Effect of Blueberry Consumption on Cardiometabolic Health Parameters in Men with Type 2 Diabetes: An 8-Week, Double-Blind, Randomized, Placebo-Controlled Trial

ABSTRACT Background Blueberries are dietary sources of polyphenols, specifically anthocyanins. Anthocyanins have been identified as having a strong association with type 2 diabetes risk reduction; however, to date few human clinical trials have evaluated the potential beneficial health effects of blueberries in populations with type 2 diabetes. Objectives We investigated the effects of blueberry consumption for 8 wk on cardiometabolic parameters in men with type 2 diabetes. Methods In a double-blind, parallel-arm, randomized controlled trial, 52 men who are US veterans [mean baseline characteristics: age, 67 y (range: 51–75 y); weight, 102 kg (range: 80–130 kg); BMI (in kg/m2), 34 (range: 26–45)] were randomly assigned to 1 of 2 intervention groups. The interventions were either 22 g freeze-dried blueberries or 22 g placebo. The study participants were asked to consume 11 g freeze-dried blueberries or placebo with each of their morning and evening meals along with their typical diet. Results Mean ± SE hemoglobin A1c (7.1% ± 0.1% compared with 7.5% ± 0.2%; P = 0.03), fructosamine (275.5 ± 4.1 compared with 292.4 ± 7.9 µmol/L; P = 0.04), triglycerides (179.6 ± 10.1 compared with 199.6 ± 19.9 mg/dL; P = 0.03), aspartate transaminase (23.2 ± 1.4 compared with 30.5 ± 2.7 units/L; P = 0.02), and alanine transaminase (35.6 ± 1.5 compared with 48.3 ± 2.9 units/L; P = 0.0003) were significantly lower for those consuming blueberries for 8 wk than for those consuming the placebo. Fasting plasma glucose concentrations; serum insulin, total cholesterol, LDL-cholesterol, HDL-cholesterol, and C-reactive protein concentrations; blood pressure; and body weight were not significantly different after 8 wk consumption of blueberries compared with the placebo. Conclusions Consumption of 22 g freeze-dried blueberries for 8 wk may beneficially affect cardiometabolic health parameters in men with type 2 diabetes. This trial was registered at clinicaltrials.gov as NCT02972996.

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Effects of Freeze-Dried Strawberry Supplementation on Metabolic Biomarkers of Atherosclerosis in Subjects with Type 2 Diabetes: A Randomized Double-Blind Controlled Trial

Annals of Nutrition and Metabolism ◽

10.1159/000356053 ◽

2013 ◽

Vol 63 (3) ◽

pp. 256-264 ◽

Cited By ~ 44

Author(s):

Sara Moazen ◽

Reza Amani ◽

Aziz Homayouni Rad ◽

Hajieh Shahbazian ◽

Kambiz Ahmadi ◽

...

Keyword(s):

Type 2 Diabetes ◽

Controlled Trial ◽

Double Blind ◽

Freeze Dried ◽

Metabolic Biomarkers

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The effects of combined magnesium and zinc supplementation on metabolic status in patients with type 2 diabetes mellitus and coronary heart disease

10.21203/rs.2.21470/v1 ◽

2020 ◽

Author(s):

Zahra Hamedifard ◽

Alireza Farrokhian ◽

Željko Reiner ◽

Fereshteh Bahmani ◽

Mohsen Taghizadeh ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Coronary Heart Disease ◽

