Commentary on: Hypochlorous Acid Versus Povidone-Iodine Containing Irrigants: Which Antiseptic is More Effective for Breast Implant Pocket Irrigation?

2018 ◽  
Vol 38 (7) ◽  
pp. 728-730 ◽  
Author(s):  
Roger N Wixtrom
Keyword(s):  
Hypochlorous Acid ◽  
Povidone Iodine ◽  
Breast Implant ◽  
Acid Versus

Implants and Breast Pocket Irrigation: Outcomes of Antibiotic, Antiseptic, and Saline Irrigation

2021 ◽  
Author(s):  
Amanda N Awad ◽  
Adee J Heiman ◽  
Ashit Patel
Keyword(s):  
Systematic Review ◽  
Hypochlorous Acid ◽  
Povidone Iodine ◽  
Breast Implant ◽  
Capsular Contracture ◽  
Saline Irrigation ◽  
Concurrent Use ◽  
Significant Difference ◽  
Poor Outcomes ◽  
Reoperation Rates

Abstract Background Breast implant-associated infection and capsular contracture are challenging complications that can result in poor outcomes following implant-based breast surgery. Antimicrobial irrigation of the breast pocket or implant is a widely accepted strategy to prevent these complications, but the literature lacks an evidence-based consensus on the optimal irrigation solution. Objectives The objective of this systematic review is to compare clinical outcomes, specifically capsular contracture, infection, and reoperation rates, associated with the use of antibiotic, antiseptic, and saline irrigation. Methods A systematic review was performed in March 2020 using the following search terms: “breast implant,” “irrigation,” “antibiotic,” “bacitracin,” “antiseptic,” “povidone iodine,” “betadine,” “low concentration chlorhexidine,” and “hypochlorous acid.” Capsular contracture, infection, and reoperation rates were compared using forest plots. Results Out of the 104 articles were screened, 14 met inclusion criteria. There was no significant difference in capsular contracture rates between antibiotic and povidone iodine irrigation, although the data comparing these two groups was limited and confounded by the concurrent use of steroids. Antibiotic irrigation showed a significantly lower rate of capsular contracture compared to saline irrigation and a lower rate of capsular contracture and reoperation compared to no irrigation at all.. Povidone iodine was associated with lower rates of capsular contracture and reoperation compared to saline irrigation but there was no data on infection rates specific to povidone iodine irrigation. Conclusions Our study supports the use of antibiotic or povidone iodine use for breast implant irrigation. Further research is required to better determine which of these two irrigation types is superior.

Povidone-Iodine versus antibiotic irrigation in breast implant surgery: Revival of the ideal solution

2020 ◽  
Vol 73 (2) ◽  
pp. 391-407
Author(s):  
Tru Dang ◽  
Nicholas Yim ◽  
Sailesh Tummala ◽  
Alan A. Parsa ◽  
Fereydoun Don Parsa
Keyword(s):  
Povidone Iodine ◽  
Breast Implant ◽  
Ideal Solution ◽  
Implant Surgery ◽  
The Ideal

scholarly journals Review of the use of nasal and oral antiseptics during a global pandemic

2021 ◽  
Vol 16 (2) ◽  
pp. 119-130
Author(s):  
Christopher Stathis ◽  
Nikolas Victoria ◽  
Kristin Loomis ◽  
Shaun A Nguyen ◽  
Maren Eggers ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Viral Load ◽  
Viral Replication ◽  
Hypertonic Saline ◽  
Hypochlorous Acid ◽  
Povidone Iodine ◽  
Nasal Sprays ◽  
Early Stages ◽  
Global Pandemic

A review of nasal sprays and gargles with antiviral properties suggests that a number of commonly used antiseptics including povidone-iodine, Listerine®, iota-carrageenan and chlorhexidine should be studied in clinical trials to mitigate both the progression and transmission of SARS-CoV-2. Several of these antiseptics have demonstrated the ability to cut the viral load of SARS-CoV-2 by 3–4 log10 in 15–30 s  in vitro. In addition, hypertonic saline targets viral replication by increasing hypochlorous acid inside the cell. A number of clinical trials are in process to study these interventions both for prevention of transmission, prophylaxis after exposure, and to diminish progression by reduction of viral load in the early stages of infection.

scholarly journals Low Efficacy of Hypochlorous Acid Solution Compared to Povidone-iodine in Cataract Surgery Antisepsis

2019 ◽  
Vol 13 (1) ◽  
pp. 29-33
Author(s):  
Piotr Kanclerz ◽  
Andrzej Grzybowski ◽  
Bogdan Olszewski
Keyword(s):  
Acid Solution ◽  
Cataract Surgery ◽  
Hypochlorous Acid ◽  
Povidone Iodine ◽  
Bacterial Load ◽  
Prospective Trial ◽  
City Hospital ◽  
Ringer’S Lactate ◽  
Group A

