Ambient Fine Particulate Matter and Preterm Birth in California: Identification of Critical Exposure Windows

2019 ◽  
Vol 188 (9) ◽  
pp. 1608-1615 ◽  
Author(s):  
Paige Sheridan ◽  
Sindana Ilango ◽  
Tim A Bruckner ◽  
Qiong Wang ◽  
Rupa Basu ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Preterm Birth ◽  
Proportional Hazards ◽  
Fine Particulate Matter ◽  
Cox Proportional Hazards ◽  
Distributed Lag ◽  
Fine Particulate ◽  
Cox Proportional Hazards Models ◽  
Pm2.5 Exposure ◽  
Exposure Windows

Abstract Exposure to ambient fine particulate matter (particulate matter ≤2.5 μm in aerodynamic diameter (PM2.5)) during pregnancy is associated with preterm birth (PTB), a leading cause of infant morbidity and mortality. Results from studies attempting to identify etiologically relevant exposure periods of vulnerability have been inconsistent, possibly because of failure to consider the time-to-event nature of the outcome and lagged exposure effects of PM2.5. In this study, we aimed to identify critical exposure windows for weekly PM2.5 exposure and PTB in California using California birth cohort data from 2005–2010. Associations were assessed using distributed-lag Cox proportional hazards models. We assessed effect-measure modification by race/ethnicity by calculating the weekly relative excess risk due to interaction. For a 10-μg/m3 increase in PM2.5 exposure over the entire period of gestation, PTB risk increased by 11% (hazard ratio = 1.11, 95% confidence interval: 1.09, 1.14). Gestational weeks 17–24 and 36 were associated with increased vulnerability to PM2.5 exposure. We find that non-Hispanic black mothers may be more susceptible to effects of PM2.5 exposure than non-Hispanic white mothers, particularly at the end of pregnancy. These findings extend our knowledge about the existence of specific exposure periods during pregnancy that have the greatest impact on preterm birth.

scholarly journals The Combined Effects of Fine Particulate Matter and Temperature on Preterm Birth in Seoul, 2010–2016

2021 ◽  
Vol 18 (4) ◽  
pp. 1463
Author(s):  
Youngrin Kwag ◽  
Min-ho Kim ◽  
Shinhee Ye ◽  
Jongmin Oh ◽  
Gyeyoon Yim ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Preterm Birth ◽  
Pregnant Women ◽  
Low Temperatures ◽  
Fine Particulate Matter ◽  
Temperature Data ◽  
Fine Particulate ◽  
The Mean ◽  
Pm2.5 Exposure ◽  
Pm2.5 Concentration

Background: Preterm birth contributes to the morbidity and mortality of newborns and infants. Recent studies have shown that maternal exposure to particulate matter and extreme temperatures results in immune dysfunction, which can induce preterm birth. This study aimed to evaluate the association between fine particulate matter (PM2.5) exposure, temperature, and preterm birth in Seoul, Republic of Korea. Methods: We used 2010–2016 birth data from Seoul, obtained from the Korea National Statistical Office Microdata. PM2.5 concentration data from Seoul were generated through the Community Multiscale Air Quality (CMAQ) model. Seoul temperature data were collected from the Korea Meteorological Administration (KMA). The exposure period of PM2.5 and temperature were divided into the first (TR1), second (TR2), and third (TR3) trimesters of pregnancy. The mean PM2.5 concentration was used in units of ×10 µg/m3 and the mean temperature was divided into four categories based on quartiles. Logistic regression analyses were performed to evaluate the association between PM2.5 exposure and preterm birth, as well as the combined effects of PM2.5 exposure and temperature on preterm birth. Result: In a model that includes three trimesters of PM2.5 and temperature data as exposures, which assumes an interaction between PM2.5 and temperature in each trimester, the risk of preterm birth was positively associated with TR1 PM2.5 exposure among pregnant women exposed to relatively low mean temperatures (<3.4 °C) during TR1 (OR 1.134, 95% CI 1.061–1.213, p < 0.001). Conclusions: When we assumed the interaction between PM2.5 exposure and temperature exposure, PM2.5 exposure during TR1 increased the risk of preterm birth among pregnant women exposed to low temperatures during TR1. Pregnant women should be aware of the risk associated with combined exposure to particulate matter and low temperatures during TR1 to prevent preterm birth.

scholarly journals Fine particulate matter exposure and incidence of stroke

Neurology ◽  
2017 ◽  
Vol 88 (18) ◽  
pp. 1709-1717 ◽  
Author(s):  
Hong Qiu ◽  
Shengzhi Sun ◽  
Hilda Tsang ◽  
Chit-Ming Wong ◽  
Ruby Siu-yin Lee ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Particulate Matter ◽  
Hemorrhagic Stroke ◽  
Proportional Hazards ◽  
Fine Particulate Matter ◽  
Cox Proportional Hazards ◽  
Fine Particulate ◽  
Chinese Cohort ◽  
First Occurrence

