Multivariate Analysis of Serum Protein Assays in Chronic Hepatitis and Postnecrotic Cirrhosis

1974 ◽  
Vol 20 (4) ◽  
pp. 428-429 ◽  
Author(s):  
Angelo Agostoni ◽  
Bianca Marasini ◽  
Roberto Stabilini ◽  
Ersilio Del Ninno ◽  
Mirella Pontello
Keyword(s):  
Multivariate Analysis ◽  
Chronic Hepatitis ◽  
Serum Protein ◽  
Chronic Persistent Hepatitis ◽  
Good Discrimination ◽  
Chronic Aggressive Hepatitis ◽  
Postnecrotic Cirrhosis ◽  
Protein Assays

Abstract Pre-albumin, albumin, orosomucoid, α-antitrypsin, α-macroglobulin, β1A-globulin, IgG, IgA, and IgM were assayed in the serum of patients with chronic persistent hepatitis, chronic aggressive hepatitis, and postnecrotic cirrhosis. When results were evaluated by multivariate analysis, a good discrimination was obtained, especially between chronic aggressive hepatitis and postnecrotic cirrhosis.

Diagnostic Effectiveness of Electrophoresis and Specific Protein Assays, Evaluated by Discriminate Analysis

1972 ◽  
Vol 18 (2) ◽  
pp. 116-123 ◽  
Author(s):  
Mario Werner ◽  
Samuel H Brooks ◽  
Georg Cohnen
Keyword(s):  
Multivariate Analysis ◽  
Clinical Diagnosis ◽  
Serum Protein ◽  
Protein Pattern ◽  
Paper Electrophoresis ◽  
Specific Protein ◽  
Discriminate Analysis ◽  
Disease Discrimination ◽  
Protein Assays

Abstract With use of the serum protein pattern as a model, we compared the "Diagnostic Effectiveness" of tests of different chemical specificity—i.e., the percentage classified correctly according to the clinical diagnosis. When results obtained from a selected population of subjects with selected diseases were evaluated by multivariate analysis, disease discrimination by paper electrophoresis, which resolves only chemically heterogeneous fractions, was similar to that of a battery of specific assays for individual proteins.

scholarly journals Hepatoprotective Action of Phytopreparation from Limonium gmelinii

2017 ◽  
Vol 4 (1) ◽  
pp. 67
Author(s):  
G.E. Zhusupova ◽  
T.M. Shalakhmetova ◽  
Sh.N. Askarova
Keyword(s):  
Chronic Hepatitis ◽  
Carbon Tetrachloride ◽  
Inflammatory Cell ◽  
Simultaneous Administration ◽  
Hepatic Parenchyma ◽  
Hepatic Lobule ◽  
Cadmium Sulfate ◽  
Chronic Intoxication ◽  
Postnecrotic Cirrhosis ◽  
Limonium Gmelinii

<em></em>Effects of phytopreparation from a plant of <em>Limonium gmelinii</em> were studied on livers of white breedless rats at chronic impact of cadmium sulfate and carbon tetrachloride. It was established the administration of cadmium sulfate during six months caused chronic hepatitis, while the simultaneous administration of preparation from <em>Limonium gmelinii</em> and cadmium sulfate did not result of destructive changes in a liver. Chronic intoxication of the animals by carbon tetrachloride during six months caused progressive postnecrotic cirrhosis. The simultaneous administration of phytopreparation and carbon tetrachloride caused postnecrotic fibrosis in the central part of hepatic lobule only. Not only dystrophic and necrobiotic processes also numerous inflammatory cell infiltrates were observed in hepatic parenchyma of animals which were treated by cadmium sulfate and carbon tetrachloride, while it was not observed at animals which were medicated with phytopreparation. Thus, on the basis of the data was concluded about hepatoprotective action of phytopreparation from<em> Limonium gmelinii</em>.

Serum Bile Acid Levels in Children with Chronic Persistent Hepatitis and Chronic Aggressive Hepatitis

Digestion ◽  
1983 ◽  
Vol 27 (2) ◽  
pp. 81-86 ◽  
Author(s):  
Paloma Jara ◽  
Rosa Codoceo ◽  
Angel Hernanz ◽  
Concepción Castaño ◽  
Carmen Diaz ◽  
...  
Keyword(s):  
Bile Acid ◽  
Chronic Persistent Hepatitis ◽  
Serum Bile Acid ◽  
Chronic Aggressive Hepatitis

Seroprevalence of hepatitis E antibodies and risk profile of HEV seropositivity in The Netherlands, 2006–2007

2012 ◽  
Vol 140 (10) ◽  
pp. 1838-1847 ◽  
Author(s):  
L. VERHOEF ◽  
M. KOOPMANS ◽  
E. DUIZER ◽  
J. BAKKER ◽  
J. REIMERINK ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Chronic Hepatitis ◽  
The Netherlands ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Risk Profile ◽  
Older Age ◽  
Industrialized Countries ◽  
Vulnerable People ◽  
Independent Association

