scholarly journals TP7.2.11 Hypochromia is an early marker of iron deficiency anaemia

2021 ◽  
Vol 108 (Supplement_7) ◽  
Author(s):  
Inae Hwang ◽  
Jeremy Cheong ◽  
Sriram Subramonia
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Blood Count ◽  
Full Blood Count ◽  
Gastrointestinal Cancers ◽  
Deficiency Anaemia ◽  
Referral Criteria ◽  
Laboratory Test Results ◽  
Red Cell Indices ◽  
Mean Corpuscular Haemoglobin

Abstract Aim Microcytosis in iron deficiency anaemia triggers an urgent referral for investigation of suspected gastrointestinal cancers. This study evaluated whether the inclusion of hypochromia as a marker for iron deficiency would lead to earlier referrals. Method Consecutive patients referred from primary care under the 2-week wait suspected gastrointestinal cancer pathway with unexplained iron deficiency anaemia between October 2019 and October 2020 were included. Results of red cell indices were obtained from an electronic platform for accessing laboratory test results(Sunquest ICE™, Version 5.4, Sunquest Information Systems). Mean corpuscular haemoglobin (MCH) of 27-32pg and mean corpuscular volume (MCV) of 80-102fL were considered normal. Results Seventy nine patients (32 men, 47 women) were included. Median (IQR) age was 73 (62-80) years. 67% (53/79) had a low MCH and 43% (34/79) had a low MCV at the time of referral. In the preceding months of referral (median [IQR] 4.3 [1.8-7.9] months) 64 patients had a full blood count performed of which 55% (35/64) had a low MCH and 20% (13/64) had a low MCV. The earliest available full blood count prior to referral (43 patients, median (IQR) of 16.5 (12-37) months) showed that 86% (37/43) had a low MCH compared to 33% (14/43) with a low MCV. A fall in MCH always preceded a fall in MCV at all the three time points analysed. Conclusion The inclusion of hypochromia as a marker of iron deficiency in the referral criteria for suspected gastrointestinal cancers would trigger significantly earlier referrals.

scholarly journals The Diagnostic Patterns of Iron Deficiency and Iron Deficiency Anaemia in Children of 6 to 59 Months in Cameroon

2020 ◽  
Vol 2 (4) ◽  
Author(s):  
S. D. Agokeng ◽  
A. L. Njunda ◽  
C. T. Tayou ◽  
C. N. J. Assob
Keyword(s):  
Iron Deficiency ◽  
Mean Corpuscular Volume ◽  
Iron Deficiency Anaemia ◽  
Blood Count ◽  
Ferritin Level ◽  
Full Blood Count ◽  
Corpuscular Volume ◽  
Deficiency Anaemia ◽  
Corpuscular Haemoglobin ◽  
Mean Corpuscular Haemoglobin

A Cross sectional multicentre study was carried out to determine the prevalence of Iron deficiency (ID) and Iron deficiency anaemia (IDA) in children using Ferritin and full blood count. Full blood count was done with Mindray Bc-2800 and Ferritin test with Enzyme Linked Immuno-Sorbent Assay. Authorization was granted by Cameroonian national Ethical Committee. Data were analysed using Statistical Package of Social Sciences 21.0 significant results were considered for P< 0.05. ID varied from 4.2% to 9.6% for cut-offs of 30 and 50μg/L. IDA ranged from 4.2 to 8.5% at these 2 cut-offs. Considering red cells indices, Mean Corpuscular Volume and Mean Corpuscular Haemoglobin blood count currently used should be interpreted cautiously as only Mean Corpuscular Volume and Mean Corpuscular Haemoglobin corroborate with a Ferritin level lower than 30 μg/L.

