scholarly journals Geographic and urban–rural disparities in the total prevalence of neural tube defects and their subtypes during 2006–2008 in China: a study using the hospital-based birth defects surveillance system

2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Xiaohong Li ◽  
Jun Zhu ◽  
Yanping Wang ◽  
Dezhi Mu ◽  
Li Dai ◽  
...  
Keyword(s):  
Birth Defects ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Surveillance System ◽  
Total Prevalence ◽  
Urban Rural

scholarly journals Mengenal Spina Bifida dan Pencegahannya

2021 ◽  
Vol 1 (12) ◽  
pp. 896-903
Author(s):  
Genta Faesal Atsani ◽  
Zanetha Mauly Ilawanda ◽  
Ilma Fahira Basyir
Keyword(s):  
Spina Bifida ◽  
Birth Defects ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Congenital Abnormality ◽  
Congenital Abnormalities ◽  
Folic Acid Supplementation ◽  
Online Portal ◽  
The Brain ◽  
Developing Spinal Cord

Neural tube defects (NTD) are one of the birth defects or congenital abnormalities that occur in the brain and spine, and commonly find in newborns worldwide. Anencephaly and spina bifida are the two prevalent forms of NTD. The incidence of spina bifida happen on average 1 in 1000 cases of birth worldwide and there are 140,000 cases per year worldwide. Source searches were carried out on the online portal of journal publications as many as 20 sources from MedScape, Google Scholar and the Nation Center for Biotechnology Information / NCBI with the keywords “Neural tube defects (NTD), prevention, and spina bifida”. Spina bifida is a congenital abnormality that occurs in the womb due to a failure of closing process the neural tube during the first few weeks of embryonic development which causes the spine not completely close around the developing spinal cord nerves. NTD can ensue multifactorial conditions such as genetic, environmental, and folate deficiency. The use of folic acid supplementation starting at least 3 months before pregnancy, those are 400 mcg (0.4 mg) per day and 800 mcg per day during pregnancy can reduce the risk of developing neural tube defects such as spina bifida. Generally, spina bifida is undertaking by surgery and the regulation of patients comorbid. Public can find out prevention to avoid or reduce the risk of spina bifida so that the incidence of spina bifida can decrease along with the increasing awareness of the community regarding this disease.

Visualizing the Research Hotspots and Emerging Trends in Neural Tube Defects: A Review

2020 ◽  
Author(s):  
Baohong MAO ◽  
Chichen ZHANG ◽  
Liping YANG ◽  
Yanxia WANG ◽  
Chunhui SU ◽  
...  
Keyword(s):  
Birth Defects ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Visualization Analysis ◽  
Emerging Trends ◽  
Bibliographic Records ◽  
Tremendous Progress ◽  
Number Of Publications ◽  
Research Domain ◽  
Research Hotspots

Background: Neural tube defects (NTDs) are among the second most common serious birth defects and constitute a major cause of infant death. Research about NTDs has achieved tremendous progress over the last 50 years. Methods: Visualization analysis has been used to explore the hot topic and their emerging trends in NTDs research domain. The scientific literature of research for NTDs has been retrieved from Web of Science™ Core Collection (1966–2014) databases, and final acquire 9125 related bibliographic records, then analyze time trend, distribution of journals, hot keywords, and try to explore the hot topic and their emerging trends in NTDs research domain using Histcite and CiteSpace. Results: The number of publications about NTDs have shown an increased tendency over the last 50 years although there was on a slight decline. Birth Defects Research Part A published the most articles on NTDs research, followed by Lance and Teratology, and the Lancet had the greatest number of total citations. The largest cited frequency keywords was the “Folate”, followed by “Pregnancy”, “Prevention”, and “Spina bifida”. The research hotspots in NTDs research were homocysteine, anencephaly, and screening. Conclusion: With the help of visualization analysis, we explore a quantitative and efficient way of understanding the NTDs knowledge field.   Keywords: Visualization analysis; Neural tube defects; Scientometrics; CiteSpace

scholarly journals Diabetes and Obesity-Related Genes and the Risk of Neural Tube Defects in the National Birth Defects Prevention Study

