scholarly journals Genetic Neural Networks: an artificial neural network architecture for capturing gene expression relationships

2018 ◽  
Vol 35 (13) ◽  
pp. 2226-2234 ◽  
Author(s):  
Ameen Eetemadi ◽  
Ilias Tagkopoulos

Abstract Motivation Gene expression prediction is one of the grand challenges in computational biology. The availability of transcriptomics data combined with recent advances in artificial neural networks provide an unprecedented opportunity to create predictive models of gene expression with far reaching applications. Results We present the Genetic Neural Network (GNN), an artificial neural network for predicting genome-wide gene expression given gene knockouts and master regulator perturbations. In its core, the GNN maps existing gene regulatory information in its architecture and it uses cell nodes that have been specifically designed to capture the dependencies and non-linear dynamics that exist in gene networks. These two key features make the GNN architecture capable to capture complex relationships without the need of large training datasets. As a result, GNNs were 40% more accurate on average than competing architectures (MLP, RNN, BiRNN) when compared on hundreds of curated and inferred transcription modules. Our results argue that GNNs can become the architecture of choice when building predictors of gene expression from exponentially growing corpus of genome-wide transcriptomics data. Availability and implementation https://github.com/IBPA/GNN Supplementary information Supplementary data are available at Bioinformatics online.

Author(s):  
Vicky Adriani ◽  
Irfan Sudahri Damanik ◽  
Jaya Tata Hardinata

The author has conducted research at the Simalungun District Prosecutor's Office and found the problem of prison rooms that did not match the number of prisoners which caused a lack of security and a lack of detention facilities and risked inmates to flee. Artificial Neural Network which is one of the artificial representations of the human brain that always tries to simulate the learning process of the human brain. The application uses the Backpropagation algorithm where the data entered is the number of prisoners. Then Artificial Neural Networks are formed by determining the number of units per layer. Once formed, training is carried out from the data that has been grouped. Experiments are carried out with a network architecture consisting of input units, hidden units, and output units. Testing using Matlab software. For now, the number of prisoners continues to increase. Predictions with the best accuracy use the 12-3-1 architecture with an accuracy rate of 75% and the lowest level of accuracy using 12-4-1 architecture with an accuracy rate of 25%.


Author(s):  
Anjar Wanto ◽  
Agus Perdana Windarto ◽  
Dedy Hartama ◽  
Iin Parlina

Artificial Neural Network (ANN) is often used to solve forecasting cases. As in this study. The artificial neural network used is with backpropagation algorithm. The study focused on cases concerning overcrowding forecasting based District in Simalungun in Indonesia in 2010-2015. The data source comes from the Central Bureau of Statistics of Simalungun Regency. The population density forecasting its future will be processed using backpropagation algorithm focused on binary sigmoid function (logsig) and a linear function of identity (purelin) with 5 network architecture model used the 3-5-1, 3-10-1, 3-5 -10-1, 3-5-15-1 and 3-10-15-1. Results from 5 to architectural models using Neural Networks Backpropagation with binary sigmoid function and identity functions vary greatly, but the best is 3-5-1 models with an accuracy of 94%, MSE, and the epoch 0.0025448 6843 iterations. Thus, the use of binary sigmoid activation function (logsig) and the identity function (purelin) on Backpropagation Neural Networks for forecasting the population density is very good, as evidenced by the high accuracy results achieved.


2019 ◽  
Vol 14 (1) ◽  
pp. 58-79 ◽  
Author(s):  
Gaetano Bosurgi ◽  
Orazio Pellegrino ◽  
Giuseppe Sollazzo

Artificial Neural Networks represent useful tools for several engineering issues. Although they were adopted in several pavement-engineering problems for performance evaluation, their application on pavement structural performance evaluation appears to be remarkable. It is conceivable that defining a proper Artificial Neural Network for estimating structural performance in asphalt pavements from measurements performed through quick and economic surveys produces significant savings for road agencies and improves maintenance planning. However, the architecture of such an Artificial Neural Network must be optimised, to improve the final accuracy and provide a reliable technique for enriching decision-making tools. In this paper, the influence on the final quality of different features conditioning the network architecture has been examined, for maximising the resulting quality and, consequently, the final benefits of the methodology. In particular, input factor quality (structural, traffic, climatic), “homogeneity” of training data records and the actual net topology have been investigated. Finally, these results further prove the approach efficiency, for improving Pavement Management Systems and reducing deflection survey frequency, with remarkable savings for road agencies.