Type 2 Diabetes Mellitus ◽

Heart Disease ◽

Controlled Trial ◽

Hdl Cholesterol ◽

Double Blind ◽

Zinc Supplement

Abstract Background: The present research aimed to analyze the impacts of magnesium and zinc supplement on the metabolic level in the patients suffering from CHD (coronary heart disease) and T2DM (type 2 diabetes mellitus). Methods: According to the research design, a randomized, double-blind, placebo-controlled trial has been implemented on 55 women suffering from CHD and T2DM. Therefore, the participants have been randomly divided into 2 groups for taking placebo (n = 28) or 250 mg magnesium oxide plus 220 mg zinc sulfate (n =27) or for 12 weeks. Results: Magnesium and zinc considerably declined the levels of fasting plasma glucose (FPG) (β -9.44 mg/dL, 95% CI, -18.30, -0.57; P = 0.03) and levels of insulin (β -1.37 µIU/mL, 95% CI, -2.57, -0.18; P = 0.02). Moreover, levels of HDL-cholesterol have been remarkably enhanced (β 2.09 mg/dL, 95% CI, 0.05, 4.13; P = 0.04) in comparison to the placebo. There have been an association between magnesium and zinc intake and a considerable decrease of C-reactive protein (CRP) (β -0.85 mg/L, 95% CI, -1.26, -0.45; P < 0.001), a considerable enhancement in the total nitrite (β 5.13 µmol/L, 95% CI, 1.85, 8.41; P = 0.003), and total anti-oxidant capacities (TAC) (β 43.44 mmol/L, 95% CI, 3.39, 83.50; P=0.03) in comparison to the placebo. Furthermore, magnesium and zinc remarkably reduced the Beck Depression Inventory index (BDI) (β -1.66; 95% CI, -3.32, -0.009; P = 0.04) and Beck Anxiety Inventory (BAI) (β -1.30; 95% CI, -2.43, -0.16; P=0.02) in comparison to the placebo. Conclusions: In patients with T2DM and CVD the 12-week intake of magnesium and zinc affected FPG, HDL-cholesterol, CRP, insulin, NO, TAC levels, and BDI and BAI score usefully. Trial registration: Current Controlled Trials http://www.irct.ir: IRCT20130211012438N31 at 11 May 2019 of registration. This study retrospectively registered.

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Effect of Blueberry Consumption on Mood States in Men With Type 2 Diabetes

Current Developments in Nutrition ◽

10.1093/cdn/nzab037_081 ◽

2021 ◽

Vol 5 (Supplement_2) ◽

pp. 371-371

Author(s):

Kim Stote ◽

Margaret Wilson ◽

Krista Thomas ◽

Joanne Rourke ◽

Aidar Gosmanov

Keyword(s):

Type 2 Diabetes ◽

Mood State ◽

Medical Center ◽

Controlled Trial ◽

Mood States ◽

Mood Disturbance ◽

Double Blind ◽

Total Mood Disturbance ◽

Freeze Dried

Abstract Objectives The study investigated the effects of blueberry consumption for 8 weeks on subjective mood states in men with type 2 diabetes. Methods In a double-blind, parallel randomized controlled trial, 37 men who are U.S. veterans (mean baseline characteristics: 67 years, range: 51–74 years; body mass index (BMI), 34 kg/m2, range: 26–44 kg/m2) were randomly assigned to 1 of 2 intervention groups. The interventions were either 22 g of freeze-dried blueberries (equivalent to 1 cup fresh blueberries) or 22 g of a placebo (matched in energy and carbohydrate content to the blueberries). The Profile of Mood States (POMS) was assessed twice using POMS 2 65-item questionnaire at the beginning (week 0) and at the end of the study (week 8). Increases in Vigor-Activity and Friendliness scores indicate a positive mood state. Increases in Total Mood Disturbance, Anger-Hostility, Confusion-Bewilderment, Depression-Dejection, Fatigue-Inertia, and Tension-Anxiety scores indicate a negative mood state. Results Vigor-Activity, Friendliness, Total Mood Disturbance, Anger-Hostility, Confusion-Bewilderment, Depression-Dejection, Fatigue-Inertia and Tension-Anxiety scores were not significantly different after 8 weeks of consumption of blueberries compared with the placebo. Total Mood Disturbance (38.7 ± 1.8 vs. 41.1 ± 2.5, respectively; P = 0.034) and Confusion-Bewilderment (37.3 ± 2.1 vs. 41.6 ± 3.0, respectively; P = 0.044) scores were significantly lower for those consuming blueberries for 8 weeks compared with the placebo in subgroup analysis of men with lower baseline Total Mood Disturbance scores (<45). Conclusions Consumption of 22 g freeze-dried blueberries for 8 weeks may beneficially affect some mood states in men with type 2 diabetes. Funding Sources The U.S. Highbush Blueberry Council; the study is the result of work supported with resources and the use of facilities at the Stratton VA Medical Center, Albany, NY, USA.

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A randomized controlled trial of two diets enriched with protein or fat in patients with type 2 diabetes treated with dapagliflozin

Scientific Reports ◽

10.1038/s41598-021-90879-z ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Yasuhiro Watanabe ◽

Daisuke Suzuki ◽

Nobuichi Kuribayashi ◽

Daigaku Uchida ◽

Mitsutoshi Kato ◽

...