SUMMARYHepatitis E virus (HEV) is now considered an endemic pathogen in industrialized countries, leading to acute and sometimes chronic hepatitis, mostly in vulnerable people. The endemic sources are unclear. A survey in The Netherlands in 2006–2007 showed a 1·9% seroprevalence of HEV antibodies measured by ELISA and confirmed by immunoblot in a nationwide sample. Overall, in 134/7072 (1·9%) seropositive individuals, older age (P<0·01), being male (P<0·01), working with patients (P=0·03), working with animals (P=0·07), recent diarrhoeal complaints (P=0·07) and adhering to a religion that considers pigs unclean (P<0·01) were independently associated with seropositivity in multivariate analysis. Sub-analysis of 59/4022 (1·5%) anti-HEV antibody-positive subjects with probable endemic exposure showed independent association with youngest household member being aged <5 years or between 19 and <65 years (P=0·05) in multivariate analysis. These findings may contribute to a better understanding of the sources of endemic HEV exposure, and also highlight the need for systematic epidemiological and serological evaluation of new cases.

Multivariate analysis of prognostic factors in chronic hepatitis type B

1989 ◽  
Vol 9 ◽  
pp. S148
Author(s):  
G. Fattovich ◽  
L. Brollo ◽  
F. Noventa ◽  
P. Pontisso ◽  
G. Giustina ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Chronic Hepatitis ◽  
Prognostic Factors ◽  
Type B ◽  
Chronic Hepatitis Type ◽  
Hepatitis Type B

Manganese, Copper, and Zinc Concentrations in Serum and Packed Blood Cells during Acute Hepatitis, Chronic Hepatitis, and Posthepatitic Cirrhosis

1974 ◽  
Vol 20 (9) ◽  
pp. 1141-1145 ◽  
Author(s):  
Jacques Versieck ◽  
Fabrice Barbier ◽  
Albert Speecke ◽  
Julien Hoste
Keyword(s):  
Chronic Hepatitis ◽  
Acute Hepatitis ◽  
Blood Cells ◽  
Serum Zinc ◽  
Manganese Concentration ◽  
Copper And Zinc ◽  
Postnecrotic Cirrhosis ◽  
Zinc Concentrations ◽  
The Mean ◽  
Manganese Copper

Abstract Manganese, copper, and zinc concentrations were determined in serum and packed blood cells of normal controls, patients with acute and chronic (persistent or aggressive) hepatitis, and cases of postnecrotic cirrhosis. During the active phase of acute hepatitis, serum manganese concentrations are invariably increased; the difference between the mean value and the normal is highly significant, P &lt; 0.001. The mean serum copper is also significantly increased (P &lt; 0.01). The concentrations become normal during the subsiding phase. In chronic aggressive hepatitis and posthepatitic cirrhosis, the mean serum manganese concentration is increased, P &lt; 0.001, whereas the serum zinc concentration is frequently decreased. There is a highly significant (P &lt; 0.001) positive correlation between serum manganese concentration and the activity in serum of aminotransferases, in subjects with acute or chronic hepatitis or postnecrotic cirrhosis.

Serum protein variations in the course of chronic hepatitis

2009 ◽  
Vol 130 (S206) ◽  
pp. 392-398
Author(s):  
Mogens Bjørneboe
Keyword(s):  
Chronic Hepatitis ◽  
Serum Protein

Standards for Total Serum Protein Assays— A Collaborative Study

1975 ◽  
Vol 21 (8) ◽  
pp. 1159-1166 ◽  
Author(s):  
Basil T Doumas
Keyword(s):  
Human Serum Albumin ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Serum Protein ◽  
Bovine Serum ◽  
Total Serum Protein ◽  
Total Serum ◽  
Final Reaction ◽  
Protein Assays

Abstract We have studied the standardization of total serum protein assay with the biuret reaction. Standard solutions were prepared from lyophilized preparations of human serum albumin and bovine serum albumin, with corrections made for volatile material and ash contents. These solutions and a solution of crystalline albumin standard were analyzed with a new stable biuret reagent, to establish absorptivity values (values for the absorbance of a 1 g/liter final reaction mixture). The mean values obtained were 0.302, 0.292, and 0.290 for human serum albumin, bovine serum albumin, and the crystalline albumin, respectively. We believe that the established absorptivity value will improve the accuracy of serum protein determinations. We studied the linearity of the relation between color produced and protein concentration, with use of the solutions described above and a serum pool. The color adheres to Beer's law up to the highest concentration tested: 3 g/liter for HSA and BSA, and 2.8 g/liter for serum in the final reaction mixture. The new biuret reagent has been stable for one year at room temperature. We recommend the use of bovine serum albumin as a primary standard for serum protein assays. It is inexpensive, easily available, and exhibits the best linearity in the biuret reaction.

Factors predictive of liver cirrhosis in patients with chronic hepatitis B: a multivariate analysis in a longitudinal study

2000 ◽  
Vol 12 (6) ◽  
pp. 687-693 ◽  
Author(s):  
Teh-la Huo ◽  
Jaw-Ching Wu ◽  
Shinn-Jang Hwang ◽  
Chung-Ru Lai ◽  
Pui-Ching Lee ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Liver Cirrhosis ◽  
Chronic Hepatitis ◽  
Longitudinal Study ◽  
Hepatitis B ◽  
Chronic Hepatitis B
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