2021 ◽  
Vol 3 (1) ◽  
pp. 10-16
Author(s):  
Kris Jayanti ◽  
Katen Lumbanbatu ◽  
Suci Ramadani

Artificial Neural Network (ANN) and time series data can be used for forecasting methods well. Artificial Neural Network is a method whose working principle is adapted from a mathematical model in humans or biological nerves. Neural networks are characterized by; (1) the pattern of connections between neurons (called architecture), (2) determining the weight of the connection (called training or learning), and (3) the activation function. The research objective was to obtain the best artificial neural network architecture, comparing the two methods of Backpropogation Neural Networks with the Radial Base Function Artificial Neural Network (RBF) method. This research is a research using real data (true experimental). This research was conducted at SMK Harapan Bangsa Kuala, which was obtained from 2015 to 2019. The results showed that for one iteration using the backpropagation method the result was 0,378197657 with a squared error 0.143033468, then the results achieved were not in accordance with the target.


Author(s):  
Md. Saqib Hasan ◽  
Rukshar Alam ◽  
Muhammad Abdullah Adnan

Deep learning is a popular topic among machine learning researchers nowadays, with great strides being made in recent years to develop robust artificial neural networks for faster convergence to a reasonable accuracy. Network architecture and hyperparameters of the model are fundamental aspects of model convergence. One such important parameter is the initial values of weights, also known as weight initialization. In this paper, we perform two research tasks concerned with the weights of neural networks. First, we develop three novel weight initialization algorithms inspired by the neuroscientific construction of the mammalian brains and then test them on benchmark datasets against other algorithms to compare and assess their performance. We call these algorithms the lognormal weight initialization, modified lognormal weight initialization, and skewed weight initialization. We observe from our results that these initialization algorithms provide state-of-the-art results on all of the benchmark datasets. Second, we analyze the influence of training an artificial neural network on its weight distribution by measuring the correlation between the quantitative metrics of skewness and kurtosis against the model accuracy using linear regression for different weight initializations. Results indicate a positive correlation between network accuracy and skewness of the weight distribution but no affirmative relation between accuracy and kurtosis. This analysis provides further insight into understanding the inner mechanism of neural network training using the shape of weight distribution. Overall, the works in this paper are the first of their kind in incorporating neuroscientific knowledge into the domain of artificial neural network weights.


Author(s):  
Sony Irwanda ◽  
Jaya Tata Hardinata ◽  
Irfan Sudahri Damanik

This study predicts the number of ticketing by applying Artificial Neural Networks. The application uses the Backpropogation algorithm where the data entered is the number of tickets. Then an Artificial Neural Network is formed by determining the number of units per layer. After the network is formed training is carried out from the data that has been grouped. Experiments are carried out with a network architecture consisting of input units, hidden units, output units and network architecture. Testing is done with Matlab software.


Sensors ◽  
2020 ◽  
Vol 21 (1) ◽  
pp. 47
Author(s):  
Vasyl Teslyuk ◽  
Artem Kazarian ◽  
Natalia Kryvinska ◽  
Ivan Tsmots

In the process of the “smart” house systems work, there is a need to process fuzzy input data. The models based on the artificial neural networks are used to process fuzzy input data from the sensors. However, each artificial neural network has a certain advantage and, with a different accuracy, allows one to process different types of data and generate control signals. To solve this problem, a method of choosing the optimal type of artificial neural network has been proposed. It is based on solving an optimization problem, where the optimization criterion is an error of a certain type of artificial neural network determined to control the corresponding subsystem of a “smart” house. In the process of learning different types of artificial neural networks, the same historical input data are used. The research presents the dependencies between the types of neural networks, the number of inner layers of the artificial neural network, the number of neurons on each inner layer, the error of the settings parameters calculation of the relative expected results.


2016 ◽  
Vol 38 (2) ◽  
pp. 37-46 ◽  
Author(s):  
Mateusz Kaczmarek ◽  
Agnieszka Szymańska

Abstract Nonlinear structural mechanics should be taken into account in the practical design of reinforced concrete structures. Cracking is one of the major sources of nonlinearity. Description of deflection of reinforced concrete elements is a computational problem, mainly because of the difficulties in modelling the nonlinear stress-strain relationship of concrete and steel. In design practise, in accordance with technical rules (e.g., Eurocode 2), a simplified approach for reinforced concrete is used, but the results of simplified calculations differ from the results of experimental studies. Artificial neural network is a versatile modelling tool capable of making predictions of values that are difficult to obtain in numerical analysis. This paper describes the creation and operation of a neural network for making predictions of deflections of reinforced concrete beams at different load levels. In order to obtain a database of results, that is necessary for training and testing the neural network, a research on measurement of deflections in reinforced concrete beams was conducted by the authors in the Certified Research Laboratory of the Building Engineering Institute at Wrocław University of Science and Technology. The use of artificial neural networks is an innovation and an alternative to traditional methods of solving the problem of calculating the deflections of reinforced concrete elements. The results show the effectiveness of using artificial neural network for predicting the deflection of reinforced concrete beams, compared with the results of calculations conducted in accordance with Eurocode 2. The neural network model presented in this paper can acquire new data and be used for further analysis, with availability of more research results.


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