Haematology and immunology

2020 ◽  
pp. 635-662
Author(s):  
Chantal Simon ◽  
Hazel Everitt ◽  
Françoise van Dorp ◽  
Nazia Hussain ◽  
Emma Nash ◽  
...  
Keyword(s):  
Immune Deficiency ◽  
General Practice ◽  
Iron Deficiency ◽  
Sedimentation Rate ◽  
Iron Deficiency Anaemia ◽  
Blood Count ◽  
Full Blood Count ◽  
Deficiency Anaemia ◽  
Initial Investigation ◽  
Chronic Leukaemia

This chapter in the Oxford Handbook of General Practice explores haematology in general practice. It covers full blood count and erythrocyte sedimentation rate. It explores diagnosis and initial investigation of anaemia, iron deficiency anaemia, haemoglobinopathies, bleeding and clotting disorders, and anticoagulation. It examines haematological malignancy, acute leukaemia, chronic leukaemia and myeloproliferation, lymphoma, immune deficiency, and allergy.

Haematology and immunology

2014 ◽  
pp. 659-686
Author(s):  
Chantal Simon ◽  
Hazel Everitt ◽  
Françoise van Dorp ◽  
Matt Burkes
Keyword(s):  
Immune Deficiency ◽  
Iron Deficiency ◽  
Acute Leukaemia ◽  
Blood Test ◽  
Iron Deficiency Anaemia ◽  
Blood Count ◽  
Full Blood Count ◽  
Deficiency Anaemia ◽  
Initial Investigation ◽  
Chronic Leukaemia

Full blood count and ESR Anaemia: diagnosis and initial investigation Iron deficiency anaemia Other anaemias Haemoglobinopathy Bleeding and clotting disorders Anticoagulation Haematological malignancy Acute leukaemia Chronic leukaemia and myeloproliferation Lymphoma Immune deficiency syndromes Allergies The most commonly requested blood test is the full blood count (FBC). It gives information on:...

scholarly journals Prevalence of Iron Deficiency, Iron Deficiency Anaemia and General Anaemia in Male Gambian Blood Donors Residing in Greater Banjul Region

2021 ◽  
Author(s):  
Mustapha Dibbasey ◽  
Bolarinde Lawal ◽  
Solomon Umukoro ◽  
Peter Mitchel
Keyword(s):  
Iron Deficiency ◽  
Blood Donor ◽  
Iron Deficiency Anaemia ◽  
Blood Count ◽  
Blood Donors ◽  
Blood Donation ◽  
Full Blood Count ◽  
Serum Samples ◽  
Deficiency Anaemia ◽  
Donor Population

AbstractObjectiveThe objective of this study is to determine the prevalence of iron deficiency (ID) and iron deficiency anaemia (IDA) as well as general anaemia in male blood donors and their association with ageing process.Methodology and ResultsA total of two hundred and one (201) serum samples were analysed for ferritin in male Gambian blood donors. The ferritin measurement was achieved with COBAS® INTEGRA 400 plus. At the same time, haemoglobin values were retrospectively obtained from the archived haematological full blood count result in the GARIS database. IDA was defined as (Haemoglobin <13.0g/dL+ Ferritin<15ng/ml) whilst ID was defined as (Haemoglobin ≥13.0g/dL+ Ferritin<15ng/ml) and general anaemia was defined as haemoglobin <13.0g/dL in males. The prevalence of anaemia (20%, n=41), ID (22%, n=44) and IDA (10%, n=21), were recorded in male donors. The results show no relationship between ferritin and haemoglobin among the blood donors (collection coefficient (r) = 0.04). Besides, no linear association of having anaemia and ID with ageing was reported among the blood donor population.Conclusion and potential application of findingsID and IDA as well as general anaemia are highly prevalent among blood donors in the Gambia. Besides, no predisposition to ID and anaemia was observed in term of age, thus all blood donors from 18-60 should be considered for blood donation without any age preference.

scholarly journals Intravenous versus oral iron therapy in treatment of postpartum anaemia

