scholarly journals Hepatoprotective Action of Phytopreparation from Limonium gmelinii

2017 ◽  
Vol 4 (1) ◽  
pp. 67
Author(s):  
G.E. Zhusupova ◽  
T.M. Shalakhmetova ◽  
Sh.N. Askarova

<em></em>Effects of phytopreparation from a plant of <em>Limonium gmelinii</em> were studied on livers of white breedless rats at chronic impact of cadmium sulfate and carbon tetrachloride. It was established the administration of cadmium sulfate during six months caused chronic hepatitis, while the simultaneous administration of preparation from <em>Limonium gmelinii</em> and cadmium sulfate did not result of destructive changes in a liver. Chronic intoxication of the animals by carbon tetrachloride during six months caused progressive postnecrotic cirrhosis. The simultaneous administration of phytopreparation and carbon tetrachloride caused postnecrotic fibrosis in the central part of hepatic lobule only. Not only dystrophic and necrobiotic processes also numerous inflammatory cell infiltrates were observed in hepatic parenchyma of animals which were treated by cadmium sulfate and carbon tetrachloride, while it was not observed at animals which were medicated with phytopreparation. Thus, on the basis of the data was concluded about hepatoprotective action of phytopreparation from<em> Limonium gmelinii</em>.

2004 ◽  
Vol 3 (2) ◽  
pp. 79-85
Author(s):  
B. I. Alperovich ◽  
A. V. Orlov ◽  
Yu. V. Kiselyova

The aim of investigation was to evaluate the liver cryodestruction effect on the course of chronic hepatitis and hepatocirrhosis. Experimental part of the investigation has been fulfilled on 220 white mongrel rats with toxic hepatocirrhosis caused by carbon tetrachloride. Evaluation of hepatic parenchyma state has been done by the following criteria: factor of parenchyma normalization and factor of sclerotization. The comparison of these factors in the basic and control groups has revealed an evident positive dynamics in normalization of histological hepatic structure.


1974 ◽  
Vol 20 (9) ◽  
pp. 1141-1145 ◽  
Author(s):  
Jacques Versieck ◽  
Fabrice Barbier ◽  
Albert Speecke ◽  
Julien Hoste

Abstract Manganese, copper, and zinc concentrations were determined in serum and packed blood cells of normal controls, patients with acute and chronic (persistent or aggressive) hepatitis, and cases of postnecrotic cirrhosis. During the active phase of acute hepatitis, serum manganese concentrations are invariably increased; the difference between the mean value and the normal is highly significant, P &lt; 0.001. The mean serum copper is also significantly increased (P &lt; 0.01). The concentrations become normal during the subsiding phase. In chronic aggressive hepatitis and posthepatitic cirrhosis, the mean serum manganese concentration is increased, P &lt; 0.001, whereas the serum zinc concentration is frequently decreased. There is a highly significant (P &lt; 0.001) positive correlation between serum manganese concentration and the activity in serum of aminotransferases, in subjects with acute or chronic hepatitis or postnecrotic cirrhosis.


2005 ◽  
Vol 62 (7-8) ◽  
pp. 591-594 ◽  
Author(s):  
Darko Nozic ◽  
Jovan Dimitrijevic ◽  
Slavica Knezevic-Usaj

Background. Autoimmune hepatitis is a chronic inflammatory disease of the liver of unknown etiology, characterized by the loss of tolerance against hepatic tissue, leading to the destruction of hepatic parenchyma. It predominantly affects females, and rarely occurs in the same family. Case report. In this paper we presented brother and sister with autoimmune hepatitis according to the criteria of the International Autoimmune Hepatitis Group. Conclusion. Because of a possible genetic predisposition to autoimmune hepatitis, the occurrence of the disease in a family member suggested the need to examine other family members.


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