Diabetic nephropathy as the cause of end-stage kidney disease reported on the medical evidence form CMS2728 at a single center

Abstract Background Disaster-related stress can increase blood pressure and the incidence of cardiovascular diseases. However, the role of massive disasters in the development of end-stage kidney disease (ESKD) remains unknown. We investigated the incidence and different causes of dialysis initiation in patients with chronic kidney disease in a city affected by the Great East Japan Earthquake. Methods This was a single-center, retrospective observational study. All patients who initiated or were treated with dialysis at Kesennuma City Hospital between 2007 and 2020 were enrolled. The year of dialysis initiation was retrospectively determined based on the initiation date. The causative renal diseases that led to the need for dialysis initiation were divided into four groups: diabetic nephropathy, hypertensive renal disease, glomerulonephritis, and others. Results Age at dialysis initiation differed significantly among the four groups (p = 0.0262). There was a significant difference in the numbers of the four groups before and after the Great East Japan Earthquake (p = 0.0193). The age of hypertensive renal disease patients was significantly higher than those of patients with diabetic nephropathy (p = 0.0070) and glomerulonephritis (p = 0.0386) after the disaster. The increasing number of dialysis initiations after the Great East Japan Earthquake appeared to be associated with changes in hypertensive renal diseases; the number peaked after 10 years. Conclusions There was an increase in the number of dialysis initiations, especially caused by hypertensive renal diseases, for up to 10 years after the Great East Japan Earthquake. Graphic abstract

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Renal histology in diabetic nephropathy predicts progression to end-stage kidney disease but not the rate of renal function decline

BMC Nephrology ◽

10.1186/s12882-020-01943-1 ◽

2020 ◽

Vol 21 (1) ◽

Author(s):

Paraish S. Misra ◽

Stephen G. Szeto ◽

Adriana Krizova ◽

Richard E. Gilbert ◽

Darren A. Yuen

Keyword(s):

Renal Function ◽

Diabetic Nephropathy ◽

Kidney Disease ◽

End Stage Kidney Disease ◽

Renal Function Decline ◽

Renal Histology ◽

End Stage

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SP316THE HIGHER MORTALITY IS ASSOCIATED WITH HEART VALVE DISEASE IN END STAGE KIDNEY DISEASE; A SINGLE CENTER EXPERIENCE

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfy104.sp316 ◽

2018 ◽

Vol 33 (suppl_1) ◽

pp. i450-i451

Author(s):

Ruya Ozelsancak ◽

Nihan Tekkarismaz ◽

Dilek Torun ◽

Hasan Micozkadioglu

Keyword(s):

Kidney Disease ◽

Heart Valve ◽

Valve Disease ◽

Heart Valve Disease ◽

Single Center ◽

End Stage Kidney Disease ◽

Single Center Experience ◽

End Stage

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Microscopic hematuria is a risk factor for end-stage kidney disease in patients with biopsy-proven diabetic nephropathy

BMJ Open Diabetes Research & Care ◽

10.1136/bmjdrc-2020-001863 ◽

2020 ◽

Vol 8 (2) ◽

pp. e001863

Author(s):

Sadanori Okada ◽

Ken-ichi Samejima ◽

Masaru Matsui ◽

Katsuhiko Morimoto ◽

Riri Furuyama ◽

...

Keyword(s):

Blood Pressure ◽

Risk Factor ◽

Diabetic Nephropathy ◽

Kidney Disease ◽

Renal Biopsy ◽

Renal Pathology ◽

Microscopic Hematuria ◽

Vascular Lesions ◽

End Stage Kidney Disease ◽

End Stage

IntroductionThere are fewer reports about whether the presence of hematuria affects the progression of chronic kidney disease in patients with diabetic nephropathy. We analyzed whether microscopic hematuria in diabetic nephropathy is a risk factor for end-stage kidney disease (ESKD).Research design and methodsThe present study was a retrospective cohort study of patients with biopsy-proven diabetic nephropathy. We recruited 397 patients with diabetic nephropathy, which was confirmed by renal biopsy between June 1981 and December 2014 and followed them until October 2018 or death. Patients with microscopic hematuria before renal biopsy were defined as the hematuria group (n=91), and the remainder as the no-hematuria group (n=306). The main outcome was the occurrence of ESKD, which was defined by the requirement of permanent renal replacement therapies.ResultsThe systolic and diastolic blood pressure, serum creatinine and proteinuria were significantly higher, and the estimated glomerular filtration rate was significantly lower in the hematuria group compared with the no-hematuria group. Pathological evaluations revealed that glomerular, tubulointerstitial and vascular lesions in the hematuria group were significantly more severe. During a median of 10.1 years, 44 and 52 patients developed ESKD in the hematuria group and the no-hematuria group, respectively. Survival analyses showed that the incidence of ESKD was significantly higher in the hematuria group compared with the no-hematuria group (log-rank, p<0.0001). The multivariable Cox proportional hazards models revealed a significant association between hematuria and the incidence of ESKD after adjusting for clinically relevant factors, including proteinuria and renal pathology (adjusted HR 1.64, 95% CI 1.03 to 2.60). The subgroups of men, proteinuria ≥0.5 g/day, and systolic blood pressure ≥132 mm Hg showed a stronger association between hematuria and ESKD than their opposing subgroups.ConclusionsMicroscopic hematuria is a risk factor for ESKD in diabetic nephropathy, independent of proteinuria and renal pathology.