Objective:We aimed to assess the association of long-term residential exposure to fine particulate matter (PM) with aerodynamic diameter less than 2.5 μm (PM2.5) with the incidence of stroke and its major subtypes.Methods:We ascertained the first occurrence of emergency hospital admission for stroke in a Hong Kong Chinese cohort of 66,820 older people (65+ years) who enrolled during 1998–2001 (baseline) and were followed up to December 31, 2010. High-resolution (1 × 1 km) yearly mean concentrations of PM2.5 were predicted from local monitoring data and US National Aeronautics and Space Administration satellite data using linear regression. Baseline residential PM2.5 exposure was used as a proxy for long-term exposure. We used Cox proportional hazards to evaluate the risk of incident stroke associated with PM2.5 exposure adjusted for potential confounders, including individual and neighborhood factors.Results:Over a mean follow-up of 9.4 years, we ascertained 6,733 cases of incident stroke, of which 3,526 (52.4%) were ischemic and 1,175 (17.5%) were hemorrhagic. The hazard ratio for every 10 μg/m3 higher PM2.5 concentration was statistically significant at 1.21 (95% confidence interval [CI] 1.04–1.41) for ischemic and non-statistically significant at 0.90 (95% CI 0.70–1.17) for hemorrhagic stroke in fully adjusted model 3. The estimates for ischemic stroke were higher in older participants (>70 years), less educated participants, and in men for current smokers.Conclusion:Long-term PM2.5 exposure was associated with higher risk of incident ischemic stroke, but the association with incident hemorrhagic stroke was less clear.

scholarly journals Ambient Fine Particulate Matter, Nitrogen Dioxide, and Preterm Birth in New York City

2016 ◽  
Vol 124 (8) ◽  
pp. 1283-1290 ◽  
Author(s):  
Sarah Johnson ◽  
Jennifer F. Bobb ◽  
Kazuhiko Ito ◽  
David A. Savitz ◽  
Beth Elston ◽  
...  
Keyword(s):  
New York ◽  
New York City ◽  
Particulate Matter ◽  
Preterm Birth ◽  
Nitrogen Dioxide ◽  
York City ◽  
Fine Particulate Matter ◽  
Fine Particulate

scholarly journals Maternal exposure to fine particulate matter and preterm birth and low birth weight in Africa

2022 ◽  
Vol 160 ◽  
pp. 107053
Author(s):  
Jovine Bachwenkizi ◽  
Cong Liu ◽  
Xia Meng ◽  
Lina Zhang ◽  
Weidong Wang ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Birth Weight ◽  
Preterm Birth ◽  
Low Birth Weight ◽  
Fine Particulate Matter ◽  
Maternal Exposure ◽  
Fine Particulate

Different exposure levels of fine particulate matter and preterm birth: a meta-analysis based on cohort studies

2017 ◽  
Vol 24 (22) ◽  
pp. 17976-17984 ◽  
Author(s):  
Chenchen Liu ◽  
Jiantao Sun ◽  
Yuewei Liu ◽  
Hui Liang ◽  
Minsheng Wang ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Preterm Birth ◽  
Cohort Studies ◽  
Meta Analysis ◽  
Fine Particulate Matter ◽  
Fine Particulate ◽  
Exposure Levels

scholarly journals In Utero Exposure to Fine Particulate Matter Causes Hypertension Due to Impaired Renal Dopamine D1 Receptor in Offspring

2018 ◽  
Vol 46 (1) ◽  
pp. 148-159 ◽  
Author(s):  
Zhengmeng Ye ◽  
Xi Lu ◽  
Yi Deng ◽  
Xinquan Wang ◽  
Shuo Zheng ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Particulate Matter ◽  
Sodium Excretion ◽  
Fine Particulate Matter ◽  
In Utero ◽  
D1 Receptor ◽  
In Utero Exposure ◽  
Fine Particulate ◽  
Pm2.5 Exposure ◽  
Renal Dopamine

Background/Aims: Adverse environment in utero can modulate adult phenotypes including blood pressure. Fine particulate matter (PM2.5) exposure in utero causes hypertension in the offspring, but the exact mechanisms are not clear. Renal dopamine D1 receptor (D1R), regulated by G protein-coupled receptor kinase type 4 (GRK4), plays an important role in the regulation of renal sodium transport and blood pressure. In this present study, we determined if renal D1R dysfunction is involved in PM2.5–induced hypertension in the offspring. Methods: Pregnant Sprague–Dawley rats were given an oropharyngeal drip of PM2.5 (1.0 mg/kg) at gestation day 8, 10, and 12. The blood pressure, 24-hour sodium excretion, and urine volume were measured in the offspring. The expression levels of GRK4 and D1R were determined by immunoblotting. The phosphorylation of D1R was investigated using immunoprecipitation. Plasma malondialdehyde and superoxide dismutase levels were also measured in the offspring. Results: As compared with saline-treated dams, offspring of PM2.5-treated dams had increased blood pressure, impaired sodium excretion, and reduced D1R-mediated natriuresis and diuresis, accompanied by decreased renal D1R expression and GRK4 expression. The impaired renal D1R function and increased GRK4 expression could be caused by increased reactive oxidative stress (ROS) induced by PM2.5 exposure. Administration of tempol, a redox-cycling nitroxide, for 4 weeks in the offspring of PM2.5-treated dam normalized the decreased renal D1R expression and increased renal D1R phosphorylation and GRK4 expression. Furthermore, tempol normalized the increased renal expression of c-Myc, a transcription factor that regulates GRK4 expression. Conclusions: In utero exposure to PM2.5 increases ROS and GRK4 expression, impairs D1R-mediated sodium excretion, and increases blood pressure in the offspring. These studies suggest that normalization of D1R function may be a target for the prevention and treatment of the hypertension in offspring of mothers exposed to PM2.5 during pregnancy.

Effects of the ambient fine particulate matter (PM2.5) exposure on urinary metabolic profiles in rats using UPLC-Q-TOF-MS

2019 ◽  
Vol 30 (1) ◽  
pp. 90-94 ◽  
Author(s):  
Lin Zhang ◽  
Tengfei Xu ◽  
Zifeng Pi ◽  
Meizhu Zheng ◽  
Fengrui Song ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Fine Particulate Matter ◽  
Metabolic Profiles ◽  
Fine Particulate ◽  
Pm2.5 Exposure ◽  
Tof Ms
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