Diabetes and Obesity-Related Genes and the Risk of Neural Tube Defects in the National Birth Defects Prevention Study

Neural tube defects (NTD) are one of the birth defects or congenital abnormalities that occur in the brain and spine, and commonly find in newborns worldwide. Anencephaly and spina bifida are the two prevalent forms of NTD. The incidence of spina bifida happen on average 1 in 1000 cases of birth worldwide and there are 140,000 cases per year worldwide. Source searches were carried out on the online portal of journal publications as many as 20 sources from MedScape, Google Scholar and the Nation Center for Biotechnology Information / NCBI with the keywords “Neural tube defects (NTD), prevention, and spina bifida”. Spina bifida is a congenital abnormality that occurs in the womb due to a failure of closing process the neural tube during the first few weeks of embryonic development which causes the spine not completely close around the developing spinal cord nerves. NTD can ensue multifactorial conditions such as genetic, environmental, and folate deficiency. The use of folic acid supplementation starting at least 3 months before pregnancy, those are 400 mcg (0.4 mg) per day and 800 mcg per day during pregnancy can reduce the risk of developing neural tube defects such as spina bifida. Generally, spina bifida is undertaking by surgery and the regulation of patients comorbid. Public can find out prevention to avoid or reduce the risk of spina bifida so that the incidence of spina bifida can decrease along with the increasing awareness of the community regarding this disease.

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Visualizing the Research Hotspots and Emerging Trends in Neural Tube Defects: A Review

Iranian Journal of Public Health ◽

10.18502/ijph.v49i3.3122 ◽

2020 ◽

Author(s):

Baohong MAO ◽

Chichen ZHANG ◽

Liping YANG ◽

Yanxia WANG ◽

Chunhui SU ◽

...

Keyword(s):

Birth Defects ◽

Neural Tube ◽

Neural Tube Defects ◽

Visualization Analysis ◽

Emerging Trends ◽

Bibliographic Records ◽

Tremendous Progress ◽

Number Of Publications ◽

Research Domain ◽

Research Hotspots

Background: Neural tube defects (NTDs) are among the second most common serious birth defects and constitute a major cause of infant death. Research about NTDs has achieved tremendous progress over the last 50 years. Methods: Visualization analysis has been used to explore the hot topic and their emerging trends in NTDs research domain. The scientific literature of research for NTDs has been retrieved from Web of Science™ Core Collection (1966–2014) databases, and final acquire 9125 related bibliographic records, then analyze time trend, distribution of journals, hot keywords, and try to explore the hot topic and their emerging trends in NTDs research domain using Histcite and CiteSpace. Results: The number of publications about NTDs have shown an increased tendency over the last 50 years although there was on a slight decline. Birth Defects Research Part A published the most articles on NTDs research, followed by Lance and Teratology, and the Lancet had the greatest number of total citations. The largest cited frequency keywords was the “Folate”, followed by “Pregnancy”, “Prevention”, and “Spina bifida”. The research hotspots in NTDs research were homocysteine, anencephaly, and screening. Conclusion: With the help of visualization analysis, we explore a quantitative and efficient way of understanding the NTDs knowledge field. Keywords: Visualization analysis; Neural tube defects; Scientometrics; CiteSpace

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Recommendations for accelerating global action to prevent folic acid-preventable birth defects and other folate-deficiency diseases: Meeting of experts on preventing folic acid-preventable neural tube defects

Birth Defects Research Part A Clinical and Molecular Teratology ◽

10.1002/bdra.20058 ◽

2004 ◽

Vol 70 (11) ◽

pp. 835-837 ◽

Cited By ~ 26

Author(s):

Godfrey P. Oakley ◽

Karen N. Bell ◽

Mary Beth Weber

Keyword(s):

Folic Acid ◽

Birth Defects ◽

Neural Tube ◽

Neural Tube Defects ◽

Folate Deficiency ◽

Global Action ◽

Deficiency Diseases

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Assessing bottled water nitrate concentrations to evaluate total drinking water nitrate exposure and risk of birth defects

Journal of Water and Health ◽

10.2166/wh.2014.237 ◽

2014 ◽

Vol 12 (4) ◽

pp. 755-762 ◽

Cited By ~ 11

Author(s):

Peter J. Weyer ◽

Jean D. Brender ◽

Paul A. Romitti ◽

Jiji R. Kantamneni ◽

David Crawford ◽

...

Keyword(s):

Drinking Water ◽

Water Use ◽

Birth Defects ◽

Neural Tube ◽

Neural Tube Defects ◽

Heart Defects ◽

Maternal Exposure ◽

Bottled Water ◽

Nitrate Concentrations ◽

Limb Deficiencies

Previous epidemiologic studies of maternal exposure to drinking water nitrate did not account for bottled water consumption. The objective of this National Birth Defects Prevention Study (NBDPS) (USA) analysis was to assess the impact of bottled water use on the relation between maternal exposure to drinking water nitrate and selected birth defects in infants born during 1997–2005. Prenatal residences of 1,410 mothers reporting exclusive bottled water use were geocoded and mapped; 326 bottled water samples were collected and analyzed using Environmental Protection Agency Method 300.0. Median bottled water nitrate concentrations were assigned by community; mothers' overall intake of nitrate in mg/day from drinking water was calculated. Odds ratios for neural tube defects, limb deficiencies, oral cleft defects, and heart defects were estimated using mixed-effects models for logistic regression. Odds ratios (95% CIs) for the highest exposure group in offspring of mothers reporting exclusive use of bottled water were: neural tube defects [1.42 (0.51, 3.99)], limb deficiencies [1.86 (0.51, 6.80)], oral clefts [1.43 (0.61, 3.31)], and heart defects [2.13, (0.87, 5.17)]. Bottled water nitrate had no appreciable impact on risk for birth defects in the NBDPS.

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