Quantitative Determination of Phenylephrine Hydrochloride, Ascorbic Acid and Methapyrilene Hydrochloride in an Anticold Formula

1973 ◽  
Vol 30 (1) ◽  
pp. 77-79
Author(s):  
Albert E. Allen ◽  
V. Das Gupta
Keyword(s):  
Ascorbic Acid ◽  
Quantitative Determination ◽  
Phenylephrine Hydrochloride

ADENOHYPOPHYSEAL LH CONTENT IN NORMAL, ANDROGEN-STERILIZED AND PROGESTERONE-PRIMED STERILE FEMALE RATS

1962 ◽  
Vol 39 (1) ◽  
pp. 13-21 ◽  
Author(s):  
Roger A. Gorski ◽  
Charles A. Barraclough
Keyword(s):  
Ascorbic Acid ◽  
Electrical Stimulation ◽  
Quantitative Determination ◽  
Median Eminence ◽  
Hypothalamic Stimulation ◽  
Female Rats ◽  
Rat Pituitary ◽  
Gland Content ◽  
Stimulation Of

ABSTRACT We have previously suggested that the failure of the androgen-sterilized, persistent-oestrous rat to ovulate, following electrical stimulation of the median eminence structures of the hypothalamus, is due to an insufficiency in adenohypophyseal LH concentration. Using the ovarian ascorbic acid technique for quantitative determination of pituitary LH content, the present studies have demonstrated that the sterile rat pituitary gland contains one-third the LH content of the normal prooestrous gland. Furthermore, not only does progesterone priming of this persistent-oestrous rat result in a 75 % increase in LH concentration, but on hypothalamic stimulation sufficient LH is released to induce ovulation. The decrease in LH concentration which accompanies ovulation in the progesterone-primed, sterile rat is approximately 45 % of the total gland content as compared with a 51 % decrease in pituitary content in the normal cyclic rat.

Quantitative Determination of Phenylephrine Hydrochloride by Column Acetylation Technique

1965 ◽  
Vol 48 (3) ◽  
pp. 579-582
Author(s):  
William R Clark ◽  
Lynn A Rosenberg
Keyword(s):  
Quantitative Determination ◽  
Sodium Borate ◽  
Mean Deviation ◽  
Phenylephrine Hydrochloride

Abstract determination of phenylephrine hydrochloride in combination with other amine-type drugs. The mixture is placed on a sodium borate-Celite column and the nonphenolic amines are removed with chloroform. The phenylephrine remaining on the column is acetylated and removed with a chloroform wash. The acetylated phenylephrine is then saponified with alcoholic KOH and determined spectrophotometrically against standard phenylephrine at about 290 mμ. Recoveries averaged 98.5% with a range of 93.3–101.7%. Mean deviation from the average was 1.8%. The method was adopted as official, first action.

Rapid Screening Procedure for the Determination of Preservatives in Ground Beef: Sulfites, Benzoates, Sorbates, and Ascorbates

1976 ◽  
Vol 59 (4) ◽  
pp. 766-769
Author(s):  
Albert B Karasz ◽  
John J Maxstadt ◽  
Juergen Reher ◽  
Frank Decocco
Keyword(s):  
Ascorbic Acid ◽  
Quantitative Determination ◽  
Sodium Sulfite ◽  
Limit Of Detection ◽  
Ground Beef ◽  
Rapid Screening ◽  
Sodium Ascorbate ◽  
Potassium Sorbate ◽  
Large Numbers

Abstract A procedure is described for the examination of large numbers of ground beef samples for the 4 most commonly used preservatives. A single sample solution is prepared and aliquots are taken for the various tests. Sulfite is determined colorimetrically with acid-bleached p-rosaniline. Ascorbic acid is titrated with 2,6-dichloroindophenol. Benzoic and sorbic acids are measured by ultraviolet absorption. Negative samples are rapidly sorted out in this procedure and positive samples are completed for quantitative determination of the preservative. Recoveries are 95% for sodium sulfite, 103% for sodium benzoate, 90% for potassium sorbate, and 81 % expected recovery for sodium ascorbate. The limit of detection is 0.005% for potassium sorbate, and 0.01% for the 3 other preservatives.

Extraction and quantitative determination of ascorbic acid during different maturity stages of Rosa canina L. fruit

2008 ◽  
Vol 21 (4) ◽  
pp. 300-305 ◽  
Author(s):  
Saeed Nojavan ◽  
Faezeh Khalilian ◽  
Fatemeh Momen Kiaie ◽  
Atyeh Rahimi ◽  
Armin Arabanian ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Quantitative Determination ◽  
Rosa Canina ◽  
Maturity Stages

scholarly journals A Simple and Cost-Effective TLC-Densitometric Method for the Quantitative Determination of Acetylsalicylic Acid and Ascorbic Acid in Combined Effervescent Tablets

Molecules ◽  
2018 ◽  
Vol 23 (12) ◽  
pp. 3115 ◽  
Author(s):  
Alina Pyka-Pająk ◽  
Małgorzata Dołowy ◽  
Wioletta Parys ◽  
Katarzyna Bober ◽  
Grażyna Janikowska
Keyword(s):  
Ascorbic Acid ◽  
Quantitative Determination ◽  
Acetylsalicylic Acid ◽  
High Performance ◽  
Limit Of Detection ◽  
Volume Ratio ◽  
Cost Effective ◽  
Pharmaceutical Formulations ◽  
Limit Of Quantification

A new, simple, and cost-effective TLC-densitometric method has been established for the simultaneous quantitative determination of acetylsalicylic acid and ascorbic acid in combined effervescent tablets. Separation was performed on aluminum silica gel 60F254 plates using chloroform-ethanol-glacial acid at a volume ratio of 5:4:0.03 as the mobile phase. UV densitometry was performed in absorbance mode at 200 nm and 268 nm for acetylsalicylic acid and ascorbic acid, respectively. The presented method was validated as per ICH guidelines by specificity, linearity, accuracy, precision, limit of detection, limit of quantification, and robustness. Method validations indicate a good sensitivity with a low value of LOD and LOQ of both examined active substances. The linearity range was found to be 1.50–9.00 μg/spot and 1.50–13.50 μg/spot for acetylsalicylic and ascorbic acid, respectively. A coefficient of variation that was less than 3% confirms the satisfactory accuracy and precision of the proposed method. The results of the assay of combined tablet formulation equal 97.1% and 101.6% in relation to the label claim that acetylsalicylic acid and ascorbic acid fulfill pharmacopoeial requirements. The developed TLC-densitometric method can be suitable for the routine simultaneous analysis of acetylsalicylic acid and ascorbic acid in combined pharmaceutical formulations. The proposed TLC-densitometry may be an alternative method to the modern high-performance liquid chromatography in the quality control of above-mentioned substances, and it can be applied when HPLC or GC is not affordable in the laboratory.

Optimization of the spectrophotometric method for quantitative determination of ascorbic acid in medicinal forms

2009 ◽  
Vol 43 (6) ◽  
pp. 357-359 ◽  
Author(s):  
E. V. Zykova ◽  
O. V. Ostrovskii ◽  
V. G. Zaitsev ◽  
G. P. Dudchenko
Keyword(s):  
Ascorbic Acid ◽  
Quantitative Determination ◽  
Spectrophotometric Method
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