2012 ◽  
Vol 176 (12) ◽  
pp. 1101-1109 ◽  
Author(s):  
P. J. Lupo ◽  
M. A. Canfield ◽  
C. Chapa ◽  
W. Lu ◽  
A. J. Agopian ◽  
...  
Keyword(s):  
Birth Defects ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Prevention Study ◽  
Diabetes And Obesity

scholarly journals Assessing bottled water nitrate concentrations to evaluate total drinking water nitrate exposure and risk of birth defects

2014 ◽  
Vol 12 (4) ◽  
pp. 755-762 ◽  
Author(s):  
Peter J. Weyer ◽  
Jean D. Brender ◽  
Paul A. Romitti ◽  
Jiji R. Kantamneni ◽  
David Crawford ◽  
...  
Keyword(s):  
Drinking Water ◽  
Water Use ◽  
Birth Defects ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Heart Defects ◽  
Maternal Exposure ◽  
Bottled Water ◽  
Nitrate Concentrations ◽  
Limb Deficiencies

Previous epidemiologic studies of maternal exposure to drinking water nitrate did not account for bottled water consumption. The objective of this National Birth Defects Prevention Study (NBDPS) (USA) analysis was to assess the impact of bottled water use on the relation between maternal exposure to drinking water nitrate and selected birth defects in infants born during 1997–2005. Prenatal residences of 1,410 mothers reporting exclusive bottled water use were geocoded and mapped; 326 bottled water samples were collected and analyzed using Environmental Protection Agency Method 300.0. Median bottled water nitrate concentrations were assigned by community; mothers' overall intake of nitrate in mg/day from drinking water was calculated. Odds ratios for neural tube defects, limb deficiencies, oral cleft defects, and heart defects were estimated using mixed-effects models for logistic regression. Odds ratios (95% CIs) for the highest exposure group in offspring of mothers reporting exclusive use of bottled water were: neural tube defects [1.42 (0.51, 3.99)], limb deficiencies [1.86 (0.51, 6.80)], oral clefts [1.43 (0.61, 3.31)], and heart defects [2.13, (0.87, 5.17)]. Bottled water nitrate had no appreciable impact on risk for birth defects in the NBDPS.

scholarly journals Magnitude of Neural Tube Defects and Associated Risk Factors at Three Teaching Hospitals in Addis Ababa, Ethiopia

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Abel Gedefaw ◽  
Sisay Teklu ◽  
Birkneh Tilahun Tadesse
Keyword(s):  
Risk Factors ◽  
Folic Acid ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Family Income ◽  
Addis Ababa ◽  
Teaching Hospitals ◽  
Local Data ◽  
Cross Sectional ◽  
Total Prevalence

There is scarcity of data on prevalence of neural tube defects (NTDs) in lower-income countries. Local data are important to understand the real burden of the problem and explore risk factors to design and implement preventive approaches. This study aimed to determine prevalence and risk factors of NTDs. A hospital-based cross-sectional and unmatched case-control study was conducted at three teaching hospitals of Addis Ababa University. NTDs were defined as cases of anencephaly, spina bifida, and encephalocele based on ICD-10 criteria. The prevalence of NTDs was calculated per 10,000 births for both birth and total prevalence. During seven months, we observed 55 cases of NTDs out of 8677 births after 28 weeks of gestation—birth prevalence of 63.4 per 10,000 births (95% confidence interval (CI), 51–77). A total of 115 cases were medically terminated after 12 weeks of gestation. Fifty-six of these terminations (48.7%) were due to NTDs. Thus, total prevalence of NTDs after 12 weeks’ gestation is 126 per 10,000 births (95% CI, 100–150). Planned pregnancy (adjusted odds ratio (aOR), 0.47; 95% CI, 0.24–0.92), male sex (aOR, 0.56; 95% CI, 0.33–0.94), normal or underweight body mass index (aOR, 0.49; 95%, 0.29–0.95), and taking folic acid or multivitamins during first trimester (aOR, 0.47; 95%, 0.23–0.95) were protective of NTDs. However, annual cash family income less than $1,300 USD (aOR, 2.5; 95%, 1.2–5.5), $1,300–1,800 USD (aOR, 2.8; 95%, 1.3–5.8), and $1,801–2,700 USD (aOR, 2.6; 95%, 1.2–5.8) was found to be risk factors compared to income greater than $2,700 USD. The prevalence of NTDs was found to be high in this setting. Comprehensive preventive strategies focused on identified risk factors should be urgently established. More studies on prevention strategies, including folic acid supplementations, should be conducted in the setting.

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