2017 ◽  
Vol 6 (8) ◽  
pp. 3454
Author(s):  
Neelima Agarwal ◽  
Preeti Sharma
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Ferrous Sulphate ◽  
Intravenous Iron ◽  
Hemoglobin Level ◽  
Oral Iron ◽  
Chi Square ◽  
Deficiency Anaemia ◽  
Significant Difference ◽  
Red Cell Indices

Background: Postpartum iron deficiency anaemia (IDA) is common in women. Most women are treated with either oral iron supplementation or blood transfusion. Hence, the aim of our study was to compare the effect of treatment with either oral ferrous sulphate or intravenous ferrous sucrose on postpartum IDA.Methods: 100 postpartum women with proven iron deficiency anaemia with hemoglobin <9gm/dl and serum ferritin <15 µgm/l were included in the study. They were randomized to receive either oral ferrous sulphate 200 mg twice daily for 6 weeks (group 1) or intravenous ferrous sucrose 200 mg, two to three doses given on alternate days (group 2). Total iron deficit was calculated using a standard formula. Target hemoglobin was 11 gm/dl. Results were analysed by the students t-test and chi-square test. Hemoglobin, hematocrit, red cell indices and ferritin were measured on day 2-3, 1-2 weeks and 6 weeks postpartumResults: By 1-2 weeks, hemoglobin level in women treated with intravenous iron had risen from 7.81±0.849 to 9.88±0.760 gm/dl which was more than those treated with oral iron (p<0.01); although by 6 weeks, there was no significant difference between the two groups. Ferritin levels rose rapidly in those treated with intravenous iron and remained significantly higher than in those treated with oral iron (p<0.01).Conclusions: Intravenous iron sucrose increases the hemoglobin level more rapidly than oral ferrous sulphate in women with postpartum IDA. It also replenishes iron stores more rapidly. 

scholarly journals Correlation of iron deficiency anaemia with glycosylated haemoglobin (HbA1c) levels in non-diabetics: an observational study

2021 ◽  
Vol 8 (7) ◽  
pp. 969
Author(s):  
Ajay V. Dhapale ◽  
Omkar Kamble
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Binding Capacity ◽  
Haemoglobin Concentration ◽  
Glycosylated Haemoglobin ◽  
Diabetic Patients ◽  
Deficiency Anaemia ◽  
Corpuscular Haemoglobin ◽  
Mean Corpuscular Haemoglobin ◽  
Iron Binding Capacity

Background: Alteration of HbA1c in other conditions such as haemolytic anaemia, pregnancy and haemoglobinopathy has raised questions about its correlation with iron stores. The aim of the study was to correlate iron deficiency anaemia with glycosylated haemoglobin levels among non-diabetics.Methods: The present study was an observational study among non-diabetic patients of iron deficiency anaemia attending our outpatient department. The study was conducted in the department of medicine of a tertiary care hospital in Maharashtra. All the non-diabetic patients more than 18 years with iron deficiency anaemia were included in the present study. Patients with acute coronary syndromes, chronic liver, chronic kidney diseases, malignancies, haemolytic anaemia, pregnancy, HIV positive with known end stage cardiopulmonary disease were excluded from the study.Results: About 86.33% of the patients had mild to moderate anaemia and 10.7% had severe anaemia in the present study. The average values of haemoglobin, serum ferritin, total iron binding capacity, mean corpuscular volume, mean corpuscular haemoglobin, and mean corpuscular haemoglobin concentration and hematocrit significantly improved after the treatment. With treatment of anaemia, glycosylated haemoglobin, fasting blood sugars and post prandial blood sugars also improved significantly when compared to baseline (p<0.001).Conclusions: The average values of haemoglobin, serum ferritin, total iron binding capacity, mean corpuscular volume, mean corpuscular haemoglobin, and mean corpuscular haemoglobin concentration and hematocrit significantly improved after the treatment. With treatment of anaemia, glycosylated haemoglobin, fasting blood sugars and post prandial blood sugars also improved significantly when compared to baseline.

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