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Glycopatterns of Urinary Protein as New Potential Diagnosis Indicators for Diabetic Nephropathy

Journal of Diabetes Research ◽

10.1155/2017/5728087 ◽

2017 ◽

Vol 2017 ◽

pp. 1-14 ◽

Cited By ~ 7

Author(s):

Hanyu Zhu ◽

Moyan Liu ◽

Hanjie Yu ◽

Xiawei Liu ◽

Yaogang Zhong ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Diabetic Nephropathy ◽

Kidney Disease ◽

Protein Microarray ◽

Urinary Protein ◽

Urinary Proteins ◽

End Stage Kidney Disease ◽

Nondiabetic Nephropathy ◽

End Stage ◽

Urine Specimens

Diabetic nephropathy is a major cause of chronic kidney disease and end-stage kidney disease. However, so little is known about alterations of the glycopatterns in urine with the development of diabetic nephropathy. Presently, we interrogated glycopatterns in urine specimens using a lectin microarray. The results showed that expression levels of Siaα2-6Gal/GalNAc recognized by SNA exhibited significantly increased tendency with the development of diabetic nephropathy; moreover, SNA blotting indicated glycoproteins (90 kDa, 70 kDa, and 40 kDa) in urine may contribute to this alteration. Furthermore, the glycopatterns of(GlcNAc)2–4recognized by STL exhibited difference between diabetic and nondiabetic nephropathy. The results of urinary protein microarray fabricated by another 48 urine specimens also indicated(GlcNAc)2–4is a potential indictor to differentiate the patients with diabetic nephropathy from nondiabetic nephropathy. Furtherly, STL blotting showed that the 50 kDa glycoproteins were correlated with this alteration. In conclusion, our data provide pivotal information to monitor the development of diabetic nephropathy and distinguish between diabetic nephropathy and nondiabetic renal disease based on precise alterations of glycopatterns in urinary proteins, but further studies are needed in this regard.

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Vasodilator use in precapillary pulmonary hypertension with end stage kidney disease: A single center experience

Respiratory Medicine ◽

10.1016/j.rmed.2021.106596 ◽

2021 ◽

Vol 188 ◽

pp. 106596

Author(s):

Carlo Arevalo ◽

R. James White ◽

Thu Le ◽

Daniel Lachant

Keyword(s):

Pulmonary Hypertension ◽

Kidney Disease ◽

Single Center ◽

End Stage Kidney Disease ◽

Single Center Experience ◽

End Stage

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Simultaneous membranous nephropathy and diabetic nephropathy occurrence in a patient: A case report

Diabetic Nephropathy ◽

10.2478/dine-2021-0009 ◽

2021 ◽

Vol 1 (1) ◽

pp. 51-54

Author(s):

Binyao Tian ◽

Nan Liu ◽

Tianhua Xu ◽

Xiaodan Liu ◽

Li Yao

Keyword(s):

Diabetes Mellitus ◽

Differential Diagnosis ◽

Diabetic Nephropathy ◽

Kidney Disease ◽

Membranous Nephropathy ◽

Diabetic Kidney Disease ◽

Diabetic Patients ◽

End Stage Kidney Disease ◽

Patients With Diabetes ◽

End Stage

Abstract Membranous nephropathy (MN) is the most common glomerular disease in adults and is constantly associated with the occurrence of nephrotic syndrome. While diabetic kidney disease (DKD) and diabetic nephropathy (DN), which often occur in diabetic patients, are considered as the major causes of end-stage kidney disease. Actually, MN often occurs in patients with diabetes mellitus (DM), but to obtain a clear differential diagnosis without a renal biopsy has become difficult. Here we report the case of a female diabetic patient who developed both MN and DN simultaneously.

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