricular masses initially. Both patients underwent simultaneous pulmonary endarterectomy (PEA) and resection of the ventricular thrombi. Thus, when mass-like features are confirmed by imaging, RHT should be suspected in patients with CTEPH, and simultaneous RHT resection is required along with PEA.

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