Background: Hypochlorous Acid Solution (HAS) is a non-irritating, odorless and transparent, pH-neutral substance having antimicrobial activity. Objective: The study aimed to compare the efficacy of HAS with a 10% povidone-iodine (PVI) solution for antisepsis in Phacoemulsification Cataract Surgery (PCS). Methods: Consecutive patients undergoing PCS in the Elbląg City Hospital, Poland, were enrolled in this prospective trial. In the morning just before surgery a swab was taken from the inferior conjunctival fornix of the eye that was to be operated. Patients were assigned to receive conjunctival irrigation with PVI or HAS in the operating room. Three minutes after lavage with PVI or HAS, conjunctival swabs were taken. During surgery the cornea and conjunctival sac were irrigated with Ringer’s lactate. The last swab was taken before removing the eye speculum. Results: Overall, 110 patients completed the study; there were 59 patients in the PVI group and 51 patients in the HAS group. Conjunctival lavage with 10% PVI resulted in a decrease in bacterial load, while HAS application did not. In the HAS group a reduction in bacterial load was found after surgery. Patients after HAS irrigation reported significantly less discomfort associated with conjunctival lavage than with PVI. None of the patients developed postoperative endophthalmitis or any type of eye inflammation within the follow-up period. Conclusions: This study confirms the excellent antibacterial activity of a 10% povidone-iodine solution used for three minutes before cataract surgery. Conjunctival irrigation with Ringer lactate during PCS decreased the bacterial load of the conjunctival sac.

Hypochlorous Acid 0.01% vs Povidone-Iodine 5% for Ocular Antisepsis

2021 ◽  
pp. 247412642110136
Author(s):  
Thomas W. Hejkal ◽  
Lauren A. Maloley ◽  
Layan Kaddoura
Keyword(s):  
Hypochlorous Acid ◽  
Povidone Iodine ◽  
Bacterial Load ◽  
Antimicrobial Effect ◽  
Lower Eyelid ◽  
Eyelid Margin ◽  
Minute Exposure ◽  
Sterile Saline ◽  
Colony Forming Units ◽  
The Mean

Purpose: An alternative ocular antiseptic is needed for patients who do not tolerate povidone-iodine (PI). The purpose of this study is to compare the antimicrobial effect of hypochlorous acid (HA) 0.01% with PI 5% applied topically to the ocular surface. Methods: Swabs of the inferior conjunctiva and posterior lower eyelid margin of 40 patients were taken from both eyes and plated onto blood agar plates. One eye was treated with HA and the other with PI, and swabs were taken after 1-minute exposure. The eye treated with PI was rinsed with sterile saline and another swab was taken. Colony-forming units (CFUs) were recorded after 2 days. Patients rated the level of irritation after treatment in each eye. Results: HA and PI both gave significant reduction in CFUs from baseline ( P < .001 for HA and P = .002 for PI). The mean reduction in logCFU ± 95% CI was 0.850 ± 0.387 or greater for HA and 0.749 ± 0.385 or greater for PI; this was equivalent to a mean reduction of 7.1-fold or greater or 86% or greater (95% CI, 66%-94%) for HA and 5.6-fold or greater or 82% or greater (95% CI, 57%-93%) for PI. CFUs increased in 17 eyes after saline rinse. PI caused substantial irritation in 31 of the 40 participants, whereas no individuals had any irritation from topical HA. Conclusions: Both HA and PI were effective in reducing ocular bacterial load. Unlike PI, HA was not irritating to the eye. Saline rinse after topical PI may increase bacterial counts in some individuals.

scholarly journals The Antibacterial Comparison of 5% and 2.5% Povidone Iodine to 0.01% Hypochlorous Acid Using Corneoscleral Tissue as a Solid-Phase Medium

2021 ◽  
Vol Volume 15 ◽  
pp. 3697-3704
Author(s):  
Regis Kowalski ◽  
Roheena Kamyar ◽  
Michelle Rhee ◽  
Alex Mammen ◽  
Deepinder Dhaliwal ◽  
...  
Keyword(s):  
Hypochlorous Acid ◽  
Povidone Iodine ◽  
Solid Phase ◽  
Phase Medium

Bilateral, chronic, bacterial conjunctivitis in giant fornix syndrome

2022 ◽  
Vol 15 (1) ◽  
pp. e245460
Author(s):  
Patrick Commiskey ◽  
Eve Bowers ◽  
Aidan Dmitriev ◽  
Alex Mammen
Keyword(s):  
Elderly Patients ◽  
Acid Treatment ◽  
Hypochlorous Acid ◽  
Povidone Iodine ◽  
Autologous Serum ◽  
Eye Drops ◽  
Artificial Tears ◽  
Bacterial Conjunctivitis ◽  
Corneal Epithelial ◽  
Systemic Antibiotics

Giant fornix syndrome (GFS) results in chronic, relapsing conjunctivitis in elderly patients with enophthalmos and enlarged fornices, in which infectious material collects and perpetuates inflammation. A 98-year-old woman presented with persistent, bilateral, purulent conjunctivitis; corneal epithelial defects and progressive blepharospasm that did not respond to artificial tears, topical antibiotics and steroids and amniotic membrane grafts. Additional findings of deep-set orbits with enlarged upper fornices were diagnostic of GFS. Over the next 2 months, she responded to a combination of topical and systemic antibiotics, autologous serum eye drops, povidone-iodine forniceal rinses, and hypochlorous acid treatment of the eyelashes. GFS is an important diagnostic consideration in elderly patients with chronic conjunctivitis and deep-set orbits.

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