Relation between lipoprotein(a) concentrations in patients with acute-phase response and risk analysis for coronary heart disease

Abstract This study investigated whether lipoprotein(a) [Lp(a)] is an acute-phase reactant that can cause important bias in risk factor analysis for coronary heart disease among patients with an acute-phase response (APR patients). To determine whether serum Lp(a) concentrations increase among APR patients, we compared the Lp(a) concentrations and apolipoprotein(a) [apo(a)] phenotypes of 100 controls with those of a random sampling of 100 APR patients. Serum Lp(a) concentration was measured by ELISA; Lp(a) phenotyping was performed by electrophoresis on sodium dodecyl sulfate–polyacrylamide gel. Lp(a) was significantly (P <0.0001) higher among APR patients (mean ± SD 0.300 ± 0.284 g/L) than among controls (0.118 ± 0.193 g/L) even though the distribution of apo(a) phenotypes did not differ significantly. The 100 APR patients were grouped into 4 categories: 48 patients with infections, 25 postoperative patients, 17 patients with tumors, and 10 patients with other diseases, all of whom showed substantially higher Lp(a) values than did the controls. For the S5, S4S5, S5S5, and S4 phenotypes, the mean concentrations of serum Lp(a) were substantially higher among the APR patients.

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Modification of serum apolipoprotein A-I, apolipoprotein B and lipoprotein(a) levels after bisphosphonates-induced acute phase response

Clinica Chimica Acta ◽

10.1016/s0009-8981(97)00212-x ◽

1998 ◽

Vol 271 (1) ◽

pp. 79-87 ◽

Cited By ~ 31

Author(s):

Giuseppe Lippi ◽

Vania Braga ◽

Silvano Adami ◽

Giancesare Guidi

Keyword(s):

Acute Phase ◽

Apolipoprotein B ◽

Acute Phase Response ◽

Phase Response ◽

Lipoprotein A ◽

Apolipoprotein A

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Serum lipids, lipoprotein(a) level, and apolipoprotein(a) isoforms as prognostic markers in patients with coronary heart disease

Journal of Internal Medicine ◽

10.1046/j.1365-2796.2002.00937.x ◽

2002 ◽

Vol 251 (2) ◽

pp. 111-118 ◽

Cited By ~ 23

Author(s):

U. Lundstam ◽

J. Herlitz ◽

T. Karlsson ◽

T. Linden ◽

O. Wiklund

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Serum Lipids ◽

Prognostic Markers ◽

Lipoprotein A ◽

Apolipoprotein A

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Effect of ageing on plasma lipoprotein(a) levels

Annals of Clinical Biochemistry International Journal of Laboratory Medicine ◽

10.1258/0004563021901937 ◽

2002 ◽

Vol 39 (3) ◽

pp. 237-240 ◽

Cited By ~ 11

Author(s):

Harukuni Akita ◽

Miyao Matsubara ◽

Hitoshi Shibuya ◽

Hirotoshi Fuda ◽

Hitoshi Chiba

Keyword(s):

Molecular Weight ◽

Coronary Heart Disease ◽

Risk Factor ◽

Heart Disease ◽

The Elderly ◽

Low Molecular Weight ◽

Lipoprotein A ◽

Significant Difference ◽

The Mean ◽

Japanese Subjects

Background Lipoprotein(a) [Lp(a)] is a risk factor for atherosclerosis and increases with age. The purpose of this study was to determine the effect of ageing on Lp(a) for three different apo(a) phenotypes. Methods We measured plasma Lp(a) concentrations in 551 unrelated Japanese subjects (20-88 years of age). We performed statistical analyses separately for three apo(a) phenotypes: the low-molecular-weight (LMW) phenotype with the F, B or S1 isoform, the intermediate-molecular-weight (IMW) phenotype with the S2 isoform and the high-molecular-weight (HMW) phenotype with the S3 or S4 isoform. Results For each phenotype, the mean plasma Lp(a) concentration and the frequency of Lp(a) concentrations ≥ 250 mg/L increased with age. Further, a statistically significant difference was always found between the younger subjects (20-39 years of age) and the elderly (over 60 years). The frequency of coronary heart disease increased with age, particularly for the LMW and IMW phenotypes. Conclusions We conclude that ageing elevates plasma Lp(a) concentrations, which may have a role in the prevalence of coronary heart disease in the elderly, especially those with the LMW or IMW phenotypes.

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