Keyword(s):

Type 2 Diabetes ◽

Muscle Mass ◽

Body Fat ◽

Fat Mass ◽

Serum Insulin ◽

Controlled Trial ◽

Hdl Cholesterol ◽

Body Fat Mass ◽

Randomized Controlled

AbstractSodium-glucose cotranspsorter-2 (SGLT2) inhibitors (SGLT2i) involve loss of skeletal muscle mass, potentially leading to inadequate HbA1c reduction in type 2 diabetes (T2DM), since muscle mass is related to insulin sensitivity. The benefit of protein-enriched diet for improving HbA1c in SGLT2i-treated T2DM patients remains unclear. We conducted a multicenter, double-blind, randomized, controlled, investigator-initiated clinical trial. 130 T2DM patients treated with dapagliflozin (5 mg) were randomized to isoenergic protein-rich formula diet (P-FD) or fat-rich FD (F-FD) (1:1 allocation) to replace one of three meals/day for 24 weeks. Primary outcome was change in HbA1c. Secondary outcomes were changes in serum insulin, body composition and other metabolic parameters. Although HbA1c decreased significantly in both groups [mean (95% confidence interval) − 0.7% (− 0.9 to − 0.5) in P-FD, − 0.6% (− 0.8 to − 0.5) in F-FD], change in HbA1c was not significantly different between the two groups (P = 0.4474). Fasting insulin and body fat mass decreased, while HDL-cholesterol increased significantly in P-FD, and these changes were significantly greater compared with F-FD (all, P < 0.05). In T2DM treated with dapagliflozin, protein-enriched diet does not contribute to HbA1c reduction, although it decreases serum insulin and body fat mass, and increases HDL-cholesterol compared with fat-enriched diet with identical calories and carbohydrate ratio.

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Effect of liquid ubiquinol supplementation on glucose, lipids and antioxidant capacity in type 2 diabetes patients: a double-blind, randomised, placebo-controlled trial

British Journal Of Nutrition ◽

10.1017/s0007114518001241 ◽

2018 ◽

Vol 120 (1) ◽

pp. 57-63 ◽

Cited By ~ 13

Author(s):

Chi-Hua Yen ◽

Ying-Ju Chu ◽

Bor-Jen Lee ◽

Yi-Chin Lin ◽

Ping-Ting Lin

Keyword(s):

Type 2 Diabetes ◽

Placebo Group ◽

Antioxidant Capacity ◽

Coenzyme Q10 ◽

Controlled Trial ◽

Hdl Cholesterol ◽

Lipid Profiles ◽

Double Blind ◽

Diabetes Patients

AbstractUbiquinone is a lipid antioxidant, and a novel liquid ubiquinol (a hydro-soluble, reduced form of coenzyme Q10) supplement was recently developed. The purpose of this study was to examine the levels of glucose, lipids and antioxidant capacity of type 2 diabetes patients after liquid ubiquinol supplementation. This study was designed as a randomised, double-blind, placebo-controlled trial. In all, fifty participants were randomly assigned to a placebo (n 25) or liquid ubiquinol (100 mg/d, n 25) group, and the intervention lasted for 12 weeks. Plasma coenzyme Q10, glucose homoeostasis parameters, lipid profiles, oxidative stress and antioxidative enzyme activities were measured during the study. After 12 weeks of supplementation, glyco Hb (HbA1c) value was significantly decreased in the liquid ubiquinol group (P=0·03), and subjects in the liquid ubiquinol group had significantly lower anti-glycaemic medication effect scores (MES) compared with those in the placebo group (P=0·03). The catalase (P<0·01) and glutathione peroxidase (P=0·03) activities were increased significantly after supplementation. Plasma coenzyme Q10 was correlated with the insulin level (P=0·05), homoeostatic model assessment-insulin resistance (P=0·07), quantitative insulin sensitivity check index (P=0·03) and the anti-hyperglycaemic agents’ MES (P=0·03) after supplementation. Lipid profiles did not change after supplementation; however, the subjects in the placebo group had a significantly lower level of HDL-cholesterol after 12 weeks of intervention. In conclusion, oral intake of 100 mg/d liquid ubiquinol might benefit type 2 diabetes patients by increasing antioxidant enzyme activity levels, reducing HbA1c levels and maintaining HDL-cholesterol levels.

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