PS02.101: PREOPERATIVE TREATMENT BASED ON THE DCF CHEMOTHERAPY AND SUPPORTIVE THERAPY FOR ESOPHAGEAL CANCER

Abstract Background The neoadjuvant chemotherapy using CDDP and 5-FU(CF) is the standard treatment for advanced esophageal cancer, defined as clinical stage II/III in Japan. However, more powerful chemotherapy has been required for the treatment of cases of cStageIII cases. In 2011, the combination treatment of CF and Docetaxel (DCF) was introduced for the treatment of those cases in our institute. DCF therapy increased chemotherapy remarkable cases. But, adverse events occur at high rates, including high myelosuppression. Therefore, it is necessary to ensure support by early intervention of supportive therapy so as not to exacerbate adverse events. We report about treatment outcome in preoperative DCF therapy cases. Methods We treated 128 esophageal cancer patients who underwent surgery following preoperative DCF therapy between 2011 and July 2017, and preoperative DCF was administered to 128 patients 2 course completely. The neoadjuvant chemotherapy regimen using DCF is Docetaxel:70mg/m2 (day1) + CDDP:70mg/m2 (day1) + 5-FU:700mg/m2 (day1–5). Results In the preoperative DCF group, overall response rate (over PR) was 51.5%. There were 37 cases in 128 cases of pathological tissue effect judgment for Grade 2 and 3. 14 cases of them (14cases/37cases:37.8%) had lymph node metastasis. Therefore it is necessary to control lymph node metastasis by surgery even in a remarkable group. Almost all patients experienced grade 4 adverse events, particularly neutropenia is a high frequency. From the start of chemotherapy, pretreatment of intraoral infection lesion and prevention and treatment of oral mucositis are performed. Considering the degree of myelosuppression during initial chemotherapy, in the second course, we actively administer G-CSF preparation. Conclusion A good prognosis can be expected if preoperative DCF therapy is effective. It is necessary to perform intensive and safe preoperative chemotherapy with appropriate supportive therapy intervention. Disclosure All authors have declared no conflicts of interest.

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PS02.067: PREDICTIVE VALUE OF 18F-FDG PET-CT METABOLIC PARAMETERS PRIOR TO TREATMENT ON SHORT-TERM CURATIVE EFFECTS OF ESOPHAGEAL CANCER

Diseases of the Esophagus ◽

10.1093/dote/doy089.ps02.067 ◽

2018 ◽

Vol 31 (Supplement_1) ◽

pp. 139-139

Author(s):

Jiancheng Li ◽

Weijie Sun

Keyword(s):

Esophageal Cancer ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Clinical Stage ◽

Cancer Site ◽

Lesion Length ◽

Depth Of Invasion ◽

Short Term ◽

Node Metastasis ◽

Pet Ct

Abstract Background To investigate predictive value of pre-treatment maximal standardized uptake value (SUVmax) and metabolic tumor volume (MTV) on short-term curative effects in esophageal cancer patients. Methods Retrospective analysis was made for 98 cases of patients with esophageal cancer treated by radiotherapy or radiotherapy combined with chemotherapy in Fujian Cancer Hospital. Before treatment, 18F-FDG PET-CT scan was performed. PET/CT images prior to treatment were read by two doctors with a high-level professional title using double-blind method. SUVmax and MTV were determined and averaged. 1–3 months after treatment, an experienced deputy director of PET/CT center and a radiotherapist evaluated the curative effect of all patients according to the Response Evaluation Criteria in Solid Tumor (RECIST). Results There were no significant differences of SUVmax and MTV between two groups in age, gender, cancer site, and differential extent (P > 0.05). Factors related to SUVmax were lesion length, depth of invasion, lymph node metastasis and clinical stage, while differences were statistically significant (P < 0.05). SUVmax & MTV were positively correlated with lesion length, depth of invasion, lymph node metastasis and clinical stage. The effective rate was 67.3% (66/98). SUVmax (r = -0.283, P = 0.049) and MTV(r = -0.379, P = 0.007) were negatively correlated with short-term curative effects, but the curative effect of MTV was higher than that of SUVmax. Conclusion There were no significant effects of clinical factors e.g. age, gender, esophageal cancer site, and differential extent on SUVmax and MTV, but length of lesion, depth of invasion, lymph node metastasis and clinical stage had significant effect on SUVmax and MTV. SUVmax and MTV prior to treatment can predict short-term curative effects of radiotherapy or radiotherapy combined with chemotherapy for esophageal cancer patients, but MTV is more predictive than SUVmax. Disclosure All authors have declared no conflicts of interest.

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PS02.131: PATTERN OF LYMPHATIC METASTASIS OF CERVICAL ESOPHAGEAL CANCER

Diseases of the Esophagus ◽

10.1093/dote/doy089.ps02.131 ◽

2018 ◽

Vol 31 (Supplement_1) ◽

pp. 158-158

Author(s):

Jiancheng Li ◽

Xiuling Shi

Keyword(s):

Esophageal Cancer ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Lymph Nodes ◽

Conflicts Of Interest ◽

Mediastinal Lymph Node ◽

Radical Resection ◽

Cervical Esophageal Cancer ◽

Cervical Lymph Nodes ◽

Node Metastasis

Abstract Background Cervical esophageal cancer were rarely surgeryed Analysis and discussion of lymph node metastasis of cervical esophageal cancer Methods From July 2008 to June 2017, 10 cases of successful esophagectomy of cervical esophageal cance in our hospital underwent radical resection. Surgical dissection range was the neck and the upper mediastinum. A total of 231 lymph nodes were dissected. The lymph nodes were summarized and grouped in different ways, and analyzed the law of lymph node metastasis. Results 7 cases of esophageal cancer, lymph node metastasis occurred, and the rate of lymph node metastasis was 70% (7/10), of which 1 case was T1b stage. 17 lymph node metastases, the degree of lymph node metastasis was 7.36% (17/231), including 4 esophageal lymph nodes, 12 cervical lymph nodes and 1 upper right mediastinal lymph node. Conclusion Cervical esophageal cancer lymph node metastasis can spread occur early metastasis, and the metastasis site were mainly in neck.. Disclosure All authors have declared no conflicts of interest.

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